全文获取类型
收费全文 | 2704篇 |
免费 | 127篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 109篇 |
妇产科学 | 60篇 |
基础医学 | 251篇 |
口腔科学 | 50篇 |
临床医学 | 168篇 |
内科学 | 540篇 |
皮肤病学 | 191篇 |
神经病学 | 134篇 |
特种医学 | 63篇 |
外科学 | 601篇 |
综合类 | 62篇 |
一般理论 | 1篇 |
预防医学 | 73篇 |
眼科学 | 123篇 |
药学 | 218篇 |
中国医学 | 2篇 |
肿瘤学 | 166篇 |
出版年
2023年 | 42篇 |
2022年 | 67篇 |
2021年 | 154篇 |
2020年 | 75篇 |
2019年 | 103篇 |
2018年 | 120篇 |
2017年 | 68篇 |
2016年 | 90篇 |
2015年 | 99篇 |
2014年 | 144篇 |
2013年 | 143篇 |
2012年 | 236篇 |
2011年 | 219篇 |
2010年 | 127篇 |
2009年 | 99篇 |
2008年 | 124篇 |
2007年 | 108篇 |
2006年 | 100篇 |
2005年 | 89篇 |
2004年 | 91篇 |
2003年 | 80篇 |
2002年 | 69篇 |
2001年 | 57篇 |
2000年 | 43篇 |
1999年 | 36篇 |
1998年 | 29篇 |
1997年 | 20篇 |
1996年 | 11篇 |
1995年 | 11篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 17篇 |
1991年 | 18篇 |
1990年 | 25篇 |
1989年 | 17篇 |
1988年 | 11篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 14篇 |
1983年 | 3篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1974年 | 8篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1968年 | 3篇 |
排序方式: 共有2834条查询结果,搜索用时 15 毫秒
91.
92.
93.
94.
95.
96.
Kimona Issa Qais Naziri Aditya V. Maheshwari Vijay J. Rasquinha Ronald E. Delanois Michael A. Mont 《The Journal of arthroplasty》2013
The purpose of this study was to compare the outcomes of cementless primary total hip arthroplasty (THA) in sickle cell patients compared to the remaining cohort of osteonecrosis patients who did not have this disease. Thirty-two sickle cell patients (42 hips) who had a mean age of 37 years and mean follow-up of 7.5 years (range, 5–11 years) were compared to 87 non-sickle cell osteonecrosis patients (102 hips) who had mean age of 43 years and mean follow-up of 7 years (range, 3–10.5 years). Outcomes evaluated included implant survivorship, Harris hip scores, complication rates, radiographic outcomes, and Short Form-(SF-36) health questionnaire. There were no significant differences in aseptic implant survivorship (95 vs. 97%), Harris hip scores (87 vs. 88 points), SF-36 score, or radiographic findings between the two patient cohorts. In light of these findings, we believe that the outcomes of THA improved in sickle cell patients with optimized medical management and the use of cementless prosthetic devices. 相似文献
97.
Yair Lotan Aditya Bagrodia Niccolo Passoni Varun Rachakonda Payal Kapur Yull Arriaga Christian Bolenz Vitaly Margulis Ganesh V. Raj Arthur I. Sagalowsky Shahrokh F. Shariat 《European urology》2013
Background
Retrospective studies demonstrated that cell cycle–related and proliferation biomarkers add information to standard pathologic tumor features after radical cystectomy (RC). There are no prospective studies validating the clinical utility of markers in bladder cancer.Objective
To prospectively determine whether a panel of biomarkers could identify patients with urothelial carcinoma of the bladder (UCB) who were likely to experience disease recurrence or mortality.Design, setting, and participants
Between January 2007 and January 2012, every patient with high-grade bladder cancer, including 216 patients treated with RC and lymphadenectomy, underwent immunohistochemical staining for tumor protein p53 (Tp53); cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A); cyclin-dependent kinase inhibitor 1B (p27, Kip1); antigen identified by monoclonal antibody Ki-67 (MKI67); and cyclin E1.Intervention
Every patient underwent RC and lymphadenectomy, and marker staining.Outcome measurements and statistical analysis
Cox regression analyses tested the ability of the number of altered biomarkers to predict recurrence or cancer-specific mortality (CSM).Results and limitations
Pathologic stage among the study population was pT0 (5%), pT1 (35%), pT2 (19%), pT3 (29%), and pT4 (13%); lymphovascular invasion (LVI) was seen in 34%. The median number of removed lymph nodes was 23, and 60 patients had lymph node involvement (LNI). Median follow-up was 20 mo. Expression of p53, p21, p27, cyclin E1, and Ki-67 were altered in 54%, 26%, 46%, 15%, and 75% patients, respectively. In univariable analyses, pT stage, LNI, LVI, perioperative chemotherapy (CTx), margin status, and number of altered biomarkers predicted disease recurrence. In a multivariable model adjusting for pathologic stage, margins, LNI, and adjuvant CTx, only LVI and number of altered biomarkers were independent predictors of recurrence and CSM. The concordance index of a baseline model predicting CSM (including pathologic stage, margins, LVI, LNI, and adjuvant CTx) was 80% and improved to 83% with addition of the number of altered markers.Conclusions
Molecular markers improve the prediction of recurrence and CSM after RC. They may identify patients who might benefit from additional treatments and closer surveillance after cystectomy. 相似文献98.
99.
Kaukab M Hassan Aditya Verma Sudeep Prakash Vijai Chandran Suman Kumar Anup Banerji 《Annals of Indian Academy of Neurology》2013,16(4):516-520
Background:
Data is scarce on prevalence of extracranial carotid atherosclerosis (ECA) in strokes <50 years and its association with lifestyle factors.Objective:
Study role of (a) ECA in non-cardio-embolic anterior circulation young strokes, and (b) smoking and alcohol in ECA.Materials and Methods:
Cardiovascular risk factors and evidence of ECA on carotid doppler ultrasound (CDUS) was evaluated in an one-year preliminary cross-sectional study of consecutive strokes between 20 years and 49 years. Females were excluded.Results:
There were 46 male strokes (mean age 38.26 yrs), 17.39% had hypertension, 2.23% had coronary artery disease; none was diabetic. Tobacco users and alcohol consumers were 24/46 (52.17%) cases each. ECA was found in 14/46 (30.44%) cases. Seven of these 14 (50%) i.e., 7/46 cases (15.21%) had carotid occlusion, four had <50%, three had >70% stenosis. ‘Smoking and smokeless tobacco use’ was found in 71.42% (10/14) symptomatic carotid lesions compared to 43.75% (14/32) strokes without carotid lesions. Prevalence odds ratio for tobacco use and ECA was 3.21 (95% CI: 0.83-12.44) while that of alcohol and ECA was 1.33 (95% CI: 0.38-4.72).Conclusion:
Prevalence of ECA in strokes <50 years was high due to lifestyle factors which predispose to atherosclerosis at younger age.Key Words: Alcohol, extracranial carotid atherosclerosis, lifestyle factors, smoking, young stroke 相似文献100.
Selvakumar Arumugam Pulikanti Guruprasad Reddy Maria Francis Aditya Kulkarni Sudipta Roy Kartik Chandra Mondal 《RSC advances》2020,10(65):39366
Two alkyl substituted triaryl-cyclopentadienyl ligands [4,4′-(4-phenylcyclopenta-1,3-diene-1,2-diyl)bis(methylbenzene) (1) and 4,4′,4′′-(cyclopenta-1,3-diene-1,2,4-triyl)tris(methylbenzene) (2)] have been synthesized via cross-aldol condensation followed by Zn-dust mediated cyclization and acid catalyzed dehydration reactions. The fluorescence properties of 1 and 2 have been studied in solution and solid state. The ligands exhibited aggregation-induced emission enhancement (AIEE) in THF/water solution. 1 and 2 have been found to be significantly more fluorescent in the solid state than in their respective solutions. This phenomenon can be attributed to the strong intermolecular CH⋯π interactions present in 1 and 2 which leads to the tight packing of molecules in their solid-state. Both 1, 2 and their corresponding anions have been studied by theoretical calculations. Ligands 1 and 2 have been shown to react with anhydrous DyCl3 in the presence of potassium metal at high temperature to afford two fluorescent chloride-bridged tetra-nuclear mixed potassium–dysprosium metallocenes [(Me2Cp)4Dy2IIICl4K2]·3.5(C7H8) (5) and [(Me3Cp)4Dy2IIICl4K2]·3(C7H8) (6), respectively in good yields.Alkyl substituted triaryl-cyclopentadienyl ligands with aggregation-induced emission enhancement (AIEE) properties and their applications in the syntheses of novel chloride bridged tetra-nuclear mixed potassium–dysprosium metallocenes. 相似文献