Investigation on the Evolution of Nano-Scale Defects of CL-20 Crystals under Thermal Treatment by Wide/Small-Angle X-ray Scattering

Nano-scale crystal defects extremely affect the security and reliability of the explosive charges of weapons. In order to understand the evolution of nano-scale defects of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane (CL-20) explosive crystals under thermal treatments, the specific surface, volume fraction and size distribution of the nano-scale defects were studied by using Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS) during the temperature range from 30 °C to 200 °C. The results showed that the number and size of the pores in CL-20 powder did not change significantly during the heating process before phase transformation (30–160 °C). At 170 °C, CL-20 began to convert from ε- to γ- phase, and the specific surface and volume fraction of the nano-scale defects increased significantly. Further investigation of the pore size distribution showed that the number of pores with a small size (radius 9–21 nm) changed particularly significantly, resulting from the cracking of the CL-20 crystal powder during phase transition. At 200 °C, the phase transition was completed and γ-CL-20 was created, and the small-sized pores gradually grew into medium-sized (radius 21–52 nm) pores over time when the temperature was fixed at 200 °C.     

儿童过敏性结膜炎诊治进展

在针对过敏性疾病的诊治中,儿童过敏性结膜炎越来越受到关注,但大量的漏诊和误诊存在.本文就儿童过敏性结膜炎的解剖特点、发病机制、临床症状和体征、诊断以及治疗进行综述.     

Prognostic and incremental value of computed tomography-based radiomics from tumor and nodal regions in esophageal squamous cell carcinoma

Objective: This study aimed to evaluate the prognostic value of preoperative radiomics and establish an integrated model for esophageal squamous cell cancer(ESCC).Methods: A total of 931 patients were retrospectively enrolled in this study(training cohort, n=624; validation cohort, n=307). Radiomics features were obtained by contrast-enhanced computed tomography(CT) before esophagectomy. A radiomics index was set based on features of tumor and reginal lymph nodes by using the least absolute shri...     

优化美罗培南治疗老年脓毒血症的临床分析

目的 分析血药浓度监测(TDM)优化美罗培南治疗老年脓毒血症的临床疗效。方法 选择2021年1月至2022年2月我院收治的脓毒血症老年患者64例,随机分为对照组31例,观察组33例。对照组接受常规美罗培南治疗,观察组接受TDM优化美罗培南,对比治疗1周后两组病情变化、生化指标、肺功能、实验室指标与不良反应等。结果 治疗1周后,观察组APACHEⅡ评分/SOFA评分低于对照组(P<0.05),观察组肌酐、胆红素、AST、ALT、EVLW、PVPI下降(P<0.05),观察组白细胞、降钙素原、C-反应蛋白水平低于对照组(P<0.05),观察组美罗培南药物谷浓度与峰浓度高于对照组(P<0.05),观察组PK/PD参数最低抑菌浓度(MIC)为1、2、4时血清药物浓度高于MIC的时间(%T>MIC)优于对照组(P<0.05)。结论 65岁以上老年脓毒血症患者,实施TDM优化美罗培南治疗,可降低病情严重水平,调控机体生化指标、炎症指标,提高药物抗菌活性、药物有效浓度,改善患者肺功能,减少药物不良反应,具有临床意义。     

Ancillary ligand effects on α-olefin polymerization catalyzed by zirconium metallocene: a computational study

The polymerization of α-olefins catalyzed by zirconium metallocene catalyst was systematically studied through experiments and density functional theory (DFT) calculations. Having achieved an agreement between theory and experiment, it was found that the effect of the catalyst ligand on the C C insertion reaction was significantly greater than that on the β-H elimination reaction. Therefore, the molecular weight of polymers can be increased by improving the activity of the C C insertion. In addition, in comparison with propylene, the chain length of α-olefins can directly affect the stereotacticity of polymerization products, owing to steric hindrance between the polymer chain and monomer.

The polymerization of α-olefins catalyzed by zirconium metallocene catalyst was systematically studied through experiments and density functional theory (DFT) calculations.     

语音播报提醒功能对早期药物临床试验中采血时间的影响

目的 探讨语音播报提醒功能对早期药物临床试验中采血时间准确性的影响。方法 自Sample Guide智能样本管理系统数据库中调取2018年6月—2019年10月无语音播报提醒功能条件下6 558个血液样本采集时间作为对照组;2019年12月—2021年2月启用语音播报提醒功能后12 768个血液样本采集时间作为试验组。比较两组实际采血时间与计划采血时间的偏离程度、采血时间超窗发生率、采血时间记录异常发生率。结果 启用语音播报提醒功能后,实际采血时间与计划采血时间的偏离程度较小,差值绝对值比较差异有统计学意义（P<0.05）;采血时间超窗发生率明显降低,差异有统计学意义（P<0.05）;采血时间记录异常的发生率明显降低,差异有统计学意义（P<0.05）。结论 语音播报提醒功能可以缩短实际采血时间与计划时间的偏离程度,有效减少药物临床试验中采血时间超窗次数的发生,提高了早期药物临床试验中采血时间的准确度。     

人体运动姿态的校正对改良五禽戏增加骨效应的研究探讨

目的观察人体运动姿态的校正对改良五禽戏增加骨效应的影响。方法 "五禽戏"是由后汉著名的医学家华佗在"流水不腐户枢不蠹"的思想指导下,总结前人健身活动经验,模仿虎、鹿、熊、猿、鹤等兽禽动作编创而成,用以活动筋骨,增强体质,是中华民族一种古老的健身体操。改良五禽戏是浙江中医药大学体育部在传统五禽戏的基础上进行简化、改编而成,分为虎举、虎扑、鹿转、鹿抵、熊攀、熊晃、猿摘、猿蹲、鸟翔和鸟展十个动作,用于日常体育课程教学。改良五禽戏继承了传统五禽戏的健身原理,对一些难度较大的动作进行简化和改良,更适合广大中老年人练习。多积极参加运动可以适度提升骨量,改善身体状况,需要锻炼的中老年人往往会出现条件限制使锻炼时间减少、运动姿势不标准达不到预期的效果甚至不合适的运动对身体不利。本文探讨运动姿态的校正系统应用于改良五禽戏动作的校正,在原理、技术、设备等方面论证其可行性及意义。结果该系统原理充分、技术可靠、设备齐全,可以使改良五禽戏动作更加标准化,更大程度地增加骨效应。结论人体运动姿态的校正对改良五禽戏增加骨效应有着良好的促进作用,切实可行,值得付诸实践。     

龙江韩氏妇科诊治子宫内膜异位症经验

龙江韩氏妇科流派是全国首批64家中医流派传承建设单位,至今已历时180年之久,现已五世相传,具有深远学术影响,在诊治子宫内膜异位症上具有丰富临床经验,韩氏主张子宫内膜异位症的发病以肝脏功能失调为主,与脾、肾密切相关,病变累及气、血、痰、湿、瘀互结,阻滞经脉,最终导致“离经之瘀血”内阻冲任、胞宫,留滞日久而渐成癥瘕积聚。韩氏认为子宫内膜异位症属于中医痛经、癥瘕、不孕、月经不调等多种妇科病症的综合表现,由于潜伏期较长,一般明确诊断较晚,多以痛经、月经不调、不孕前来就诊。多年以来,韩氏临证主要运用中医理论,结合临床经验与现代检查方法,“病症结合”,从整体和局部出发,采用疏肝活血祛瘀止痛法,创立“内异止痛汤”,同时针对不同个体辨证施治加减运用。