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排序方式: 共有1312条查询结果,搜索用时 109 毫秒
101.
Aleksandar Rakovic MSc Barbara Stiller MSc Ana Djarmati PhD Antonia Flaquer MSc Jan Freudenberg MD Mohammad‐Reza Toliat PhD Michael Linnebank MD Vladimir Kostic MD Katja Lohmann PhD Sebastian Paus MD Peter Nürnberg PhD Christian Kubisch MD Christine Klein MD Ullrich Wüllner MD Alfredo Ramirez MD 《Movement disorders》2009,24(3):429-433
A role of ATP13A2 in early‐onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late‐onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case–control association study in this age‐of‐onset group with PD. The initial sample was of German origin and consisted of 220 patients with late‐onset PD (mean age of onset 60.1 years) and 232 age‐matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (PUNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late‐onset PD (mean age of onset 51.7 years) and 150 age‐ and ethnic‐matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late‐onset PD. © 2008 Movement Disorder Society 相似文献
102.
Damir Kosutic Vedran Uglesic Predrag Knezevic Aleksandar Milenovic Miso Virag 《Journal of plastic, reconstructive & aesthetic surgery》2008,61(6):620-627
A total of 21 patients with latissimus dorsi-scapula free flap reconstruction immediately following radical maxillectomy together with orbital exenteration are presented. Orbital exenteration was performed in all patients due to tumour invasion at the time of diagnosis. There was no total flap failure. Two tissue components subdivided into separate flap units with individual vascular pedicles linked by a single vascular source provide an ideal reconstructive solution for massive defects of the mid-face and orbit. Separate arcs of rotation of each flap unit permit greater mobility necessary for complex three-dimensional reconstruction. A vertically positioned angle of the scapula enables simultaneous reconstruction of the malar eminence and alveolar ridge whereas spontaneous intraoral epithelialisation of the latissimus dorsi muscle requires no additional procedure. For these reasons, in our opinion, combined latissimus dorsi-scapula free flap should be considered the first choice in reconstruction of defects following total maxillectomy with orbital exenteration. 相似文献
103.
Nenad Ivančević Dejan Radenković Vesna Bumbaširević Aleksandar Karamarković Vasilije Jeremić Nevena Kalezić Tatjana Vodnik Biljana Beleslin Nataša Milić Pavle Gregorić Miloš Žarković 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2008,393(3):397-403
Background and aims The present study attempted to identify the diagnostic significance of procalcitonin (PCT) in acute abdominal conditions as
well as the range of concentrations relating to diagnosis of abdominal sepsis.
Materials and methods This was prospective clinical study. The study included 98 consecutive patients with acute abdominal conditions, divided in
sepsis and systemic inflammatory response syndrome (SIRS) group.
Results PCT concentrations on admission were significantly higher in the sepsis group than in the SIRS group (median [interquartile
range] 2.32 [7.41] vs 0.45 ng/ml [2.62]). A cutoff value of 1.1 ng/ml yielded 72.4% sensitivity and 62.5% specificity. In
a group of patients with abdominal symptoms lasting for more than 24 h, a cut-off value of 1.1 ng/ml yielded higher sensitivity
(82.9%) and higher specificity (77.3%).
Conclusion Our results suggest that PCT measurements may be useful for early, preoperative diagnosis of abdominal sepsis. 相似文献
104.
In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration 总被引:1,自引:0,他引:1
Babic AM Josefsson EC Bergmeier W Wagner DD Kaufman RM Silberstein LE Stossel TP Hartwig JH Hoffmeister KM 《Transfusion》2007,47(3):442-451
BACKGROUND: Short-term refrigeration of platelets (PLTs) in the absence of plasma results in their rapid clearance after transfusion. Blocking beta-N-acetylglucosamine (beta-GlcNAc) residues of glycoprotein Ibalpha (GPIbalpha) with galactose prevents binding of refrigerated human and mouse PLTs to macrophages and prolongs the circulation times of refrigerated mouse PLTs. PLT-associated galactosyltransferase efficiently galactosylates chilled PLTs in the presence of its substrate UDP-galactose is added to PLT-rich plasma. STUDY DESIGN AND METHODS: To characterize the hemostatic function of refrigerated and galactosylated human PLTs processed in the blood bank, PLT aggregation was studied in vitro under static and flow conditions and expression of integrin beta3 (CD61), CD62P (P-selectin), GPIbalpha (CD42b), annexin V binding, and integrin alphaIIbeta3 activation with flow cytometry. Affinity of macrophages for galactosylated refrigerated PLTs was evaluated with THP-1 cells, which recognize and phagocytize refrigerated PLTs. RESULTS: PLTs refrigerated and galactosylated for 14 days 1) maintained their ability to aggregate when exposed to agonists in a standard aggregometry assay, 2) showed less pronounced changes in surface expression of GPIbalpha compared with room temperature (RT)-stored PLTs, 3) increased P-selectin expression, and 4) were poorly phagocytized by differentiated THP-1 cells in vitro. In addition, it is shown that refrigeration of PLTs does not affect their adhesive properties under in vitro flow conditions. CONCLUSION: It is shown that refrigerated human PLTs retain in vitro function better than RT PLTs during storage and demonstrate that galactosylation prevents recognition of stored refrigerated PLTs by macrophages in vitro. 相似文献
105.
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection 总被引:14,自引:0,他引:14
Motsinger A Haas DW Stanic AK Van Kaer L Joyce S Unutmaz D 《The Journal of experimental medicine》2002,195(7):869-879
Human natural killer (NK) T cells are unique T lymphocytes that express an invariant T cell receptor (TCR) Valpha24-Vbeta11 and have been implicated to play a role in various diseases. A subset of NKT cells express CD4 and hence are potential targets for human immunodeficiency virus (HIV)-1 infection. We demonstrate that both resting and activated human Valpha24(+) T cells express high levels of the HIV-1 coreceptors CCR5 and Bonzo (CXCR6), but low levels of CCR7, as compared with conventional T cells. Remarkably NKT cells activated with alpha-galactosylceramide (alpha-GalCer)-pulsed dendritic cells were profoundly more susceptible to infection with R5-tropic, but not X4-tropic, strains of HIV-1, compared with conventional CD4(+) T cells. Furthermore, resting CD4(+) NKT cells were also more susceptible to infection. After initial infection, HIV-1 rapidly replicated and depleted the CD4(+) subset of NKT cells. In addition, peripheral blood NKT cells were markedly and selectively depleted in HIV-1 infected individuals. Although the mechanisms of this decline are not clear, low numbers or absence of NKT cells may affect the course of HIV-1 infection. Taken together, our findings indicate that CD4(+) NKT cells are directly targeted by HIV-1 and may have a potential role during viral transmission and spread in vivo. 相似文献
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110.
Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation 总被引:1,自引:0,他引:1
Harhaji-Trajkovic L Arsikin K Kravic-Stevovic T Petricevic S Tovilovic G Pantovic A Zogovic N Ristic B Janjetovic K Bumbasirevic V Trajkovic V 《Pharmaceutical research》2012,29(8):2249-2263