脾虚泄泻患者健脾益肾汤临床治疗研究

脾虚泄泻患者健脾益肾汤临床治疗研究福建医学院附属协和医院林谷珍，王小众，王平，杨发端，林峻，陈红绉，林其信，金斌福建省中医药研究院林求诚，叶盈，方素钦本文采用健脾益肾汤，对７６例脾虚泄泻患者进行临床治疗，并观察治疗前后患者临床免疫功能改变及肠粘膜嗜银...     

湖北省农村厕所与粪便处理背景调查及其对策研究

湖北省农村厕所与粪便处理背景调查及其对策研究湖北省爱卫办李传池，张俊超，余伏安湖北省卫生防疫站熊光鑫，孔林汛，郑有清，翁利胜，汪祖陆，曾秀林厕所是人们生活中不可缺少的卫生设施，改厕粪管是关系到农村移风易俗、国计民生、民族素质的一件大事，它既是我国农村...     

Sjoren＇s综合征与抗SSA、抗SSB抗体

Ｓｊｏｒｅｎ＇ｓ综合征与抗ＳＳＡ、抗ＳＳＢ抗体沈阳军区第２０２医院（１１０００３）吕文波，张骏，钱鼎铬，张珠珍，马平，张瑶，吴齐燕，宋丽萍Ｓｊｏｒｅｎ＇ｓ综合征（ＳＳ）是一种临床常见的多发于女性的慢性炎性自身免疫病。分为原发性ＳＳ和继发性ＳＳ。继发性...     

丙帕锗的制备及分析

目的 探索合成条件，制备体内活性和稳定性好的高聚物丙帕锗．并分析其结构确定目的物的正确性。方法 以GeO2为起始原料，磷酸二氢钠为还原剂,制备3-氧锗丙烯酸低分子量聚合物和高分子量3-氧锗丙烯酸(丙帕锗)，并进行元素、红外光谱、核磁共振和X-射线的分析。结果 高分子量聚合物生成，在320℃以下不分解，终产率为72．9％。结论 所采用的方法可行，合成的产品结构正确。     

TDP治疗尘肺124例临床疗效观察

本文报告TDP治疗尘肺124倒临床疗效观察,并与34例羟基喹哌对照治疗临床疗效比较。结果:临床症状好转率在64％～90％之间,与羟基喹哌对照组的50％～89％之间,综合好转率经统计学处理无显著性差异。TDP治疗后石棉肺捻发音消失率65％,X线胸片显示两组病人肺纹理和肺野较疗前变清晰,炎症病变有不同程度的吸收好转。生化指标TDP治疗后铜蓝蛋白,粘蛋白,羟脯氨酸有显著性下降,对照组铜蓝蛋白有显著性下降。免疫指标TDP治疗后IgA有显著性下降,其他指标两组相同。TDP对人体无毒副作用,临床观察表明TDP治疗尘肺确有良好效果。     

BIOEQUIVALENCE BETWEEN rhGH FOR RECONSTITUTION AND READY-TO-USE rhGH IN TWO LIQUID FORMULATIONS

Objective To evaluate the bioequivalence between recombinant human growth hormone （rhGH） for reconstitution, and two dosages of liquid formulation of rhGH [ （151U） 5mg or （301U） lOmg per 3ml ]. Methods The study drugs were tested in a randomized, single-blind and three-period crossover studies in 24 healthy male subjects. The three drugs were administered by subcutaneous injection at a dose of O. 21U/kg body weight. A continuous somatostatin infusion was given in order to suppress the secretion of endogenous GH. The ve- nous blood samples were drawn at different time points to test the serum concentration of GH. The pharmacokinetic parameters were analyzed by statistical methods. Results 90% confidence intervals （CI） of AUC0-24h among three products were all within 80% - 125% interval （ 103. 4% - 116. 5%, 105. 7% - 119. 6% and 91.9% - 103. 7%, respectively）, and the Cls of C,~ among three products were all within 70% - 143% interval （91.9% - 114. 0%, 103. 7% -127. 2% and 81.6% -97. 4%, respectively）. There was no statisitical difference of tmax among all the three products. Conclusion These data demonstrate that there is bioequivalence between rhGH for reconstitution and two liquid formulations of rhGH.