右上肺癌介入治疗后并发横断性脊髓炎的治疗及护理

 1999年 7月我科收治 1例右上肺癌患者 ,住院后行介入治疗并发横断性脊髓炎 ,现将治疗及护理体会报告如下 :     

体部γ刀治疗原发性小肝癌的疗效观察

小肝癌(small hepatocellular carcinoma,SHCC)指肿瘤结节单个最大直径≤3cm,多个结节数目≤2个且总和<3cm.其治疗方法较多,首选用手术切除其次为肝脏移植治疗或介入治疗,对小宜手术者则采用瘤内无水酒精注射或射频或介入治疗的生存率较高.研究认为立体定向放疗安全、有效,故笔者尝试对不愿或不能手术的SHCC,笔者采用体部γ刀进行放疗,现将治疗结果报道如下.     

微波消融联合立体定向放疗治疗介入后原发和复发性肝癌的临床研究

Abstract：Objective To assess microwave ablation combined with stereotactic radiotherapy for primaryand recurrent hepatocellular carcinoma after interventional treatment. Methods The clinical data of106 primary and recurrent liver cancer patients in the fifth Hospital of Wuhan City in recent years wereretrospectively analyzed．All patients were equally divided into control group (CG) and observationgroup(OG). OG group received stereotactic radiotherapy which was conformal intensity modulatedradiotherapy, and then microwave ablation. CG group only received stereotactic radiotherapy. Short-termeffects,survival rates and clinical features were compared between two groups. Results Total responserates of CG and OG were 62.26% and 79.25%(P <0.05)．1-year survival rate of OG group was higherthan that in CG group(P <0.05).Quality of life in two groups before and after treatment and serum AFPhad no statistical significance(P>0.05). Incidences of nausea,vomiting, fever,leucocyte decline,radioactivehepatitis and peptic ulcer in two groups during and after treatment had no statistical signifi cance(P >0.05).Conclusion Curative effect of microwave ablation combined with stereotactic radiotherapy regimen forprimary and recurrent hepatocellular carcinoma is reliable,with mild adverse reactions, and worthy of furtherclinical research．     

中西医结合治疗中晚期肝癌临床观察

自2006年3月-2008年5月间,我们对不能手术的原发性肝癌患者,采用超级伽玛刀联合中医辨证治疗,对获得随访的85例肝癌患者进行回顾性分析,并与同期仅行超级伽玛刀治疗的81例进行对照比研究。现报道如下。     

二甲苯基碘减轻放射性肺损伤作用的实验研究

目的 观察NADPH氧化酶抑制剂二甲苯基碘（DPI）对放射性肺损伤的防治作用,探讨其可能机制。方法 48只成年雄性SD大鼠按随机数字表法分为空白对照组（C组）、单纯照射组（R组）、照射+二甲苯基碘组（R+D组）和单用二甲苯基碘组（D组）,每组12只。采用6 MV X射线照射双肺,每只每天照射8 Gy,连续照射5 d,总剂量40 Gy。R+D组大鼠在每次照射前1 h皮下注射0.02% DPI溶液（1 mg/kg）;D组大鼠不接受射线照射,只注射DPI溶液。两组大鼠DPI注射从照射前3 d开始,持续至照射后30 d。C组和R组大鼠则注射等体积的生理盐水。照射后1个月和6个月时提取肺组织,行HE染色、Masson染色、羟脯氨酸含量测定和TGF-β1免疫组织化学染色。结果 在照射后1个月时,R组出现典型肺泡炎表现,羟脯氨酸含量为（0.69±0.05）μg/mg,TGF-β1阳性染色面积比为（39.97±0.90）%,R+D组羟脯氨酸含量为（0.55±0.03）μg/mg,TGF-β1阳性染色面积比为（33.83±1.55）%,肺泡炎程度轻于R组（t=5.32、5.93,P<0.05）。6个月时R组出现典型肺纤维化表现,羟脯氨酸含量为（1.04±0.02）μg/mg,TGF-β1阳性染色面积比为（37.80±0.85）%,R+D组羟脯氨酸含量为（0.85±0.02）μg/mg,TGF-β1阳性染色面积比为（23.93±1.16）%,肺纤维化程度轻于R组（t=15.77、16.68,P<0.05）。C组和D组则未发生明显异常变化。结论 二甲苯基碘可以减少大鼠肺部照射后羟脯氨酸及TGF-β1的含量,减轻肺损伤的程度,对放射性肺损伤具有一定的防治作用。