Thrombocytopenia after therapeutic hypothermia in severe traumatic brain injury

Objective: To investigate the clinical characteristics and significance of thrombocytopenia after therapeutic hypothermia in severe traumatic brain injury (TBI). Methods:Ninety-six inpatients with severe brain injury were randomized into three groups: SBC (selective brain cooling) group (n=24), MSH (mild systemic hypothermia ) group (n=30), and control (normothermia) group (n=42). The platelet counts and prognosis were retrospectively analyzed. Results: Thrombocytopenia was present in 18 (75%), 23 (77%) and 15 (36%) patients in SBC group, MSH group and control group, respectively (P<0. 01). Thrombocytopenia, in which the minimum platelet count was seen 3 days after hypothermia, showed no significant difference between SBC and MSH group (P>0.05). Most platelet counts (37 cases, 90 %) in hypothermia group were returned to normal level after 1 to 2 days of natural rewarming. The platelet count in SBC group reduced by 16%, 27% and 29% at day 1, 3 and 5 respectively compared with the baseline value. Good recovery ( GOS score 4-5) rate of thrombocytopenia 1 year after injury for hypothermia group (17 cases, 37%) was significantly lower than that of control group (P < 0.01). Conclusions: Therapeutic hypothermia increases the incidence of thrombocytopenia in severe TBI, and patients with thrombocytopenia after therapeutic hypothermia are associated with unfavorable neurological prognosis.     

缺血性脑白质病变的影像学评估

概述 随着CT、MR新技术的发展,神经影像学已不只是显示单纯的解剖结构,而且能够提供生理、生化等功能方面的信息.     

Epidemiology of age-related dementia in China.

Since the early 1980s, China has confronting adramatic change in population structure as well as arapid aging process. The proportion of the elderlyhas been increasing nation wide, and dementia is be-coming a major public health problem. However,the distribution of dementia among the aged, itsprevalence and incidence were unknown.Anepidemiological program was initiated in 1986 to in.vestigate this disorder in a community--based agedpopulation and to identify the possible risk factorsof Alzheimer's disease through collaboration withnine psychiatric hospitals in China, headed by the In-stitute of Mental Health, Beijing Medical University.     

绵毛黄芪苷和苦玄参苷的中枢抑制作用

报道了绵毛黄芪苷(SK)及其同类结构苦玄参苷(PIA)给予昆明种式BLC_(57)/1小鼠50mg/kg腹腔注射能明显延长硫贲妥钠的睡眠时间,用扭体法或热板法证实同量SK或PIA静脉注射能产生明显的镇痛作用。用格斗试验证实:同量SK或PIA腹腔注射可使小鼠格斗试验次数明显减少。提示两种苷可能具有中枢镇静、镇痛和安定作用;此类中枢抑制作用说明四环三萜皂苷类具有药用价值的前景。     

前牙反缺失修复法

作者用“粘膜术与牙体修复术”相结合方法，成功地修复了成人畸形的前牙和个别前牙缺失的修复问题。经过一年来20例临床病例观察，达到快速满意的疗效。现报告如下。修复方法一、对畸形、错位的成人前牙修复法；1．局麻下唇面开髓，作常规根管治疗，很充后观察一周。2．用邻牙或相对牙作参照牙，切割转位牙、斜输锥形牙的影响修复部份的唇侧牙冠；反路牙调磨解除反。所有牙切端均用砂轮磨短并形成舌侧切斜面，以便将来用复会树脂粘固塑料牙片时切端包绕过来，以加强切端固应力、（注：本文所用的复合树脂是上海青浦齿科材料厂出产的H一18超…     

K562／ADM耐药细胞株的建立及其生物学特性的初步观察

我们建立的K562/ADM耐药细胞株,在ADM浓度为2.4μg/m1(4.46μM)中已稳定培养3.5个月,传了30—35代,K562/ADM亦具有多药耐受件(Multidrug Resistance,MDR)的特点,对ADM、VCR、AT—1258和DDP的耐受性分别为K562的114.7、94.0、13.3和7.4倍,但对5—FU不产生交叉耐药。K562和K562/ADM的倍增时间分别为19.2h和52.8h,集落生成率分别为37.5％和11.1％,K562染色体数为34—68,中位数为56;K562/MDM染色体数为32—90,中位数为50,K562/ADM可做为耐药机理和克服耐药措施研究的极好模型。     

死胎引产致宫腔积气一例

患者26岁,住院号860235。妊娠21周死胎,经腹宫腔内注射0.1%雷夫奴尔100ml 引产46小时,因腹胀来院。既往健康。查体T37.3℃,P72次/分,Bp110/70mmHg,心肺正常。腹部膨隆,腹围128cm。叩诊鼓音,宫底脐上四指,胎位不清,未闻及胎心音。WBC15.5×10~9/L,N80%,L20%。X 线所见:膈肌上升,运动受限,全腹透过度明显增强;可见胎儿颅骨重叠,脊柱弯曲成角,胎儿肢体模糊不清。孕妇出现阵发性宫缩,间隔7～8分,持续2～3分钟,伴有轻度坠胀感。腹部逐渐增大,宫底升高达剑下,病人呼吸困难且逐渐加重。经胃肠减压,肛管排气,灌肠等处     

苯并恶唑类化合物的研究——Ⅰ.化合物的合成及光物理性能

合成了四种结构类型的苯并恶唑化合物共15个:测试了它们的红外吸收光谱,以及它们在DMF中的紫外吸收、荧光发射和激光发射光谱。苯基取代物的荧光量子产率在0.64～0.66,无激光性能。其余的化合物荧光量子产率都大于0.70,在最大吸收波长下的激光转换效率为2.5～5.9%。