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991.
SVT ,includingAVRTandAVNRT ,isakindofarrhythmiaoftenseeninclinicalprac tice .Sotalol,aclassⅢanti arrhythmicdrugwithadditionalβ blockingagentproperties ,hasbeenwidelyusedtotreatvariousarrhythmia(supra ventricularandventricular)efficientlyinwesterncountries[1 9]… 相似文献
992.
76例老年人蛛网膜下腔出血的临床特点 总被引:1,自引:0,他引:1
目的 探讨老年人蛛网膜下腔出血的特点。方法 回顾分析1989年1月-1998年8月收治60岁以上原发性蛛网膜下腔出血76例的临床资料。结果 本组老年蛛网膜下腔出血的临床特点为:(1)头痛发生率低且程度较轻,脑膜刺激征不明显;(2)意识障碍,精神症状明显;(3)消化道出血,ECG明显异常及血糖明显升高等并发症多见。结论 如老年人突然出现眩晕、精神异常或突发颈、臂、腰背疼痛等脊神经刺激征状时,应考虑到 相似文献
993.
目的探讨二尖瓣脱垂(MVP)与急性风湿性心脏炎(ARC)的相关性。方法对108例风湿热并ARC的患者行超声心动图检查以观察MVP的发生率。结果超声心动图检查发现MVP76例,发生率为70%,其中前叶脱垂57例(53%),后叶脱垂13例(12%),前后叶均脱垂6例(6%)。与对照组比较有明显的差异(P<0.01)。ARC所致MVP中74例(97%)并发二尖辫关闭不全(MI),且MVP与MI的严重程度密切相关(P<0.01)。结论ARC是MVP,尤其是二尖瓣前叶脱垂的重要原因之一,而MVP是ARC所致MI的重要因素。 相似文献
994.
995.
目的:探讨冠脉循环中血小板活化状态在冠心病(CHD)发病学中的意义。方法:用放免等方法对受试冠状静脉窦(CS)及升主动脉(AO)血行血小板膜表面α-颗粒膜蛋白(α-GMP-140)和循环内皮细胞(CEC)等测定。结果:CHD患冠脉循环中α-GMP-140含量和CEC浓度均明显升高(P〈0.01),以急心肌梗塞(AMI)组为明显,冠脉狭窄愈严重,二升高愈明显,病灶多发比单发升高明显。结论:CHD患冠脉循环中血小板高度激活,在CHD的发生发展中有一定的意义。 相似文献
996.
卢秀鸾 《天津中医药大学学报》2000,19(2):5-6
甲状腺功能减退症(简称"甲减"),是由于甲状腺激素合成或分泌不足所引起,临床上以畏寒、汗少、动作缓慢、精神萎靡、记忆力减退、肌肉无力、嗜睡、性功能减退等为主要表现的疾病.其症状表现视起病年龄,病程长短以及病情严重程度而有所不同.如功能减退起于胎儿期或出生不久的新生儿,称为呆小症;始于儿童期称为幼年甲状腺功能减退症;始于成年期,称为成年甲状腺功能减退症.病情严重者,可产生粘液性水肿. 相似文献
997.
998.
Xueping Yu Yijuan Zheng Dawu Zeng Yongjun Zhou Jian Sun Milong Su Huatang Zhang Minhui Zheng Zhipeng Huang Wenwu Lin Richeng Mao Jiming Zhang Chunfu Zheng Zhijun Su 《Journal of medical virology》2023,95(1):e28129
CD7 and CD57 are related to the differentiation and functional stages of CD8+ T cells. However, the role of their combined presence in CD8+ T cells in patients with chronic hepatitis B virus (HBV) infection, especially those with end-stage liver disease, remains unclear. Blood samples from healthy volunteers and patients with chronic hepatitis B were analyzed via Luminex assay and ELISA to measure plasma cytokine levels. Further, recombinant IL-22 was used to stimulate peripheral blood mononuclear cells from healthy volunteers, and the frequency of CD3+CD4−CD7+CD57− T cells and apoptosis rates were investigated via flow cytometry. Patients with end-stage liver disease, particularly those with acute to chronic liver failure, showed decreased CD3+CD4−CD7+CD57− T cell frequency. Furthermore, the prevalence of CD3+CD4−CD7+CD57− T cells was negatively correlated with disease severity, prognosis, and complications (ascites). We also observed that IL-22 promoted apoptosis and brought about a decrease in the number of CD3+CD4−CD7+CD57− T cells in a dose-dependent manner. CD3+CD4−CD7+CD57− T cells displayed a B and T lymphocyte attenuator (BTLA)highCD25highCD127high immunosuppressive phenotype and showed low interferon-γ, tumor necrosis factor-α, granzyme A, and perforin expression levels. The present findings will elucidate the pathogenesis of HBV-related end-stage liver disease and aid the identification of novel drug targets. 相似文献
999.
Yi-Fei Zhang Jing-Jing Guo Fan Yang Hang-Yu Zhou Na-Na Zhang Xiao-Chuan Xiong Yue Feng Yong-Qiang Deng Cheng-Feng Qin 《Journal of medical virology》2023,95(1):e28290
The geographic range of Zika virus (ZIKV) has expanded from Asia to the Americas, leading to the 2015–2016 pandemic with enhanced neurovirulence. At present, ZIKV is continuously circulating in many Southeast Asian countries. Unfortunately, the persistent evolution of ZIKV in Southeast Asia and its influence on the biological characteristics of the virus remain incompletely understood. In this study, the in vitro and in vivo properties of a new ZIKV isolate obtained from Cambodia in 2019 (CAM/2019) were characterized and compared with those of the Cambodian strain (CAM/2010). Compared with CAM/2010, the CAM/2019 virus showed similar plaque morphology and growth curves in cell cultures and induced comparable viremia and organ viral loads profiles in both BALB/c and A129 (IFNAR1−/−) mice upon intraperitoneal (i.p.) inoculation. Remarkably, the CAM/2019 virus exhibited enhanced neurovirulence in neonatal mice compared with CAM/2010, with a 74-fold reduction in the 50% lethal dose (LD50). Consistently, CAM/2019 produced higher viral loads in the brains of BALB/c neonatal mice than CAM/2010 did. Sequence alignment showed that the CAM/2019 virus has acquired 12 amino acid substitutions, several of which were found to be associated with neurovirulence. In particular, the CAM/2019 virus shared an A1204T substitution in NS2A with the Thai isolate SI-BKK02 that was isolated from a microcephaly case. Taken together, our results indicate that a ZIKV strain isolated with specific mutations has emerged in Cambodia, highlighting the need for extensive molecular and disease surveillance in Cambodia and other Asian countries. 相似文献
1000.
Clonal analysis of mndne T cells has led to the idenuncation of Z typeS of Th cells, Thl and on. Thl cells,chacterized by secreting interferon-y (Iap-Y), interleukin-2 (IL2) and tumor necrosis factor-5 (TNF-3), involved Principally in cell-mediated ~ity and play acrucial role in defending the host against intracellularPathogens such as a Vallety of yi~es. ThZ cells,secreting IL4, ms, IL-6 and ilo, mostly regulateh~ immune responSe, and may oafs Paxtial PIDtection against extracellula… 相似文献