Studies of the antagonistic effect of BQ-123 on cerebral vasospasm induced by intracisternal injection of endothelin-1 and subarachnoid hemorrhage

Cerebralvasospasm(CVS)remainsoneofthemajorcausesofseriousoutcomeinpatientswithsubarachnoidhemorrhage(SAH);however,themechanismofwhichisstillnotwellunderstood.Sofaralargenumberofputativespasmogenshavebeenproposedandoneofwhichisendothelins(ETs).ETs,akindofverypotentendogenousvasoconstrictorsubstancesknown[1],hasthreeiso-forms:ET-1,2and3,andET-1isthemostpo-tentvasoconstrictorofthem.lnrecentstudies,ET-lhasbeenproposedasamediatorofCVSfol-lowingSAH[2-4j.TheavailabilityofETantagonistprovided…     

Changes of circulating TNF and its effects on Pseudomonas aeruginosa septic shock in rabbits

Itiswellknownthatcertaincytokinesplayapivotalroleinthedevelopmentoftraumaandshock.Tumornecrosisfactor(TNF)isapolypep-tiedcytokinesynthesizedinmonocytesandmacrophagesinresponsetolipopolysaccharide(LPS)stimulation-TherelationshipbetweenTNFandendotoxic-septicshockbecomesafocusoftheresearchofshockmediators[1'2].Alargeamountofexperimentalandclinicaldata[3-9JsuggestthatTNFplaysanimportantroleinthepathogenesisofendotoxic-septicshockbuttheprecisemechanismandtherelationshipofTNFtoshockseverityrem…     

窥视下尿道内切开术治疗尿道狭窄或闭锁

采用窥视下尿道内切开术治疗尿道狭窄或闭锁５３例，其中４８例治疗成功。狭窄闭锁段≤３ｃｍ者，单纯冷刀切开即可；＞３ｃｍ者，冷刀切开后需加电刀切除疤痕组织，扩大尿道，尿道内皮管植入。３６例患者术后随访１～８年（平均４年６个月），２７例排尿通畅，尿流率和性功能正常。本文就操作要点和并发症防治等进行了详细讨论。     

Glucose microsensor based on electrochemical deposition of iridium and glucose oxidase onto carbon fiber electrodes1

Miniaturized glucose biosensors, prepared by electrochemical deposition of iridium and glucose oxidase (GOx), are characterized. The iridium network offers good retention of GOx and efficient preferential electrocatalytic detection of the liberated hydrogen peroxide at potentials lower than those of common interfering substances (the ascorbic acid signal actually shifts to a higher potential). The remarkable selectivity thus achieved towards the detection of glucose is coupled to a very fast response. Unlike analogous preparations of noble metal carbon fiber biosensors, a two-step electrodeposition process is required for the fabrication of Ir/GOx microelectrodes. The dependence of the biosensor response upon electrodeposition parameters, such as amounts of GOx and iridium or plating time is examined and optimized. Scanning electron microscopy is used to characterized the growth patterns of the iridium and Ir/GOx layers. The high selectivity associated with electrodeposited iridium matrices makes them very attractive for localizing other hydrogen-peroxide-liberating oxidases.     

白细胞介素1α对鼠甲状腺细胞增殖的影响

采用四氮唑蓝（MTT）比色法检测TSH存在和缺乏时白细胞介素1α（IL－1α）对鼠FRTL-5细胞增殖的影响。结果提示，在无TSH条件下IL-1α20～2000kU／L对FRTL－5细胞无明显促增殖作用；在TSH存在时IL－1α20和200kU／L对FRTL－5细胞增殖亦无明显抑制作用，IL－1α2000kU／L则可显著抑制TSH介导的FRTL－5细胞增殖。     

红霉素对犬幽门括约肌压力影响及其与胃动素,生长抑素的关系

为探讨红霉素对犬幽门括约肌的作用及其机理，及其与血浆胃动素，生长抑素的关系。方法采用胃压力测量仪及放射免疫法，同步监测观察了１０条犬静脉滴ＥＭ前后和使用拮抗剂后的幽门压力、血浆ＭＴＬ，ＳＳ的变化，结论：ＥＭ具有增高犬胃幽门压力的作用，其作用机理除与血浆ＭＴＬ有着密切的关系外，血浆ＳＳ也可能共同参与了其调节机制。     

河南省50例并殖吸虫病的流行病学和临床特征

本文对１９８７－１９９５年就诊的５０例并殖吸虫病患者进行了分析，发现近年来本病在河南省有逐渐增多的趋势。患者主要集中在豫西山区及丘陵地带。各年龄组中儿童占６２％，男性多于女性。     

胫骨髁间嵴增生在膝关节退行性变诊断中的临床价值探讨

本研究分３组，典型膝关节退行性变组（简称退变组）５０例，早期膝关节退行性变组（简称早退组）１５例，对照组３０例。分别测量每组Ｘ线片的内、外侧胫骨髁间嵴角与内、外侧嵴高平台比值。经统计学处理，两指标所测值在退变组与对照组及早退组与对照组之间有显著性差异（Ｐ＜０．０５），而退变组与早退组之间则无显著性差异（Ｐ＞０．０５）。结果表明：胫骨髁间嵴硬化变尖不仅是膝关节退行性变的特征性表现之一，而且是其早期Ｘ线征象。     

原发性小肠恶性肿瘤的CT诊断

本文回顾性分析３４例经病理证实的原发性小肠恶性肿瘤的ＣＴ表现。病变包括腺癌１６例，平滑肌肉瘤１２例，淋巴瘤６例。ＣＴ扫描能明确肿瘤向腔内和腔外侵犯的程度，清晰显示肿瘤与邻近结构的关系，有无局部及远处转移等，为临床治疗提供帮助。鉴别诊断应包括小肠良性肿瘤、炎性病变和转移性肿瘤等。