全文获取类型
收费全文 | 25022篇 |
免费 | 1826篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 379篇 |
儿科学 | 673篇 |
妇产科学 | 540篇 |
基础医学 | 3092篇 |
口腔科学 | 288篇 |
临床医学 | 2543篇 |
内科学 | 5299篇 |
皮肤病学 | 484篇 |
神经病学 | 2333篇 |
特种医学 | 1242篇 |
外科学 | 4089篇 |
综合类 | 256篇 |
一般理论 | 23篇 |
预防医学 | 1788篇 |
眼科学 | 404篇 |
药学 | 1773篇 |
中国医学 | 29篇 |
肿瘤学 | 1689篇 |
出版年
2023年 | 294篇 |
2022年 | 558篇 |
2021年 | 1125篇 |
2020年 | 629篇 |
2019年 | 949篇 |
2018年 | 1049篇 |
2017年 | 709篇 |
2016年 | 739篇 |
2015年 | 924篇 |
2014年 | 1178篇 |
2013年 | 1470篇 |
2012年 | 2121篇 |
2011年 | 2164篇 |
2010年 | 1151篇 |
2009年 | 914篇 |
2008年 | 1417篇 |
2007年 | 1420篇 |
2006年 | 1340篇 |
2005年 | 1176篇 |
2004年 | 1039篇 |
2003年 | 881篇 |
2002年 | 788篇 |
2001年 | 246篇 |
2000年 | 155篇 |
1999年 | 191篇 |
1998年 | 148篇 |
1997年 | 109篇 |
1996年 | 109篇 |
1995年 | 78篇 |
1994年 | 63篇 |
1993年 | 59篇 |
1992年 | 112篇 |
1991年 | 99篇 |
1990年 | 92篇 |
1989年 | 103篇 |
1988年 | 74篇 |
1987年 | 88篇 |
1986年 | 76篇 |
1985年 | 75篇 |
1984年 | 70篇 |
1983年 | 53篇 |
1982年 | 56篇 |
1981年 | 60篇 |
1980年 | 41篇 |
1979年 | 52篇 |
1978年 | 47篇 |
1974年 | 37篇 |
1973年 | 52篇 |
1972年 | 47篇 |
1970年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 12 毫秒
981.
982.
Manoj K. Mittal MD Joel S. Tieder MD MPH Kathryn Westphal MD Erin Sullivan MPH Matt Hall PhD Risa Bochner MD Adam Cohen MD Jennifer Y. Colgan MD Atima C. Delaney MD Amy M. DeLaroche MBBS Thomas Graf MD Beth Harper MD Ron L. Kaplan MD Hannah C. Neubauer MD Mark I. Neuman MD MPH Nirav Shastri MD Victoria Wilkins MD MPH Allayne Stephans MD 《Academic emergency medicine》2023,30(6):662-670
983.
Thomas E. Smith Anita Appel Sheila A. Donahue Susan M. Essock Doreen Thomann-Howe Adam Karpati Trish Marsik Robert W. Myers Mark J. Sorbero Bradley D. Stein 《Administration and policy in mental health》2014,41(5):588-597
This study examined whether Medicaid claims and other administrative data could identify high-need individuals with serious mental illness in need of outreach in a large urban setting. A claims-based notification algorithm identified individuals belonging to high-need cohorts who may not be receiving needed services. Reviewers contacted providers who previously served the individuals to confirm whether they were in need of outreach. Over 10,000 individuals set a notification flag over 12-months. Disengagement was confirmed in 55 % of completed reviews, but outreach was initiated for only 30 %. Disengagement and outreach status varied by high-need cohort. 相似文献
984.
985.
986.
Beatriz Rodriguez-Grande Matimba Swana Loan Nguyen Pavlos Englezou Samaneh Maysami Stuart M Allan Nancy J Rothwell Cecilia Garlanda Adam Denes Emmanuel Pinteaux 《Journal of cerebral blood flow and metabolism》2014,34(3):480-488
Acute-phase proteins (APPs) are key effectors of the immune response and are routinely used as biomarkers in cerebrovascular diseases, but their role during brain inflammation remains largely unknown. Elevated circulating levels of the acute-phase protein pentraxin-3 (PTX3) are associated with worse outcome in stroke patients. Here we show that PTX3 is expressed in neurons and glia in response to cerebral ischemia, and that the proinflammatory cytokine interleukin-1 (IL-1) is a key driver of PTX3 expression in the brain after experimental stroke. Gene deletion of PTX3 had no significant effects on acute ischemic brain injury. In contrast, the absence of PTX3 strongly compromised blood–brain barrier integrity and resolution of brain edema during recovery after ischemic injury. Compromised resolution of brain edema in PTX3-deficient mice was associated with impaired glial scar formation and alterations in scar-associated extracellular matrix production. Our results suggest that PTX3 expression induced by proinflammatory signals after ischemic brain injury is a critical effector of edema resolution and glial scar formation. This highlights the potential role for inflammatory molecules in brain recovery after injury and identifies APPs, in particular PTX3, as important targets in ischemic stroke and possibly other brain inflammatory disorders. 相似文献
987.
Adam P. Vogel Sophie E. Brown Joanne E. Folker Louise A. Corben Martin B. Delatycki 《Journal of neurology》2014,261(2):392-399
Dysphagia in Friedreich ataxia (FRDA) and its impact on quality of life is not adequately understood. The objective of this study was to characterise dysphagia in FRDA and to determine the impact of swallowing dysfunction on activities, participation, and sense of well-being. Thirty-six individuals with a confirmed diagnosis of FRDA were assessed via a clinical bedside examination (CBE), the Royal Brisbane Hospital outcome measure for swallowing, an oral-motor examination and the Australian therapy outcome measures for speech and swallowing (AusTOMS). Data on swallowing function, diet modification and swallowing strategies were collated. Thirty-three (91.67 %) participants exhibited clinical signs of dysphagia according to the CBE, and all participants received ratings indicating swallowing difficulties on at least one other measure. Dysphagia in FRDA is characterised by oral and pharyngeal stage impairment relating to incoordination, weakness and spasticity. A significant positive correlation was found between the severity of impairment, activity, participation and distress/well-being on the AusTOMS, suggesting that swallowing function decreases with overall reductions in quality of life. A significant correlation was found between activity on the AusTOMS and disease duration (r = ?0.283, p = 0.012). No significant correlations were found between dysphagia severity and GAA repeat length, age of onset or disease severity. Participants employing diet modification and swallowing strategies demonstrated higher dysphagia severity, activity limitations and participation restrictions. These data advocate a holistic approach to dysphagia management in FRDA. Early detection of swallowing impairment and consideration of the potential impact dysphagia has on quality of life should be key aspects in disease management. 相似文献
988.
Sébastien Lenglet Fabrizio Montecucco Adam Denes Graham Coutts Emmanuel Pinteaux Fran?ois Mach Karl Schaller Yvan Gasche Jean-Christophe Copin 《Journal of cerebral blood flow and metabolism》2014,34(5):802-812
The effect of recombinant human tissue plasminogen activator (rtPA) on neuroinflammation after stroke remains largely unknown. Here, we tested the effect of rtPA on expression of cellular adhesion molecules, chemokines, and cytokines, and compared those with levels of inflammatory cell recruitment, brain injury, and mortality over 3 days after transient middle cerebral artery occlusion (MCAO) in mice. Mortality was dramatically increased after rtPA treatment compared with saline treatment during the first day of reperfusion. Among the animals that survived, rtPA significantly increased CCL3 expression, microglia recruitment, and cerebral infarction 6 hours after MCAO. In contrast, the extent of neutrophils and macrophages infiltration in the brain was similar in both saline- and rtPA-treated animals. Recombinant human tissue plasminogen activator induced Il1b and Tnf expression, 6 and 72 hours after MCAO, respectively, and dramatically reduced interleukin 6 (IL-6) level 24 hours after reperfusion. A dose response study confirmed the effect of rtPA on CCL3 and Il1b expressions. The effect was similar at the doses of 1 and 10 mg/kg. In conclusion, we report for the first time that rtPA amplified microglia recruitment early after stroke in association with a rapid CCL3 production. This early response may take part in the higher susceptibility of rtPA-treated animals to reperfusion injury. 相似文献
989.
990.
Adam Schwartz Thomas Schiano Leona Kim‐Schluger Sander Florman 《Clinical transplantation》2014,28(10):1075-1079
Due to the current regionally based allocation system, some patients list for and are transplanted away from home in regions with shorter waits and higher transplant rates. Of 147 included patients, 120 died waiting and 27 received transplants at outside centers during the study (32.5 months). Those transplanted elsewhere had higher median incomes than patients dying on the waitlist ($84 946 vs. $55 250, p = 0.0001). Those with median incomes <$60 244 were more likely to die than those with incomes >$60 244 (94% vs. 70%, RR: 1.35, 95% CI: 1.14–1.59). Patients with Medicaid were more likely to die waiting than those with other insurance (100% vs. 77%, RR: 1.30, 95% CI: 1.18–1.44). Our analysis demonstrates that those who died waiting were more likely to have lower incomes and Medicaid compared with those transplanted elsewhere. Even when we controlled for Medicaid status, patients who died waiting had lower incomes compared with those transplanted elsewhere. Increased organ sharing over geographically broader regions, as recommended by the Institute of Medicine in 1999, may reduce incentives for patients to travel to receive a liver and reduce inequities. Current efforts to address this disparity continue to fall short of the Institute of Medicine recommendations, United States Department of Health and Human Services regulations and the Final Rule. 相似文献