血清CA153在肺部良、恶性疾病鉴别诊断中的意义

目的：探讨血清CA153作为肿瘤标志物在肺部良、恶性疾病鉴别诊断中的临床意义，以及在肺癌病情判断中的临床应用价值。方法：采集有肺癌疾病入院患者的血清样本共124份，其中肺癌74份，肺癌良性疾病（BLD）50份，用免疫放射法检测其血清CA153、CEA的含量。结果：肺癌患者血清CA153总阳性率62.68%，其中鳞癌50％，腺癌75％，小细胸肺癌50％，明显高于BLD组的12％（P＜0.001）；血清CA153诊断肺部的敏感度和特异度分别为62.68%和88％，血清CEA的敏感度和特异度分别为45.07%和98％,血清CA153敏感度明显优于血清CEA（P＜0.05），而特异度差别无显著性（P＞0.9）；对于不同的细胞亚型，肺腺癌患者血清CA153含量明显高于其他肺癌组（P＜0.05）；血清CA153的含量和阳性率与肺癌临床分期有关，期别越高其含量和阳性率越高（P＜0.05），其早期诊断阳性率为50％；随访化疗患者，血清CA153的含量与疗效呈负相关。结论：血清CA153对肺癌的诊断及病情预后判断有较高的临床价值，可以取代血清CEA作为检测肺癌，尤其是肺腺癌新的血清肿瘤标志物。     

组织多肽特异性抗原对胰腺癌患者的诊断价值

Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma.     

血清PSA测定质量控制分析研究

如何保证自动化免疫分析测定质量 ,使测定结果有良好的重复性及可比性 ,对科研及临床应用都具有重要意义。本研究结合参加ＩＡＥＡ的ＰＳＡ测定外部质量评价 (ＥＱＡ)课题 (ＩＡＥＡＲｅｓｅａｒｃｈＣｏｎｔｒａｃｔＮｏ 93 17/ＲＩ) ,对 1998年 5～ 12月间常规测定中内、外质量评估参数进行了分析 ,并对测定质量中出现的问题提出了改进意见。材料与方法1 仪器。ＥＧ＆ＧＷａｌｌａｃ自动时间分辨荧光免疫分析仪 (ＡｕｔｏＤＥＬＦＩＡ 12 3 5 )。2 试剂。总ＰＳＡ (Ｔ ＰＳＡ)及游离ＰＳＡ(Ｆ ＰＳＡ)测定采用Ｗａｌｌａｃ公司Ｐｒｏｓｔ…     

TrFIA和CLEIA检测血清PRL和GH的结果比较

血清垂体泌乳素（PRL）和生长激素（GH）同时采用时间分辨荧光免疫分析（TrFIA）和酶放大发光免疫分析（CLEIA）进行定量，比较了两种方法的相关性和一致性。     

组织多肽特异性抗原对胰腺癌患者的诊断价值

Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma.     

组织多肽特异性抗原对胰腺癌患者的诊断价值

Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma.     

第五届全国核医学学术会议纪要

第五届全国核医学学术会议纪要中华医学会、中国核学会核医学学会召开的第五届全国核医学学术会议于１９９７年５月９～１３日在上海举行。会议共收到论文８２７篇，其中会议交流２６２篇，壁报展示１８５篇。下面简要介绍会议交流的主要内容。神经核医学神经核医学交流论...     

正常孕妇妊娠各期、产后和新生儿脐血中血清甲状腺激素测定的临床意义

本文测定了94例正常孕妇(第一期27例,第二期27例,第三期40例),29例产妇(产后2天),14例新生儿脐血的血清TT_3、TT_4和~(125)I-T_3MAA吸收比值,并计算FT_3I和FT_4I,与已发表过的正常值作比较。结果正常人妊娠期血清~(125)I-T_3MAA吸收比值下降,血清TT_4、TT_3升高,分别为0.78±0.136、12.05±3.57μg/dl、178.56±35.56ng/dl对0.96±0.06、9.23±     

67例慢性淋巴细胞性甲状腺炎的诊断和治疗

本文报告67例确诊的慢性淋巴细胞性甲状腺炎。男∶女=1∶21.3,40—46岁占64.2%;本病多起病缓慢、隐匿,有不同程度的甲状腺肿,多呈结节性,病程中可有假性甲亢或甲减的表现,也可合并甲亢、甲状腺腺瘤及甲状腺癌。本文对其自身免疫发病机制进行了讨论,对诊断标准提出了补充意见。本病一旦确诊后应行甲状腺激素终身替代治疗,以免复发或导致甲减。     

妊娠期甲亢

本文收集56例以往有甲亢史或孕期有高代谢征群的妇女,按甲状腺功能状态分二组:23例活动性Graves病组,33例对照组,逐月随访甲状腺功能指标直至分娩或产后1月。结果:甲亢组(尤其是中重型及症状未控制者)有较高的流产率(13％对0％),妊高症(34.8％对15.2％),小样儿(8.7％对3.3％),早产(17.39％