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271.
17-beta-estradiol in relation to age at menarche and adult obesity in premenopausal women 总被引:1,自引:0,他引:1
Emaus A Espetvedt S Veierød MB Ballard-Barbash R Furberg AS Ellison PT Jasienska G Hjartåker A Thune I 《Human reproduction (Oxford, England)》2008,23(4):919-927
BACKGROUND: We hypothesize that premenopausal endogenous estradiol may beassociated with age at menarche and adult overweight and obesity,potentially contributing to breast cancer risk. METHODS: We assessed age at menarche by questionnaire among 204 healthyNorwegian women, aged 25–35 years. Measures of body compositionincluded body mass index (BMI, kg/m2), waist circumference (WC,cm), waist-to-hip ratio (WHR) and fat percentage dual energyX-ray absorptiometry, (DEXA). Daily salivary 17-β-estradiol(E2) concentrations were collected throughout one entire menstrualcycle and assessed by radioimmunoassay (RIA). Linear regressionanalyses and linear mixed models for repeated measures wereused and potential confounding factors and effect modifierswere tested. RESULTS: Among women with an early age at menarche (12 years), the overallmean salivary E2 concentration increased by 3.7 pmol/l (95%confidence interval, 1.8–5.7 pmol/l) with each 9.8 cm(1 SD) increase in WC, which represents a 20.7% change in themean for the total group. Among the same early maturers, a 1SD (0.06) change in WHR was directly associated with a 24.0%change in mean E2 concentration for the total group. CONCLUSIONS: Our findings support the hypothesis that early age at menarche,together with adult overweight and obesity, result in high levelsof 17-β-estradiol throughout the menstrual cycle. 相似文献
272.
Emmanuel Desandes Laurence Brugières Florence Molinié Gautier Defossez Patricia Delafosse Karine Jehannin‐Ligier Michel Velten Brigitte Trétarre Brice Amadéo Emilie Marrer Anne‐Sophie Woronoff Olivier Ganry Alain Monnereau Tania d'Almeida Xavier Troussard Laetitia Daubisse‐Marliac Simona Bara Anne‐Valérie Guizard Isabelle Baldi Guy Launoy Jacqueline Clavel Brigitte Lacour 《Pediatric blood & cancer》2018,65(9)