BIOEQUIVALENCE BETWEEN rhGH FOR RECONSTITUTION AND READY-TO-USE rhGH IN TWO LIQUID FORMULATIONS

Objective To evaluate the bioequivalence between recombinant human growth hormone （rhGH） for reconstitution, and two dosages of liquid formulation of rhGH [ （151U） 5mg or （301U） lOmg per 3ml ]. Methods The study drugs were tested in a randomized, single-blind and three-period crossover studies in 24 healthy male subjects. The three drugs were administered by subcutaneous injection at a dose of O. 21U/kg body weight. A continuous somatostatin infusion was given in order to suppress the secretion of endogenous GH. The ve- nous blood samples were drawn at different time points to test the serum concentration of GH. The pharmacokinetic parameters were analyzed by statistical methods. Results 90% confidence intervals （CI） of AUC0-24h among three products were all within 80% - 125% interval （ 103. 4% - 116. 5%, 105. 7% - 119. 6% and 91.9% - 103. 7%, respectively）, and the Cls of C,~ among three products were all within 70% - 143% interval （91.9% - 114. 0%, 103. 7% -127. 2% and 81.6% -97. 4%, respectively）. There was no statisitical difference of tmax among all the three products. Conclusion These data demonstrate that there is bioequivalence between rhGH for reconstitution and two liquid formulations of rhGH.     

手术室护士职业危险因素的防护

手术室是医院特定环境，它不仅是挽救病人生命和手术治疗疾病的重要场所，同时也是一个高危区，细菌、病毒感染、化学制剂和挥发性麻醉剂对空气的污染以及电灼、噪音等危害工作人员的因素大量存在，对长期工作在手术室一线的护理人员的健康造成一定程度的危害。现就这些危险因素对健康的影响与大家进行学习和探讨。     

敷贴疗法在儿科的临床应用体会

敷贴疗法是采用中药研粉或调成糊状贴敷于体表，经皮吸收后达到治疗目的的一种中医外治方法。现就敷贴疗法在儿科的临床应用浅述如下。     

锰电焊工人某些内分泌功能研究

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体表胃电传导特性的研究

本文以胃钡餐X线照片为依据,选择胃体中央、胃体窦交界处和胃窦中央作为电极定位点,分别为E_1、E_2、E_3点,同步检测胃电图。实验结果表明:胃电慢波E_1先出现,呈现从E_1点向E_3点传导的现象;胃电慢波幅值E_1,E_2、E_3点餐前分别为274±55、554±196、726±145μV,餐后分别为294±41、606±188,801±240μV;试餐前及试餐后,各点胃电图优势频率均值之间差别无统计学意义(P>0.05)。提示体表胃电存在传导特性,传导方向从胃体中央扩播至胃窦中央。越近胃窦波幅越高,但优势频率不变。     

心理干预对原发性高血压60例血压控制的影响

随着现代医学模式的转变,心理因素对原发性高血压的影响越来越重要。我们对原发性高血压60例患者,在常规服用抗高血压药物的基础上给予心理干预,取得了满意效果。现分析报告如下。1临床资料1.1一般情况选择来我院疗养的原发性高血压患者的低危组及中危组,排除高危组及极高危组;