综合性教学医字研究生导师队伍建设的初步探讨

新疆维吾尔自治区人民医院是一所学科齐全,技术力量雄厚,诊疗设备精良,集医疗、教学、科研、预防保健和社区服务为一体的大型综合性"三级甲等"医院,是新疆医科大学和石河子大学的研究生培养基地,研究生教育在医院的建设和发展中具有战略地位.     

下颌尖牙双根1例

男性患者，52岁，因反复出现下前牙肿痛、颏部流脓2年入院。 查体：颏部正中稍偏左约1cm肿胀，见一瘘管，挤压有脓性分泌物流出，探诊经瘘管可探至骨面。口内检查：牙式，左下3颜色稍发暗，松动（-），叩痛（±），牙龈无红肿，其颊侧根方移行部粘膜略红于周围粘膜，轻度肿胀，触痛（±）。     

急性心肌梗死病人的护理

急性心肌梗死是由于心肌持久、严重缺血而引起部分心肌坏死,在冠状动脉粥样硬化的基础上合并血栓而形成持续性痉挛,使管腔发生急性阻塞.急性心肌梗死是目前危害人类健康的主要疾病之一,临床上无明显诱因,突然出现剧烈的心前区疼痛,持续性疼痛可放射至左肩、背部、锁骨下及腹部,伴面色苍白,大汗淋漓、脉搏细弱、血压下降、呼吸急促、发绀[1],一旦诊断心肌梗死,必须分秒必争进行抢救.     

氟化物细胞毒性和遗传毒性的研究进展

目前，研究者对氟化物的细胞毒性已达成共识，但对其遗传毒性尚未定论，争议颇多。参阅了国内外有关文献，对氟的细胞毒性及遗传毒性加以综述。     

涎腺肿瘤3461例临床病例分析

目的 :了解涎腺肿瘤发病情况、构成特点及发展趋势。方法 :对四川大学华西口腔医院 195 5～ 2 0 0 2年间收治的 3 461例涎腺肿瘤临床资料进行回顾性分析。结果 :良恶性的平均发病年龄分别是 41.3 8岁和 45 .2 0岁 ,良恶性的男女之比分别是 0 .99∶1和 1.3 4∶1。腮腺、腭部的小涎腺和颌下腺分别列为涎腺肿瘤原发部位前3位 ;多形性腺瘤、腺淋巴瘤、基底细胞腺瘤与粘液表皮样癌、腺样囊性癌、腺癌分别列为良、恶性肿瘤前三位。结论 :涎腺肿瘤发病有增加的趋势 ;男性患者的构成比恶性肿瘤高于良性 ;女性患者构成比有增加趋势 ;腮腺和腭部分别是大、小涎腺肿瘤的高发部位 ;多形性腺瘤和粘液表皮样癌是最常见的涎腺良、恶性肿瘤。     

中药汤剂使用依从性现状及提高方法

中药汤剂能充分适应辨证施治需要,疗效快,易吸收,作用强等特点,应用广泛。以往对中药汤剂研究集中在配伍、炮制及煎煮方面,对患者用药依从性研究较少。中药汤剂使用依从性是治疗基础。中药汤剂使用存在非依从性现象。提高病人依从性:①注重汤剂抓取、制备简单化,改善汤剂外观,适当加入辅料改善口感。②注重汤剂服用、吸收方便性。加入某一种药物配伍以改善汤剂的外观和口感。③注重汤剂费用低廉、效果灵验。有效沟通医、药、病三者关系,及时地解释处方用药的原因和意义,耐心解答病人的咨询。     

Down-Regulation of Notch1 and NF-κB by Curcumin in Breast Cancer Cells MDA-MB-231

Objective  To test whether the down-regulation of Notch1 gene expression by curcumin could inhibit cell growth and induce apoptosis, which may be associated mechanistically with the down-regulation of NF-κB in breast cancer cells. Methods  Breast cancer cell lines MDA-MB-231 were cultured in vitro and treated with different dosages of curcumin (0, 1.25, 5.0, 20.0μmol/L) for dose-dependent assay and different time (0, 24, 48, 72 h) at the dosage of 5.0μmol/L for time course assay. The changes of the mRNA and protein expression of Notch1 and NF-κB were measured by RT-PCR and Western Blot, and MTT assay was used to measure the change of proliferation. Results  The mRNA and protein levels of Notch1 and NF-κB were decreased significantly in human breast cancer cell line with the increase of dosage of curcumin(P<0.05), and with the extension of time course(P<0.05). These changes suggested a dose- and time-dependent manner. The proliferation rate of cells also was significantly inhibited(P<0.05). Conclusion  The current results show that the Notch-1 signaling pathway is associated mechanistically with NF-κB activity during curcumin-induced cell growth inhibition and apoptosis of breast cancer cells. These results suggest that the down-regulation of Notch signaling by curcumin may be a novel strategy for the treatment of patients with breast cancer.      

Down-Regulation of Notchl and NF-κB by Curcumin in Breast Cancer Cells MDA-MB-231

Objective:To test whether the down-regulation of Notch1 gene expression by curcumin could inhibit cell growth and induce apoptosis,which may be associated mechanistically with the down-regulation of NF-κB in breast cancer cells. Methods:Breast cancer cell lines MDA-MB-231 were cultured in vitro and treated with different dosages of curcumin(0,1.25,5.0,20.0μmol/L)for dose-dependent assay and different time(0,24,48,72 h)at the dosage of 5.0μmol/L for time course assay.The changes of the mRNA and protein expression of Notch1 and NF-κB were measured by RT-PCR and Western Blot,and MTT assay was used to measure the change of proliferation. Results:The mRNA and protein levels of Notch 1 and NF-κB were decreased significantly in human breast cancer cell line with the increase of dosage of curcumin(P＜0.05),and with the extension of time course(P＜0.05).These changes suggested a dose- and time-dependent manner.The proliferation rate of cells also was significantly inhibited(P＜0.05). Conclusion:The current results show that the Notch-1 signaling pathway is associated mechanistically with NF-κB activity during curcumin-induced cell growth inhibition and apoptosis of breast cancer cells.These results suggest that the down-regulation of Notch signaling by curcumin may be a novel strategy for the treatment of patients with breast cancer.     

中医外治法治疗糖尿病周围神经病变新进展

糖尿病周围神经病变是糖尿病最常见的慢性并发症之一,具有高患病率和致残率等特点,有效防治本病已成为现阶段重要的公共卫生问题之一。中医外治法以其副作用小、费用低等优势在糖尿病周围神经病变的防治中发挥着不可替代的作用,本文综述近年来中医外治法治疗本病的概况,为中医外治法治疗本病的临床应用及深入研究提供依据。