Clinical and experimental study of xiao er ke cuan ling oral liquid in the treatment of infantile bronchopneumonia]

Xiao Er Ke Chuan Ling Oral Liquid (KCL) is a Chinese herbal preparation consisted of 10 herbs such as Prunus armeniacae, Scutelaria baicalensis, Lonicera japonica etc. 30 children suffering from bronchopneumonia and/or acute bronchitis were treated with KCL (treated group) and another 30 cases were treated with penicillin and aminophylline (control group). Results: cure rate and effective rate in treated group was 26.6%, and 93.3% respectively. While in control group was 30% and 96.6% respectively. No significant differences were seen between them(P > 0.05). The pharmacodynamic experiment showed KCL had potent pharmacological action. The experiment on tracheal fragment of Guinea pig in vitro showed it caused moderately strong smooth muscle relaxation, through inhibition the effect of histamine and acetylcholine. Asthma induction experiment of Guinea pig in vivo showed KCL could significantly prolong the latent period of asthma and alleviate asthmatic symptom. Ammonium water cough induction experiment in mice showed it may apparently prolong cough latent period and reduce times of cough relapse and alleviate cough symptom. KCL had potent antipyretic effect on fever model induced by triple vaccine in rabbits. Bacteriostatic and antiviral experiment in vitro showed the drug had quite strong inhibitory effects for Streptococcus hemolyticus, Staphylococcus aureus, Flexners Dysentery bacillus, Diplococcus pneumoniae and Pseudomonas aeruginosa, and it could potently inhibit the respiratory syncytial virus. KCL is an effective drug in treating bronchopneumonia and acute bronchitis.     

An etiological study on fulminant viral hepatitis]

Viral markers were studied in 79 cases of viral hepatitis with hepatic failure. The results were shown as follows: 8 cases were positive for anti-HAV IgM (10.12%); 76 cases positive for HBsAg or anti-HBc IgM (96.20%) and 41 cases positive for anti-HCV antibodies (51.89%). Among those with anti-HCV positive, 35 cases were co-infected with HBV, 5 cases with HAV and/or HCV, only one was infected with HCV alone 2 cases were HD-Ag positive (2.52%) and one not identified (1.27%). With the reference of clinical findings, patients co-infected with HBV/HCV or anti-HBc IgM positive were more critical and usually entail higher mortality. In cases with HCV co-infections, the positive HBV replication markers seems to be reduced. Hepatic failure without HBV replicative markers had a high rate of hepatic coma as well as poor outcome.     

妇科盆腔肿块超声误诊漏诊原因分析

本文报道经手术病理证实的１６７例妇科盆腔肿块超声检查结果，超声诊断总的符合率为９０．４２％（１５１／１６７）。其中子宫肌瘤、畸胎瘤、卵巢囊肿、卵巢囊腺瘤以及卵巢交响癌符合率较高，对于其它疾病引起的盆腔肿块也有参考价值，本文着重分析误诊漏诊原因，以吸取教训，供超声诊断借鉴。     

子宫颈上皮不典型增生与宫颈癌细胞超微结构的观察比较

光镜和电镜观察慢性宫颈炎上皮不典型增生42例,宫颈癌21例,正常对照7例。上皮不典型增生之一是位于深部的储备细胞增生,细胞的核质比大,细胞器少,分化较低。鳞状上皮不典型增生细胞特点是核质比增大,核形不整,核膜内陷,细胞器增多,桥粒和张力原纤维减少。鳞癌细胞的核质比更大,核膜内褶深,细胞器更多,桥粒和张力原纤维很少或消失,分化低的癌细胞尤明显。粘液性腺癌腺上皮深部可见储备细胞转化的癌细胞。     

不同繁殖材料对半夏产量的影响

实验表明:半夏有性繁殖种子田间出苗率为0～25%,且实生苗当年不能形成商品;无性繁殖则以珠芽和小块茎作种明显优于大块茎。     

胎盘型谷胱甘肽S转移酶mRNA在大鼠肝癌癌前病变组织中的原位表达

应用原位杂交技术，观察了二乙基亚硝胺（ＤＥＮ）诱发大鼠肝癌前病变组织中胎盘型谷胱甘肽Ｓ转移酶（ＧＳＴ－Ｐ）ｍＲＮＡ的表达。结果显示，ＧＳＴ－ＰｍＲＮＡ主要在癌前病变肝组织中的变异灶及灶外卵圆形细胞内表达，且在变异灶间或和同一灶内阳性细胞间表达程度不尽一致，而正常肝、再生肝组织中未见其表达。提示在分子水平上变异灶细胞及卵圆型细胞可能成为实验性肝癌的癌前期细胞     

~(125)碘-绒毛膜促性腺激素的电泳纯化及分析

标记抗原在贮存过程中,由于受幅射分解和脱碘影响而使免疫活性和生物活性降低。我们对自制的~(125)碘-绒毛膜促性腺激素进行了实验观察。结果显示:贮存1月后,其免疫活性和生物活性分别降低了33.1％和44.0％;经电泳纯化后的标记物的免疫活性和生物活性明显提高,分别达到了最初的90.5％和95.3％。     

何杰金氏病增殖细胞核抗原的表达

不同时期的典型何杰金氏病１８例，用抗ＰＣ＿（１０）、Ｌ＿（２６）、ＵＣＨＬ－１抗体作ＳＰ免疫组化染色。结果显示：无一例阴性病例。ＰＣ＿（１０）阳性的ＨＲＳ细胞百分率与传统分类比较有相关性。Ｌ＿（２６）和ＵＣＨＬ＿１阳性细胞的百分率分别为１１．３％～２１．５％和３８．２％～４９．５％。表明不存在单一的Ｂ或Ｔ细胞免疫表达。提示ＨＲＳ细胞与背景中淋巴细胞之间其细胞来源有内在联系。     

游离骨膜移植修复关节软骨缺损的实验研究

在家兔的股骨内髁上作一关节软骨全层缺损,且从同侧胫骨近端取下一片骨膜骨块,将骨膜生发层向外包绕骨块,嵌入缺损处,观察其作用。实验表明,骨膜在一定条件下可以化生成软骨;滑液环境与关节运动在软骨化生过程中起重要作用;透明软骨化生和再生率与运动量及开始时间相关;自体骨可作为一种将游离骨膜固定在软骨缺损内的填充材料。     

不典型脑转移瘤CT和MR的诊断分析

目的：提高CT与MR对不典型脑转移瘤的诊断准确性。方法：回顾性分析58例经临床手术证实的有完整资料的不典型脑转移瘤的CT和MR表现。结果：病变大部分位于幕上，有钙化者较多，约2／3有强化和水肿，且多发。部分有出血和囊变。结论：不典型脑转移瘤的CT和MR表现多种多样，多发者相对容易诊断，单发者诊断不易。颅外肿瘤的检查有助于鉴别诊断。肺部的影像学检查是必不可少的。