髓系来源的抑制性细胞在肿瘤进展过程中的研究

进展性肿瘤显著的特性是逃避机体免疫系统的监视、躲避免疫系统的杀伤、抑制自体免疫系统。肿瘤在进展过程中一群髓系来源的抑制性细胞（MDSC）在肿瘤微环境、引流区淋巴结大量聚集,其能够促进肿瘤的发展同时抑制机体的免疫作用。其机制概括为：髓系细胞向正常树突状细胞或巨噬细胞的分化受阻,分泌促进肿瘤生长的细胞因子,参与肿瘤血管的形成,诱导调节性T淋巴细胞（Treg）的产生,从而抑制了T淋巴细胞的抗肿瘤作用。     

象征性游戏在孤独症谱系障碍早期识别诊断中的作用

目的探索孤独症谱系障碍(ASD)儿童象征性游戏能力的影响因素,及其在疾病早期识别与诊断中的应用。方法回顾2015年4月到2017年8月就诊的123例发育行为儿保科门诊儿童的临床资料,其中66例发育迟缓(GDD)儿童包括ASD伴GDD 36例、单纯GDD 30例,57例不伴GDD儿童包括ASD不伴GDD 31例、原发性语言障碍(DLD)26例。比较各组间象征性游戏能力和Gesell婴幼儿发育水平,并探究象征性游戏能力的相关因素及对疾病的区分作用。结果在GDD儿童中,ASD伴GDD组象征性游戏检查(SPT)发展月龄低于单纯GDD组,且SPT发展月龄严重落后比例高于单纯GDD组。不伴GDD儿童中,ASD不伴GDD组SPT发展月龄低于DLD组,SPT发展月龄严重落后比例也高于DLD组;差异均有统计学意义(P0.05)。在ASD儿童中,象征性游戏能力与儿童各能区的发育水平呈显著正相关(r=0.393~0.630,P0.01),与ASD症状呈显著负相关(r=-0.390~-0.387,P0.01)。二项逻辑回归分析发现,在GDD儿童中SPT发展月龄对单纯GDD和ASD伴GDD两类疾病具有区分效应(OR=0.39,95%CI:0.745~0.992,P=0.034);在不伴GDD的儿童中区分效应无显著性(P0.05)。结论象征性游戏能力在ASD儿童中落后于发育水平相当的GDD和DLD儿童,且象征性游戏能显著区分伴有GDD的ASD,可为ASD早期识别提供线索。     

微波治疗宫颈糜烂87例

目的：观察用WB--3200A．B微波治疗仪治疗“宫颈糜烂”的疗效。方法：自2009年3月～2010年5月对来我院“宫颈糜烂”87例患者使用微波技术治疗。结果：取得了很好的疗效。结论：微波手术治疗仪止血性能好,且操作简单,对宫颈糜烂疗效显著。     

出生体重与5至8岁儿童超重和肥胖关联的队列研究

目的以回顾性队列研究探讨出生体重与5~8岁儿童超重和肥胖的关系。方法利用上海市闵行区所辖的13家社区卫生服务中心3~12岁儿童的体格检查数据库,截取5~8岁儿童的身高和体重数据进行分析。体检时行问卷调查生育史、出生体重、妊娠情况和出生后喂养史。按照出生体重分为:2 500 g(低出生体重儿)、~3 000 g、~3 500 g、~4 000 g和≥4 000 g组(巨大儿)。采用多元logistics分析评估出生体重与5~8岁儿童超重和肥胖的关系,并调整相关因素的影响。结果 99 897名5~8岁儿童进入分析,超重发生率为10.1%,肥胖发生率为5.0%。11.4%的儿童为低出生体重,7.3%为巨大儿;出生体重2 500 g、~3 000 g、~3 500 g、~3 500 g、~4 000 g和≥4 000 g组超重检出率分别为8.4%、7.6%、9.2%、11.5%和14.5%;肥胖检出率分别为4.7%、3.9%、4.4%、5.9%和7.9%。2简单相关分析发现,~3 500 g、~4 000 g和≥4 000 g组出生体重与儿童体重呈正相关(P0.000 1),在调整了性别、年龄、身高、分娩史、孕周、喂养史和身高后,仍具有显著相关性。3与出生体重~3 500 g组相比,~4 000 g组超重和肥胖的发生率增加31%和43%,~4 500 g组超重和肥胖的发生率增加76%和103%;~3 000 g组发生超重和肥胖的风险最低(RR=0.80,95%CI:0.73~0.88,P0.000 1;RR=0.87,95%CI:0.77~0.98,P0.000 1),调整了年龄、性别、孕周和产式等因素后,仍具有相关性;5、6、7和8岁儿童~4 000 g和≥4 000 g组发生超重和肥胖的风险相近;2 500 g组肥胖的风险RR为1.07(95%CI:0.79~1.43),P=0.27。结论出生体重对5~8岁儿童超重和肥胖的影响呈非线性关系。出生体重3 500 g儿童5~8岁超重和肥胖的风险显著增高。     

以骨碱性磷酸酶测定判定小儿佝偻病疗效的研究

以骨碱性磷酸酶测定判定小儿佝偻病疗效的研究湖南省湘乡市人民医院（４１１４００）黄俊辉张琴刘小阳吴采霞沈春芳湖南省湘潭市妇幼保健院李灿明软骨细胞和成骨细胞表面可形成基质小泡。泡内含丰富的骨碱性磷酸酶（ＢＡＬＰ）。ＢＡＬＰ可使有机磷分解为无机磷，并通过小...     

血清视黄醇结合蛋白4在妊娠糖尿病患者中显著升高

To investigate the relationship between serum retinol-binding protein 4(RBP4) and gestational diabetes mellitus (GDM) in Chinese Han pregnant women.195 (23-42 years) pregnant women were recruited (July 2005 to December 2007) from the Department of Gynecology and Obstetric in Ruijin Hospital during their visiting for routine prenatal examination.99 subjects belonged to GDM group,and 96 belonged to the group with normal glucose tolerance (NGT).65 non-pregnant healthy women served as control.Serum RBP4 was measured using sandwich enzyme linked immunosorbent assay (ELISA).Pregnant women had higher level of serum RBP4 than that of non-pregnant control.The concentration of serum RBP4 was significantly increased in GDM group as compared with NGT group[(43.04±1.85 vs 33.84±2.17) rag/L,P<0.01].Multiple stepwise regression analysis showed that triglycerides and homeostasis assessment for insulin resistance (HOMA-IR) were independent variables of RBP4 (r2 =0.165) in pregnant women.The results suggest that serum RBP4 level is significantly increased in pregnant women.Women with GDM had even higher RBP4 level than that of normal pregnant women,and RBP4 levele was positively correlated with triglycerides and HOMA-IR.     

血清视黄醇结合蛋白4在妊娠糖尿病患者中显著升高

To investigate the relationship between serum retinol-binding protein 4(RBP4) and gestational diabetes mellitus (GDM) in Chinese Han pregnant women.195 (23-42 years) pregnant women were recruited (July 2005 to December 2007) from the Department of Gynecology and Obstetric in Ruijin Hospital during their visiting for routine prenatal examination.99 subjects belonged to GDM group,and 96 belonged to the group with normal glucose tolerance (NGT).65 non-pregnant healthy women served as control.Serum RBP4 was measured using sandwich enzyme linked immunosorbent assay (ELISA).Pregnant women had higher level of serum RBP4 than that of non-pregnant control.The concentration of serum RBP4 was significantly increased in GDM group as compared with NGT group[(43.04±1.85 vs 33.84±2.17) rag/L,P<0.01].Multiple stepwise regression analysis showed that triglycerides and homeostasis assessment for insulin resistance (HOMA-IR) were independent variables of RBP4 (r2 =0.165) in pregnant women.The results suggest that serum RBP4 level is significantly increased in pregnant women.Women with GDM had even higher RBP4 level than that of normal pregnant women,and RBP4 levele was positively correlated with triglycerides and HOMA-IR.     

歌唱训练治疗慢性精神分裂症

目的：探讨歌唱训练在慢性精神分裂症患者康复中的效果。方法：将住院的181例慢性精神分裂症患者随机分为2组，均采用抗精神病药物及一般康复治疗，治疗组90例同时辅以歌唱训练。2组均观察15个月。分别于治疗前及治疗期间每3个月时用住院精神病人社会功能评定量表（SSPI），慢性精神病标准化症状量表（SRCP）和护士用住院病人观察量表（NOSIE)进行评定。结果：治疗后治疗组在SSPI中的残疾等级，SRCP中的总分和阴性症状因子分，NOSEI中的总分，社会能力，社会兴趣，退缩和抑郁因子分均低于对照组（P＜0．05）；治疗组于治疗前后自身对照，3个量表的总分及因子分均低于治疗组前（P＜0．05）；治疗组用药量及病情复发次数均低于对照组（P＜0．01）。结论：歌唱训练对减轻慢性精神分裂症患者残疾程度的阴性症状，提高社会能力及兴趣的效果明显，值得提倡和推广。     

药物的诱变作用和它的DNA的圆二色谱的影响

一个药物若与DNA反应则往往有诱变作用。因此分析药物与DNA的关系是一个重要的课题。已有多种方法,从不同的角度分析药物与DNA之间的相互作用,其中园二色谱(circular dichroism,CD)是一种可靠、灵敏、简便的方法。DNA分子有它特有的CD谱,若药物分子嵌入DNA分子或与之形成复合物,这将改变DNA的构型而导致CD谱的变化。我们试图探索药物的诱变作用和它对DNA的CD谱影响之间的关系。小