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Humanacellular dermal matrix (HADM) is widely used in the field of burn wound repair and tissue engineering plastic surgery. HADM is manufactored by physical and chemical decellular process to remove the antigenic components that might cause immune rejection in dermis.The extracellular matrix of three-dimensional cell scaffold structure with collagen fibers had been used for wound repair and tissue regeneration, while HADM characterized with low absorption rate after implantation and strong ability to induce angiogenesis in host tissue. Studies reported that after the HADM was implanted into the patient, the host cells, such as fibroblasts and myofibroblasts, as well as lymphocytes, macrophages, granulocytes and mast cells, rapidly infiltrated the graft. The connective tissue and neovascularization were then formed within the HADM three-dimensional cell scaffold, the lymphatic system also appears after vascular reconstruction. Traditional urethral reconstruction using autologous skin flaps has some defects, such as complexity of the technology, risk of necrosis of the skin flaps after transplantation, and failure to achieve functional repair of the urethral epithelium. It has been reported that using HADM to reconstruct the urethra in patients with urethral stricture, hypospadias and bladder-vaginal fistula, showed promising results. Others have reported the experience of using HADM to repair and reconstruct congenital classic bladder exstrophy. HADM has also been used for tissue repair in patients with penile skin defect caused by Fonier’s gangrene and hidradenitis suppurativa, and implanted under Bucks’ fascia to enlarge the penis. The report of HADM implantation for treating premature ejaculation also deserves attention. Researchers found that HADM implantation can form a tissue barrier between the skin and corpus cavernosum, which can effectively reduce penile sensitivity and treat premature ejaculation. The safety and effectiveness of HADM implantation in the treatment of premature ejaculation need to be further standardized by data from multi-center, large-sample clinical studies. In summary, HADM is the extracellular matrix and three-dimensional cell scaffold of human dermis. As a new type of tissue repair material, new blood vessels are formed actively after implantation, which shows good histocompatibility. HADM has shown increasingly broad application prospects in treatment of genitourinary diseases including penis, urethra and bladder diseases. HADM has also been used in the treatment of premature ejaculation in recent clinical studies, and its long-term safety and efficacy need to be further investigated. 相似文献
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目的探讨3%高渗盐水(hypertonic saline,HS)和20%甘露醇(mannitol,MT)治疗小儿脑水肿的临床疗效。方法选择2011年5月—2012年8月入院时格拉斯哥评分为3~7分,均符合小儿急性感染性脑水肿诊断标准的患儿38例,随机分为治疗组和对照组各19例。治疗组采用3%HS以0.5~2 ml.kg-1.h-1的速度持续输入并间歇静脉注射,将血清钠维持在145~155 mmol/L;对照组MT 1~2 g.kg-1.次-1,30 min内静脉注入。两组均每6小时1次,连续使用4次,均通过深静脉注射。比较两组治疗前后颅内压(intracranial pressure,ICP)、平均动脉压(mean artery pressure,MAP)、中心静脉压(central venous pressure,CVP)、血钠、血钾、血浆渗透压、BUN。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后6 h治疗组ICP、MAP、CVP分别为(14.7±4.2)cm H2O(1 cm H2O=0.098 kPa)(79±3)mm Hg(1 cm H2O=0.133 kPa)、(8.4±2.5)cm H2O,对照组分别为(17.3±4.5)cm H2O、(84±4)mm Hg、(8.2±2.3)cm H2O,治疗后两组均可迅速降低ICP,但治疗组作用持续时间比对照组更长,差异有统计学意义(P<0.05)。治疗后两组MAP、CVP比较差异均有统计学意义(均P<0.05)。治疗后6 h治疗组血钠浓度和血浆渗透压均增高[(145.0±4.9)mmol/L、(314.0±23.5)mosm/L],而对照组治疗后血钠及血浆渗透压均明显下降[(131.2±4.3)mmol/L、(276.8±18.6)mOsm/L],两组组间比较差异均有统计学意义(均P<0.05)。两组患儿在观察期内无一例肾功能不全。结论 3%HS可迅速降低ICP,维持MAP,稳定血钠水平和血浆渗透压,持续时间比20%MT更长,可作为小儿脑水肿的一线治疗药物。 相似文献
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[摘要] 目的:探讨西黄浸提液对胃癌SGC-7901 细胞增殖的影响及其可能机制。方法:常规培养胃癌细胞株SGC-7901,用CCK-8 法和细胞流式细胞术检测不同质量浓度(3.2、6.4、12.8 和25.6 mg/ml)的西黄浸提液在不同时间点(24、48 和72 h)对SGC-7901 细胞增殖和凋亡的影响,用qPCR法检测不同质量浓度西黄浸提液对SGC-7901 细胞凋亡相关基因Bax 和Bcl-2 mRNA表达的影响,用Western blotting 检测西黄浸提液对凋亡相关蛋白caspase 3、caspase 9、Bax和Bcl-2 表达的影响。结果:3.2~25.6 mg/ml的西黄浸提液均能有效地抑制胃癌SGC-7901 细胞的增殖(P<0.05 或P<0.01),并且随浓度增加SGC-7901 细胞凋亡率增加(P<0.01)。西黄浸提液能够显著上调SGC-7901 细胞Bax mRNA和下调Bcl-2 mRNA表达水平(P<0.05 或P<0.01),并可增加caspase3、caspase 9 和Bax 蛋白表达、降低Bcl-2 蛋白表达(P<0.05 或P<0.01)。结论:西黄浸提液通过触发细胞凋亡抑制胃癌SGC-7901细胞的增殖,此可成为一个潜在的胃癌辅助治疗的方法。 相似文献
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目的 观察抑白升血糖浆(YBSX)含药血清对白血病HL-60细胞增殖分化的影响。方法 正常大鼠ig给予YBSX后取血制备含药血清。体外传代培养HL-60细胞,观察测定细胞生长情况。通过NBT还原试验、酸性磷酸酶(ACP)和非特异性酯酶(α-NAE)活性测定观察细胞分化情况。利用同位素掺人方法检测细胞内DNA和蛋白质合成速率。结果 YBSX含药血清对第一代HL-60细胞增殖影响不明显;对第二代、第三代细胞生长具有明显抑制作用,细胞增殖率呈进行性下降。YBSX含药血清明显升高HL-60细胞NBT还原率和α-NAE阳性细胞数,增强ACP活性(P〈0.01);降低细胞内^3H-TdR和^3H-Leu掺人量。结论 YBSX可抑制HL-60细胞增殖,诱导其向成熟细胞分化。 相似文献
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