大气细颗粒物诱导IL-17A表达增强香烟暴露小鼠气道炎症反应的机制

目的 探讨大气细颗粒物(PM)增强香烟暴露小鼠炎症反应的机制.方法 用野生型(WT)及IL-17A基因敲除(IL-17A-/-)小鼠,按随机数字表法随机分为对照组、熏烟组、PM组、熏烟+PM组,每组6～8只.采用香烟烟雾暴露装置烟熏,气道滴注方法吸入PM,观察气道炎症反应,连续干预3个月后取检.用HE检测肺组织炎症浸润...     

Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes

We aimed to determine the utility of biopsy data and anemia for the prediction of renal outcomes in Chinese patients with type 2 diabetes. In total, 441 Chinese patients with type 2 diabetes and biopsy-confirmed diabetic nephropathy (DN) were enrolled in a retrospective study. Their renal pathology was assessed using the Renal Pathology Society system. Cox proportional hazards models were used to estimate hazard ratios (HRs) for end-stage renal disease (ESRD), and immunofluorescence staining was used to assess the expression of hypoxia-inducible factor (HIF)-α in patients’ kidneys. We found that glomerular pathology classification was an independent pathological predictor of low hemoglobin concentration, according to linear and logistic regression analyses. Each 1 g/dL decrease in baseline hemoglobin concentration was associated with a 42% higher risk of an adverse renal outcome, after adjustment for clinical and pathologic covariates. In patients with severe glomerular lesions, the risk of progression to ESRD was significantly higher if mild or moderate/severe anemia was present, but in patients with mild glomerular lesions, the risk was only significantly higher in those with moderate or severe anemia than in the absence of anemia. Harrell’s C Concordance was improved, but the Akaike information criterion was worsened by adding the glomerular pathology classification to the use of anemia status and clinical data. Immunofluorescence staining revealed that renal HIF-1α and HIF-2α expression was significantly higher in classes II–IV than class I. Thus, the addition of glomerular pathology classification increases the value of anemia status for the prediction of the progression to ESRD.     

广西壮族自治区多地区长寿人群分布特征及其相关因素研究

目的:探索我国典型长寿地区人群中与健康长寿的相关因素,为老年人群的健康长寿提供有价值的参考数据。方法:采用登记和入户问卷调查方法收集和解析广西壮族自治区桂林市永福县、河池市巴马县和防城港市东兴市长寿老人（≥90岁）的人口学基本特征;然后在当地一般人群中,随机选取年龄组对照（40~85岁）。分别对比长寿和对照人群的性别、...     

Severe radiation thyroiditis after radioactive iodine for treatment of Graves’ disease

Radiation thyroiditis resulting from radioactive iodine-131 treatment for Graves’ disease is an uncommon complication. Although a majority of patients are asymptomatic or manifest mild symptoms that can be managed conservatively, published literature describing severe radiation thyroiditis resulting in significant morbidity is lacking. We herein report on six patients with severe radiation thyroiditis that resulted in hospitalisation, including an unusual complication of myopericarditis.     

Effectiveness of traditional Chinese medicine music therapy on anxiety and depression emotions of lung cancer patients: A protocol for systematic review and meta-analysis

Background:Lung cancer patients often accompanied with severe depression and anxiety emotions, and those negative emotions could affects the treatment and recovery of the illness, decrease the patients’ quality of life. In recent years, traditional Chinese medicine five-element music therapy (TCM-FEMT) is widely used for psychological problems of lung cancer patients for its unique advantages, TCM-FEMT applied to negative emotions management of lung cancer patients has been reported in many publications, but there is lacks evidence-based medicine, in this study, effectiveness of TCM-FEMT on anxiety and depression emotions of lung cancer patients will be systematically evaluated.Methods:PubMed, the Cochrane Library, Web of Science, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, WanFang Database were electronically searched to collect RCTs on the efficacy of TCM-FEMT on anxiety and depression emotions of lung cancer patients from inception to February 2021. In addition, retrospect the references of the included literature to supplement the relevant literature. Research selection, data extraction and quality evaluation of literature will be carried out by 2 researchers, respectively. RevMan 5.3 software will be used for statistical analysis.Results:This study will comprehensively summarize the current trials to determine the effectiveness of TCM-FEMT on anxiety and depression emotions of lung cancer patients.Conclusion:This study will provide comprehensive evidence for the efficacy of TCM-FEMT on anxiety and depression emotions of lung cancer patients.     

Practical aspects of electrophoretic deposition to produce commercially viable supercapacitor energy storage electrodes

Electrophoretic deposition (EPD) is a highly convenient and demonstrated industrial operation for the manufacture of surface coatings. Recent years are seeing increasing evidence in using this technique to produce energy storage electrodes (notably for lithium-ion batteries, solid-state devices, supercapacitors, and flow batteries), but their advancement for industrialisation remains unclear. Using activated carbon (AC) as an exemplary supercapacitor material, this study reports the practical aspects of porous energy storage electrodes produced by the EPD technique. Practical electrodes with commercially viable parameters are shown, specifically high density active material (in excess of 9.8 mg cm⁻²) and very thick coating layer (about 168 μm). Research investigations including colloidal electrolyte formulations, electrode deposition parameters and cell performance testing are reported. Materials and electrode properties were studied by various charactersisation tools. Prototype A7 sized pouch cells were assembled and tested to show evidence of practical EPD electrodes in a commercial cell format. Electrochemical performance of EPD over slurry casting is presented. In short, this research shows the successful production of practical EPD electrodes for electrochemical energy storage, which is directly relevant for scale-up industrial adoption and can be applied as a platform electrode manufacturing technology for any battery and supercapacitor materials.

Electrophoretic deposition (EPD) is a highly convenient and demonstrated industrial operation for coatings manufacture. It is now suitable for the production of practical energy storage electrodes for batteries, capacitors & solid-state devices.     

Two-step preparation of Keggin-PW12@UIO-66 composite showing high-activity and long-life conversion of soybean oil into biodiesel

A polyoxometalate acid can be encapsulated into a metal–organic framework to construct a novel kind of solid-acid catalyst. In this work, the two-step method —high-temperature preparation of Zr₆O₄(OH)₄(CH₃COO)₁₂ and low-temperature self-assembly—has been adopted to synthesize the PW₁₂@UIO-66 composite (PW₁₂ = H₃PW₁₂O₄₀; UIO-66 = Zr₆O₄(OH)₄(OOC–C₆H₄–COO)₁₂). The as-synthesized PW₁₂@UIO-66 composite exhibits highly crystalline, good octahedron morphology, large specific surface area (1960 m² g⁻¹) and high thermal stability (>500 °C), which clearly demonstrates the potential as a solid-acid catalyst. Additionally, the PW₁₂@UIO-66 composite may be accomplished with 85% utilization of H₃PW₁₂O₄₀ and 95% yield through this synthetic procedure. The performances of the PW₁₂@UIO-66 composite are investigated by catalyzing the simultaneous transesterification and esterification of soybean oil into biodiesel. Under the optimal conditions, the conversion of the soybean oil into biodiesel would exceed 90% over the as-synthesized PW₁₂@UIO-66 composite. As the crucial indexes for industrial prospects, the recycling and life experiments were surveyed. After 10 times recycling and 4 weeks, the structure and performance of the PW₁₂@UIO-66 composite remained unchanged and in the meantime the PW₁₂@UIO-66 composite still maintained a high activity to convert soybean oil into biodiesel.

A Keggin-PW₁₂@UIO-66 composite has been synthesized solvothermally through a two-step process and employed as a solid acid catalyst to convert soybean oil into biodiesel.     

Realizing high performance flexible supercapacitors by electrode modification

It is well known that the structure of an electrode material seriously affects its electrochemical performance. In this study, we prepare hybrid structured NiCo₂S₄@PPy nanoarchitectures by a hydrothermal method and subsequent electrodeposition process. The specific capacitance of the obtained sample is 1733.23 C g⁻¹ at 1 A g⁻¹. The assembled asymmetric device presents an energy density of 59.59 W h kg⁻¹ at 1404.04 W kg⁻¹. The excellent electrochemical performance can be attributed to the synergistic effect between the high theoretical specific capacitance of the NiCo₂S₄ sheets and the superior cycling stability of the PPy film. The device also shows an outstanding mechanical flexibility at different bending angles.

We prepare hybrid structured NiCo₂S₄@PPy nanoarchitectures by a hydrothermal method and subsequent electrodeposition process. The assembled asymmetric device presents an energy density of 59.59 W h kg⁻¹ at 1404.04 W kg⁻¹.     

Designing conductive networks of hybrid carbon enables stable and long-lifespan cotton-fiber-based lithium–sulfur batteries

In modern society, flexible rechargeable batteries have become a burgeoning apodictic choice for wearable devices. Conventional lithium–sulfur batteries lack sufficient flexibility because their electrode materials are too rigid to bend. Along with the inherent high theoretical capacity of sulfur, lithium–sulfur batteries have some issues, such as dissolution and shuttle effect of polysulfides, which restricts their efficiency and practicability. Here, a flexible and “dead-weight”-free lithium–sulfur battery substrate with a three-dimensional structure was prepared by a simple strategy. With the cooperative assistance of carbon nanotubes and graphene attached to cotton fibers, the lithium–sulfur battery with 2.0 mg cm⁻² sulfur provided a high initial discharge capacity of 1098.7 mA h g⁻¹ at 1C, and the decay rate after 300 cycles was only 0.046% per cycle. The initial discharge capacity at 2C was 872.4 mA h g⁻¹ and the capacity was maintained 734.4 mA h g⁻¹ after 200 cycles with only a 0.079% per cycle decay rate.

A flexible, “dead weight”-free lithium–sulfur battery substrate was prepared, and batteries using these substrates showed great electrochemical performance.