Significance of the Expression of Rho-GDP Dissociation Inhibitorβ,γin Lung Squamous Cell Carcinoma and Adenocarcinoma

Objective:To study the expression of Rho-GDP dissociation inhibitor β,γ(Rho-GDIβ,Rho-GDIγ)in lung squamous cell carcinoma and adenocarcinoma and its relationship with the expression of RhoC(Ras homologus oncogenes C)and clinicopathologic parameters.Methods:Western blot assay was employed for Rho-GDIβ,Rho-GDIγ and RhoC in lung squamous cell carcinoma and adenocarcinoma and non-neoplastic lung tissues of 37 cases with fresh specimens.Results:The study showed that Rho-GDIβ,Rho-GDIγ and RhoC were expressed in lung cancer and non-neoplastic lung tissues,the level in lung cancer tissue was much higher than that in non-neoplastic tissues(P<0.001).In lung cancer,the expression of Rho-GDIβ was much higher in patients with lymph node metastasis(P=0.021),and the expression of Rho-GDIγ was much higher in poorly differentiated tumor than in well-differentiated and moderately differentiated tumor,but both of them were not correlated with other clinicopathologic parameters.The expressions of Rho-GDIβ and Rho-GDIγ were not correlated with the expression of RhoC.Conclusion:In lung cancer,Rho-GDIβ and Rho-GDIγ may play a role in the tumorigenesis,Rho-GDIβ may promote metastasis,and Rho-GDIγ may have some relationship with differentiation.     

CR与DR性能影像特点及其临床应用的比较研究

目的：评价CR与DR成像性能、影像特点及其临床应用并进行比较分析,为临床科学合理应用提供参考。方法：运用CR与DR数字成像基本原理、影像特点及其临床应用技术进行对比分析,评价成像性能、影像特点及其差别。结果：CR与DR成像转换方式各自不同,最终以数字方式输出、成像记录和储存,但CR和DR具有不同的特性及临床应用价值。结论：CR无需改变现有设备且费用较低、使用灵活,DR比CR具有更高空间分辨率、动态范围和DQE、SNR、MTF、更低X线照射量、更快速度,大大改善了工作流程,提高了工作效率,为临床提供更多的选择。     

肺结节病的误诊分析

目的 提高列肺结节病的认|只和诊断符合率：方法 对1990～2001年诊治的6例结节病患者的临床误诊资料进行分析。结果和结论 肺结节病临床表现不典型，胸部X线及CT常表现为肺门增大，以双侧肺门肿大为主，易误诊为肺结核或肿瘤。经纤维支气管镜括检或皮肤粘腆、淋巴结活检可确诊。肺结节病多见青中年成人，女性发病率高，临床症状不典型，在诊断上要结合临床表现、胸片以及纤维支气管镜、皮肤粘膜、淋巴结活检进行病理检查。