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Background:In clinical practices, postoperative fracture patients are often treated with analgesics. As one of the alternative therapies for nondrug analgesia, auricular point pressing has advantages of simple operation, easy to use, no injury and adverse reactions, and great potential for development. In this study, the effect of auricular point pressing therapy on postoperative pain of fracture was objectively evaluated through the method of meta-analysis, so as to provide evidence for clinical applications.Methods:PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database were systematically searched and randomized controlled trials on auricular point pressing in the treatment of postoperative pain after fracture were includes. After independent literature screening, data extraction and quality evaluation by 2 researchers, the original data was retrieved, merged, and analyzed. RevMan 5.3 software was adopted for meta-analysisResults:This study could provide high-quality evidence to evaluate the effect of auricular point pressing therapy on postoperative pain of fracture.Conclusion:This systematic review explored whether auricular point pressing therapy is effective on the intervention of postoperative pain after fracture.OSF Registration Number:DOI 10.17605/OSF.IO/AZ4JQ. 相似文献
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Background:Plasminogen activator inhibitor-1 (PAI-1) is considered to be involved in the physiopathological mechanisms of Alzheimer''s disease (AD), metabolic syndrome (MetS), and female infertility. Previous studies investigating the association between PAI-14G/5G (rs1799889) gene polymorphism and the risk of AD, MetS, and female infertility have reported inconsistent results. The aim of the present study was to investigate possible associations.Methods:Eligible studies were retrieved through PubMed, Medline, EMBASE, CNKI, and WANFANG databases. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the associations. Subgroup analyses by ethnicity and mean age, sensitivity analyses, and publication bias were performed.Results:Five studies (four articles) for AD, six studies (six articles) for MetS, and four studies (four articles) for female infertility were included in this meta-analysis. Our results showed no significant associations between the PAI-14G/5G polymorphism and the risk of AD and female infertility in five genetic models. For the risk of MetS, the PAI-1 4G/5G (rs1799889) polymorphism may be associated with the risk of MetS (4G vs 5G, OR = 1.31, 95%CI = 1.04–1.64, P = .021), especially in Asians (4G/4G vs 4G/5G+5G/5G, OR = 1.38, 95%CI = 1.01–1.87, P = .041) and patients with mean age > 50 years old (4G/4G vs 4G/5G+5G/5G, OR = 1.36, 95%CI = 1.03–1.78, P = .029).Conclusion:The present meta-analysis suggested that the PAI-1 4G/5G polymorphism might be associated with the risk of MetS, but no evidence was detected for AD and female infertility. 相似文献
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目的:探讨喘舒片联合布地奈德与沙丁胺醇治疗对支气管哮喘急性发作患儿症状改善、全身炎症反应及肺功能的影响。方法:将2015年8月-2017年9月期间收治的支气管哮喘急性发作患儿100例依据随机数字表法分为对照组和观察组,2组均给予常规对症支持治疗,在此之上,对照组患儿接受布地奈德与沙丁胺醇方案治疗,观察组患儿另外给予喘舒片治疗,均治疗4周。比较治疗前后患儿的日间症状积分、夜间症状积分、炎症指标、肺功能指标水平及药物不良反应发生情况。结果:治疗前2组患儿日间症状积分、夜间症状积分、CRP、TNF-α、IL-6、PEF、FVC及FEV1水平差异无显著性(P>0.05);治疗后,观察组日间症状积分、夜间症状积分、CRP、TNF-α及IL-6水平均显著低于对照组(P<0.05);观察组PEF、FVC及FEV1水平显著高于对照组,差异有显著性(P<0.05);2组药物不良反应发生差异无显著性(χ2=0.154,P=0.695)。结论:喘舒片联合布地奈德与沙丁胺醇治疗支气管哮喘急性发作可有效改善患儿症状和肺功能,减轻全身炎症反应,不良反应少,具有一定临床价值。 相似文献
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Hattie L. Ring Zhe Gao Anirudh Sharma Zonghu Han Charles Lee Kelvin G. M. Brockbank Elizabeth D. Greene Kristi L. Helke Zhen Chen Lia H. Campbell Bradley Weegman Monica Davis Michael Taylor Sebastian Giwa Gregory M. Fahy Brian Wowk Roberto Pagotan John C. Bischof Michael Garwood 《Magnetic resonance in medicine》2020,83(5):1750-1759
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