Influence of growth hormone-insulin-like growth factor Ⅰ axis on normal pregnancy

Objective To investigate the role of growth hormone-insulin-like growth factor Ⅰ (IGF-Ⅰ) axis in normal pregnancy. Methods Totally, 116 normal pregnant women were recruited from January 1997 to June 1998, with 20 normal nonpregnant women as controls. Maternal growth hormone (GH) and IGF-Ⅰ concentrations were assayed by RIA and enzyme-linked immunosorbent assay, respectively. Results Maternal serum levels of GH increased throughout gestation, reached a peak at 25 weeks of pregnancy and remained fairly high (χ[2]=40.458, P<0.0001).There was a significant difference between samples at 5-9 week gestational age and the controls (3.45 μg/L vs 1.61 μg/L, P<0.05). The maternal serum levels of IGF-Ⅰincreased rapidly throughout gestation from 29-week gestation and reached a peak of 188.86 μg/L at term delivery (χ[2]=50.224, P<0.0001). Conclusions Maternal GH levels increased progressively throughout gestation, which correlated with fetal growth. Maternal GH may regulate nutrition supply among mother, placenta and the fetus and play an important role in transporting nutritional substrates by the placenta. The maternal IGF-Ⅰin the third trimester may promote fetal growth and placental functions.     

人工破膜对诊断羊水过少的价值

目的 :探讨人工破膜在诊断羊水过少中的意义。方法 :观察组是根据人工破膜时所流出的羊水量判断羊水多少 ;对照组则用同期产前超声检查所见判断羊水多少。以产时所见羊水量作为最终诊断。结果 :人工破膜和超声诊断羊水过少的符合率分别是 79 73 %和 82 76 % ;两者无显著差异 (P >0 0 5 ) ;人工破膜漏诊率 2 84% ,超声是 6 15 % ,两者无显著差异 (P >0 0 5 )。结论 :人工破膜是诊断本病的一种有价值的方法 ,结合超声检查可作为诊断本病的依据     

梅笠草提取物的抗炎及镇痛作用

[目的 ]探讨梅笠草提取物的抗炎及镇痛作用 .[方法 ]采用巴豆油所致小鼠耳壳肿胀的方法 ,测定耳片的肿胀度 ;用冰醋酸所致小鼠的扭体次数 ,测定小鼠的扭体反应次数 .[结果 ]梅笠草对巴豆油所致小鼠耳壳肿胀有抑制作用 ,与对照组相比有显著性差异 ;同时能减少冰醋酸所致小鼠的扭体次数 ,与对照组相比有显著性差异 .[结论 ]梅笠草提取物具有一定的抗急性炎症和抗镇痛作用     

肋骨肿瘤X线诊断(附50例报告)

目的：探讨肋骨肿瘤的X线诊断。方法：回顾性分析50例经病理证实的肋骨肿瘤的X线表现。结果：肋骨肿瘤基本X线征象是骨破坏,良性肋骨肿瘤呈膨胀性骨破坏,边界清楚,骨皮质完整、变薄。恶生骨肿瘤表现为侵蚀样骨破坏,边界不清,呈虫蚀状,溶骨性一扫光样改变或成骨样改变。结论：肋骨肿瘤可在肺野内形成异常影像,易误诊为肺及纵隔病变,阅胸片时需注意观察,分析肋内改变。     

阴道炎患者HPV6/11-DNA定量分析

目的：了解女性阴道炎患者人乳头瘤病毒6／11型（HPV6／11）的感染情况。方法：荧光定量聚合酶链反应（FQ－PCR）技术检测258例门诊患者阴道分泌物中HPV6／11的病毒拷贝数。结果：共检出HPV6／11阳性者94例,阳性率36．43％,拷贝数在10^5以上者78例,占阳性者中82．98％,40岁以上年龄组阳性率高且病毒复制量均在10^5以上。结论：（1）中老年阴道炎患者就诊晚,感染重。（2）FQ－PCR检测HPV敏感,快速,准确,特别是其定量特点对临床很有意义。     

外伤性白内障人工晶状体植入术临床观察

目的 评价外伤性白内障人工晶体植入的疗效及问题。方法 对56例外伤性白内障人工晶体植入术后进行回顾性研究。结果 术后矫正视力≥0.5者48眼,占85.7%;0.1-0.4者6眼,占10.7%;0.1以下者2眼,占3.6%。结论 利用显微手术方法,使用粘弹剂,控制眼内炎症,选择好手术时机,可使手术效果满意。     

A clinical observation of early short-term use of potent antibiotics in severely burned patients

Objective: To evaluate the effect of early and short-term use of potent antibiotics following extensive severe burn injury. Methods: Seventeen severely burned patients hospitalized in the same period (Nov.,1998 to Oct., 2000) wer esame treatment in Group 2 (n=8) was discontinued until day 15 postburn. The survival rate, blood bacterial culture, body temperature and white blood cell and platelet counts were compared between the 2 groups. Results: All the 17 patients survived and all blood bacterial cultures were negative. No significant difference of body temperature and white blood cell and platelet counts between the 2 groups was observed (P＞0.05). Conclusion: Early use of high-potency antibiotics at short treatment course after extensive severe burn is effective to prevent infection and reduce the cost.     

稀释式自体输血与血液稀释用于乳腺癌根治术的临床观察

目的 观察在乳腺癌根治术中采用稀释式自体输血和急性血液稀释对血液生理的影响。方法 24例乳腺癌根治术病人ASAⅠ-Ⅱ级,随机分为自体输血组（AT）和血液稀释组（HD）。全麻下,AT组采血396－639ml,并输等量6％羟乙基淀粉（HES）注射液,HD组先输入HES 500ml后手术。监测术中失血量、输液量、循环生理指标,检验术前（T1）、血液稀释后输自体血前（T2）及术后1日（T3）的Hb、RBC、Hct、Plt、WBC。结果 AT组T2的HB、RBC、Hct值明显低于HD组（P＜0．05）,而T3明显高于HD组（P＜0．05）。结论 稀释式自体输血能更有效地减少血液流失,保存红细胞。     

桡神经肱肌支的解剖特点与临床意义

目的研究桡神经肱肌支的解剖特点。方法解剖136侧固定尸体的上肢,寻找并分别测量各型肌支的起始点、入肌点、长度、横径及其与桡神经主干的夹角,观察其行程特点。结果桡神经肱肌支的出现率是25.7%(35侧),肱肌支的出现以单侧多见,与性别和侧别无关。根据肱肌支与肱骨长轴的夹角将其分为升支、水平支及降支三种类型。肌支的起点在Hunter's线下1.40cm至Hunter's线上11.70cm,入肌点在Hunter's线上0.60～11.70cm,肌支的长度为0.20～4.68cm,横径是0.4～2.4mm,与桡神经主干的夹角在5～171°。结论桡神经肱肌支的存在较普遍（约1/4）,行上臂、肘部手术时,应对其加以保护。     

孕妇风疹病毒IgG、IgM检测及意义

目的：了解温州地区孕妇对风疹的免疫状态,探讨风疹病毒IgG、IgM检测对评估孕妇免疫状态及判断风疹宫内感染的作用。方法：用ELISA法对1471名产前检查孕妇检测风疹病毒特异性抗体IgG、IgM,电镜检查和分子生物学法检查组织中病毒颗粒和病毒核酸。结果：76.07%（1119／1471）的孕妇具有免疫力,7.41%（109／1471）有孕妇为原发感染,14.14%的孕妇为易感,2.38%（35／1471）的孕妇IgG、IgM均呈阳性,其中1例引产胎儿心肌细胞和1例死胎的心肌、肝及脑细胞中均发现病毒颗粒。结论：同时检测孕妇风疹IgG和IgM可以正确判断孕妇的免疫状态,对IgM阳性孕妇应进行连续多次检测,IgM持续呈阳性三个月以上的孕妇可大致确定为宫内感染。