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41.
Ángela López-Sainz Aitor Hernandez-Hernandez Esther Gonzalez-Lopez Fernando Domínguez Maria Alejandra Restrepo-Cordoba Marta Cobo-Marcos Manuel Gómez-Bueno Francisco Jose Hernandez-Perez Juan Francisco Oteo Jesus G. Mirelis Miguel Angel Cavero Vanessa Moñivas Susana Mingo Santos F. Javier de Haro-del Moral Isabel Krsnik Clara Salas Belén Bornstein Ana Briceño Pablo Garcia-Pavia 《Revista espa?ola de cardiología》2021,74(2):149-158
Introduction and objectivesCardiac amyloidosis (CA) is produced by amyloid fiber deposition in the myocardium. The most frequent forms are those caused by light chains (AL) and transthyretin (ATTR). Our objective was to describe the diagnosis, treatment and outcomes of CA in a specialized Spanish center.MethodsWe included all patients diagnosed with CA in Hospital Universitario Puerta de Hierro Majadahonda from May 2008 to September 2018. We analyzed their clinical characteristics, outcomes, and survival.ResultsWe included 180 patients with CA, of whom 64 (36%) had AL (50% men; mean age, 65 ± 11 years) and 116 had ATTR (72% men; mean age 79 ± 11 years; 18 with hereditary ATTR). The most common presentation was heart failure in both groups (81% in AL and 45% in ATTR, P < .01). Other forms of presentation in ATTR patients were atrial arrhythmias (16%), conduction disorders (6%), and incidental finding (6%); 70 patients (40%), had a previous alternative cardiac diagnosis. Diagnosis was noninvasive in 75% of ATTR patients. Diagnostic delay was higher in ATTR (2.8 ± 4.3 vs 0.6 ± 0.7 years, P < .001), but mortality was greater in AL patients (48% vs 32%, P = .028). Independent predictors of mortality were AL subtype (HR, 6.16; 95%CI, 1.56-24.30; P = .01), female sex (HR, 2.35; 95%CI,1.24-4.46; P = .01), and NYHA functional class III-IV (HR, 2.07; 95%CI, 1.11-3.89; P = .02).ConclusionsCA is a clinical challenge, with wide variability in its presentation depending on the subtype, leading to diagnostic delay and high mortality. Improvements are needed in the early diagnosis and treatment of these patients. 相似文献
42.
Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli
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Beatriz Moreno-Bruna Edurne Baroja-Fernández Francisco José Mu?oz Ainara Bastarrica-Berasategui Aitor Zandueta-Criado Milagros Rodríguez-López I?igo Lasa Takashi Akazawa Javier Pozueta-Romero 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(14):8128-8132
An adenosine diphosphate sugar pyrophosphatase (ASPPase, EC ) has been characterized by using Escherichia coli. This enzyme, whose activities in the cell are inversely correlated with the intracellular glycogen content and the glucose concentration in the culture medium, hydrolyzes ADP-glucose, the precursor molecule of glycogen biosynthesis. ASPPase was purified to apparent homogeneity (over 3,000-fold), and sequence analyses revealed that it is a member of the ubiquitously distributed group of nucleotide pyrophosphatases designated as "nudix" hydrolases. Insertional mutagenesis experiments leading to the inactivation of the ASPPase encoding gene, aspP, produced cells with marginally low enzymatic activities and higher glycogen content than wild-type bacteria. aspP was cloned into an expression vector and introduced into E. coli. Transformed cells were shown to contain a dramatically reduced amount of glycogen, as compared with the untransformed bacteria. No pleiotropic changes in the bacterial growth occurred in both the aspP-overexpressing and aspP-deficient strains. The overall results pinpoint the reaction catalyzed by ASPPase as a potential step of regulating glycogen biosynthesis in E. coli. 相似文献
43.
Sara García-Villanueva Marta Domínguez-Gil González Jorge Gayete Martínez Juan Luis Muñoz Bellido José Santos Salas Valien Celina Echevarria Iturbe Manuel González Sagrado José María Jiménez Pérez Aitor Curiel de Arcaute López Silvia Rojo Rello José María Eiros Bouza Raúl Ortiz de Lejarazu Leonardo 《Enfermedades infecciosas y microbiología clínica》2019,37(5):314-318
44.
Aitor Uribarri Sebastian V. Rojas Jasmin S. Hanke Günes Dogan Thierry Siemeni Tim Kaufeld Fabio Ius Tobias Goecke Sara Rojas-Hernandez Gregor Warnecke Christoph Bara Murat Avsar Axel Haverich 《Revista espa?ola de cardiología》2019,72(8):608-615
Introduction and objectivesMalnutrition has been shown to affect clinical outcomes in patients with heart failure. The aim of this study was to analyze the impact of preoperative nutritional status assessed by the nutritional risk index (NRI) on the prognosis of patients with a continuous-flow left ventricular assist device (cf-LVAD).MethodsWe performed a retrospective study of 279 patients who underwent cf-LVAD implantation between 2009 and 2015 in our center. Preoperative NRI was calculated and the patients were followed-up for 1 year. The association between preoperative NRI and postoperative clinical events was analyzed using multivariable logistic regression.ResultsThe prevalence of severe (NRI < 83.5), moderate (83.5 ≤ NRI < 97.5) and mild (97.5 ≤ NRI < 100) nutritional risk was 5.4%, 21.5%, and 9.3%. Mortality rates 1 year after cf-LVAD implantation in these 3 categories were 53.3%, 31.7%, 23.1% vs 18.0% (P < .001) in patients with a normal IRN. A normal preoperative NRI value was an independent predictor of lower risk of death from any cause during follow-up (aHR per 1 unit, 0.961; 95%CI, 0.941-0.981; P < .001) was and a predictor for a lower risk of postoperative infections (aOR, 0.968; 95%CI, 0.946-0.991; P = .007), respiratory failure (aOR, 0,961; 95%CI, 0.936-0.987; P = .004), and right heart failure (aOR, 0.963; 95%CI, 0.934-0.992; P = .014).ConclusionsMalnourished patients are at increased risk for postoperative complications and death after cf-LVAD implantation. Assessment of nutritional risk could improve patient selection and the early initiation of nutritional support.Full English text available from: www.revespcardiol.org/en 相似文献
45.
Joo-Young LEE Joonhee PARK Huiju PARK Aitor COCA Jung-Hyun KIM Nigel A.S. TAYLOR Su-Young SON Yutaka TOCHIHARA 《Industrial health》2015,53(5):434-444
The purpose of this study was to investigate smart features required for the next
generation of personal protective equipment (PPE) for firefighters in Australia, Korea,
Japan, and the USA. Questionnaire responses were obtained from 167 Australian, 351
Japanese, 413 Korean, and 763 U.S. firefighters (1,611 males and 61 females). Preferences
concerning smart features varied among countries, with 27% of Korean and 30% of U.S.
firefighters identifying ‘a location monitoring system’ as the most important element. On
the other hand, 43% of Japanese firefighters preferred ‘an automatic body cooling system’
while 21% of the Australian firefighters selected equally ‘an automatic body cooling
system’ and ‘a wireless communication system’. When asked to rank these elements in
descending priority, responses across these countries were very similar with the following
items ranked highest: ‘a location monitoring system’, ‘an automatic body cooling system’,
‘a wireless communication system’, and ‘a vision support system’. The least preferred
elements were ‘an automatic body warming system’ and ‘a voice recording system’. No
preferential relationship was apparent for age, work experience, gender or anthropometric
characteristics. These results have implications for the development of the next
generation of PPE along with the international standardisation of the smart PPE. 相似文献
46.
Laorden L Herrera-León S Martínez I Sanchez A Kromidas L Bikandi J Rementeria A Echeita A Garaizar J 《Journal of clinical microbiology》2010,48(12):4563-4566
We analyzed a collection of 60 Salmonella enterica 4,5,12:i:- phage type U302 multidrug-resistant monophasic variant strains, isolated in Spain between 2000 and 2007. Most strains showed resistance to ampicillin (A), chloramphenicol (C), sulfamethoxazole (Su), gentamicin (G), streptomycin (S), tetracycline (T), and co-trimoxazole (SxT) (an ACSuGSTSxT resistance pattern). Only one pulsed-field gel electrophoresis (PFGE) type was detected, with 19 subtypes (Simpson's index of diversity [SID]=0.89). Multiple-locus variable-number tandem-repeat analysis (MLVA) showed more variability, with 32 profiles (SID=0.97), but only showed diversity at the STTR5 and STTR6 loci. PCR and sequencing demonstrated all strains contained the same allantoin-glyoxylate pathway deletion. Four types of deletions were detected in the fljAB operon, all starting at the same position, at the STM2758 gene, and followed by an IS26 insertion. Furthermore, a representative set of strains of the four deletion types harbored plasmids with IS26. We propose that a Salmonella enterica serotype Typhimurium U302 multidrug-resistant (ACSuGSTSxT) strain, defective for the allantoin-glyoxylate pathway and containing IS26 at plasmid pU302L, could be the ancestor of the variant in Spain. 相似文献
47.
Gonzalo Sánchez-Benavides Beatriz Gómez-Ansón Aitor Sainz Yolanda Vives Manuel Delfino Jordi Peña-Casanova 《Psychiatry Research: Neuroimaging》2010,181(3):219-225
Hippocampal volume is reduced in Alzheimer Disease (AD) and has been proposed as a possible surrogate biomarker to aid early diagnosis. Whilst automated methods to segment the hippocampus from magnetic resonance images are available, manual segmentation, in spite of being time-consuming and unsuitable for large samples, is still the standard. In order to study the validity of FreeSurfer's automated method, we compared hippocampal automated measures with manual tracing in a sample composed of healthy elderly (N = 41), Mild Cognitive Impairment (MCI) (N = 23), and AD (N = 25) subjects. Percent volume overlap, percent volume difference, correlations, and Bland–Altman plots were studied. Automated measures were slightly larger than hand tracing ones (mean difference 10%). Percent volume overlap showed good results, but was far from perfect (78%). Manual and automated volume correlations were approximately 0.84 and the Bland–Altman analysis showed acceptable interchangeability of methods. Within-group analysis demonstrated that patient samples obtained smaller values in validity indexes than controls. Globally, FreeSurfer's automated hippocampal volumetry showed adequate validity when compared to manual tracing, with a tendency to overestimation. Nevertheless, the greater difference between automated and manual segmentation in atrophic brains suggests that studies in AD based on this software could be more likely to produce false negatives. 相似文献
48.
Francisco Santaolalla Cosme Ere?o Agustin Martínez Ana Sánchez del Rey Aitor Zabala 《Breast care (Basel, Switzerland)》2009,4(3):192-194
Summary
Background
Metastatic tumors account for less than 1% of all malignant tumors occurring in the oral cavity.Case Report
The clinical case of a 94-year-old patient with a mandibular tumor is reported here. The patient had undergone bilateral mastectomy more than 25 years before. An immunohistochemical study found hormone receptors in signet ring cells, suggesting a diagnosis of breast cancer metastasis.Conclusion
Immunohistochemical diagnosis and antineoplastic hormone therapy is the cornerstone in the management of this clinical case.Key Words: Mandible, Metastasis, Breast cancer, Signet ring cells 相似文献49.
50.