全文获取类型
收费全文 | 111229篇 |
免费 | 10294篇 |
国内免费 | 6540篇 |
专业分类
耳鼻咽喉 | 884篇 |
儿科学 | 1520篇 |
妇产科学 | 1400篇 |
基础医学 | 13047篇 |
口腔科学 | 1949篇 |
临床医学 | 13421篇 |
内科学 | 15437篇 |
皮肤病学 | 1265篇 |
神经病学 | 4684篇 |
特种医学 | 4251篇 |
外国民族医学 | 37篇 |
外科学 | 11257篇 |
综合类 | 20525篇 |
现状与发展 | 33篇 |
一般理论 | 16篇 |
预防医学 | 8570篇 |
眼科学 | 2581篇 |
药学 | 12519篇 |
112篇 | |
中国医学 | 6646篇 |
肿瘤学 | 7909篇 |
出版年
2024年 | 324篇 |
2023年 | 1410篇 |
2022年 | 3653篇 |
2021年 | 4942篇 |
2020年 | 3786篇 |
2019年 | 3171篇 |
2018年 | 3405篇 |
2017年 | 3226篇 |
2016年 | 3086篇 |
2015年 | 4416篇 |
2014年 | 5615篇 |
2013年 | 5887篇 |
2012年 | 8301篇 |
2011年 | 8923篇 |
2010年 | 6417篇 |
2009年 | 5344篇 |
2008年 | 6397篇 |
2007年 | 6510篇 |
2006年 | 6037篇 |
2005年 | 5297篇 |
2004年 | 4613篇 |
2003年 | 4477篇 |
2002年 | 4012篇 |
2001年 | 3194篇 |
2000年 | 2608篇 |
1999年 | 2093篇 |
1998年 | 1168篇 |
1997年 | 1173篇 |
1996年 | 945篇 |
1995年 | 802篇 |
1994年 | 692篇 |
1993年 | 460篇 |
1992年 | 671篇 |
1991年 | 558篇 |
1990年 | 504篇 |
1989年 | 475篇 |
1988年 | 382篇 |
1987年 | 348篇 |
1986年 | 290篇 |
1985年 | 220篇 |
1984年 | 197篇 |
1983年 | 144篇 |
1982年 | 140篇 |
1981年 | 136篇 |
1980年 | 112篇 |
1979年 | 151篇 |
1978年 | 120篇 |
1977年 | 134篇 |
1976年 | 118篇 |
1970年 | 96篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Vanaporn Wuthiekanun Varunee Desakorn Gumphol Wongsuvan Premjit Amornchai Allen C. Cheng Bina Maharjan Direk Limmathurotsakul Wirongrong Chierakul Nicholas J. White Nicholas P. J. Day Sharon J. Peacock 《Clinical and Vaccine Immunology : CVI》2005,12(4):555-556
An immunofluorescent (IF) method that detects Burkholderia pseudomallei in clinical specimens within 10 min was devised. The results of this rapid method and those of an existing IF method were prospectively compared with the culture results for 776 specimens from patients with suspected melioidosis. The sensitivities of both IF tests were 66%, and the specificities were 99.5 and 99.4%, respectively. 相似文献
92.
93.
目的 探讨老年人急性阑尾炎的临床特点,更好地把握腹腔镜阑尾切除(LA)术的方法和特点。方法 回顾分析50例老年人急性阑尾炎LA的临床资料。结果 LA均获成功,患者全部治愈,无严重的并发症发生,肠功能恢复时间及住院时间均缩短。结论 老年人反应迟钝,阑尾炎进展快,易发生坏疽及穿孔,合并症多,手术风险较高,LA是安全、可行的,除个别腹膜后阑尾炎外,其余均可施行LA。 相似文献
94.
目的观察比较泼尼松联用硫唑嘌呤和大剂量静脉用免疫球蛋白(IVIG)对扩张型心肌病(DCM)患儿心功能及预后的影响。方法将DCM患儿20例分为治疗Ⅰ和Ⅱ组,分别在传统抗心衰治疗基础上加泼尼松联用硫唑嘌呤和大剂量IVIG,治疗1个疗程后评价心功能,检测治疗前后左房横径(LA)、左室舒张期内径(LV)、左室射血分数(LVEF)、心脏指数(CI),并计算其治疗前后变化。所有病例随访1年,计算1年存活率。结果治疗Ⅱ组心功能明显优于治疗Ⅰ组(P均<0.05);两组LA、LV、LVEF和CI治疗后较治疗前均有明显改善(P均<0.05);治疗Ⅰ组各参数变化明显低于治疗Ⅱ组(P均<0.05),其1年存活率明显低于治疗组Ⅱ(P<0.05)。结论泼尼松联用硫唑嘌呤和大剂量IVIG均能改善DCM患儿心功能,但IVIG疗效优于泼尼松联用硫唑嘌呤。 相似文献
95.
Hiroko Utsunomiya Wanninayake M. Tilakaratne Kazufumi Oshiro Satoshi Maruyama Makoto Suzuki Hiroko Ida-Yonemochi Jun Cheng Takashi Saku 《Journal of oral pathology & medicine》2005,34(8):498-507
BACKGROUND: Oral submucous fibrosis (OSF) is a chewing habit-related pre-cancerous condition of the oral mucosa affecting predominantly south Asians. It is histopathologically characterized by epithelial atrophy and fibrosis of the subepithelial connective tissue. Fibrosis extends all the way into the muscle layer, leading to difficulty in mouth opening. However, the dynamics of extracellular matrix (ECM) remodeling with OSF progression is largely unknown. METHODS: Forty biopsy specimens of OSF and 10 of normal buccal mucosa were examined for expression/deposition modes of eight ECM molecules by histochemistry, immunohistochemistry, and in situ hybridization. RESULTS: In the early stage of OSF, tenascin, perlecan, fibronectin, collagen type III were characteristically enhanced in the lamina propria and the submucosal layer. In the intermediate stage, the ECM molecules mentioned above and elastin were extensively and irregularly deposited around muscle fibers. In the advanced stage, such ECM depositions decreased and were entirely replaced with collagen type I only. Their gene expression levels varied with progression of fibrosis, but the mRNA signals were confirmed in fibroblasts in the submucosal fibrotic areas. CONCLUSIONS: The results indicate that the ECM remodeling steps in OSF are similar to each phase of usual granulation tissue formation. Restricted mouth opening may be a result of loss of variety of ECM molecules including elastin into the homogeneity of collagen type I replacing muscle fibers. 相似文献
96.
Systemic anticancer therapy for hepatocellular carcinoma (HCC) is limited by intrinsic drug resistance and accompanying liver
dysfunction. However, recent advances in molecular targeted therapy (MTT) have shed light on the treatment of advanced HCC.
A recent randomized, placebo-controlled trial demonstrated that sorafenib, a multi-target tyrosine kinase inhibitor, prolonged
overall survival and time-to-progression in patients with advanced HCC. This breakthrough highlights the potential of MTT
targeting hepatocarcinogenic pathways, such as the Raf/MAPK/ERK pathway, angiogenic pathways and the EGFR signaling pathway.
This review discusses the current status and the potential of developing novel MTTs for advanced HCC. 相似文献
97.
根管治疗术远期疗效的影响因素 总被引:6,自引:1,他引:5
根管治疗术(root canal therapy,RCT)是治疗牙髓病、根尖周病的主要方法.影响根管治疗术远期疗效的因素较多,而RCT前根尖周状态和根充位置是两大主要因素. 相似文献
98.
99.
Although many monoclonal antibodies have been made in human colon cancer, none of them are from the Chinese species. Recently, a colon cancer cell line CC-M2 established from a Chinese patient has been completely characterized and used as immunogen to produce monoclonal antibodies. Monoclonal antibodies were produced by standard hybridoma technique. The fusion rate was 95.8%. An isotype IgG1 of high proliferation named as Sam-2 was used in this study. The titers were measured around 10(4). Further studies on MoAb Sam-2 through indirect immunofluorescent and immunoperoxidase tests revealed its good specificity and sensitivity in colorectal cancer tissue. In CEA study, the result indicated that Sam-2 may react on a non-CEA related antigen. For further clinical application, the antigen was identified as a glycoprotein by chemical resistant test. In preliminary studies using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting techniques, Sam-2 could recognize two closed antigens or a dimer antigen with molecular weight 25.2 and 27 Kd respectively. 相似文献
100.
应用鸡卵清蛋白致敏和刺激小鼠复制过敏性气道炎症反应模型研究血小板激活因子选择性拮抗剂YM-264对抗原引起气道嗜酸性粒细胞(EOS)浸润的影响。结果发现,正常小鼠支气管肺泡灌洗液(BALF)中未见到EOS;致敏小鼠给予抗原多次反复吸入刺激后,BALF中EOS急剧增多。在YM-264治疗各组中,YM-264的不同剂量分别导致EOS数下降27.0%、48.2%及67.9%。还发现YM-264抑制EOS对气道的浸润伴随着白细胞介素(IL)-5水平的明显下降。提示YM-264通过抑制IL-5的产生从而抑制了EOS在气道的聚集。 相似文献