晚期扁桃体癌术后缺损修复与功能重建

目的探讨晚期扁桃体癌切除术后缺损修复与功能重建的组织瓣供区选择。方法 2000年10月-2010年2月收治13例晚期扁桃体癌患者。男11例,女2例;年龄39～67岁,平均53.6岁。高分化鳞状细胞癌5例,中分化鳞状细胞癌8例。按国际抗癌联盟(UICC)1997年口咽癌的分期标准:T1N1M0 1例,T2N1M0 2例,T2N2M0 2例,T3N1M0 3例,T3N2M0 2例,T4N1M0 2例,T4N2M0 1例。病程1～8个月,平均4.3个月。肿瘤侵及鼻咽侧壁1例、下咽侧壁3例、会厌1例、软腭4例、舌根部3例。肿瘤浸润范围2 cm×2 cm～12 cm×6 cm。患者均采取手术加术后补充放疗的综合治疗措施。经颈-颌-扁桃体联合入路切除肿瘤后,5例采用带蒂胸大肌皮瓣、5例采用游离前臂皮瓣、3例采用游离股前外侧皮瓣一期修复。结果术后病理报告示颈淋巴结转移10例;补充放疗后8个月～2年局部复发2例,颈部淋巴结转移3例。术后1例带蒂胸大肌皮瓣修复术后第5天出现颈部感染,1例游离前臂皮瓣修复术后12 h出现血管危象,均经对症处理后治愈;其余组织瓣均顺利成活,切口Ⅰ期愈合。1例股前外侧皮瓣供区切口裂开,二期缝合。患者均获随访,随访时间1～6年,平均3.6年。5例带蒂胸大肌皮瓣修复者,术后均有不同程度吞咽梗阻感及闭塞性鼻音,言语清晰度较差。8例游离皮瓣修复者术后外观、吞咽及发声功能较满意,供区无功能障碍。患者术后咬关系均恢复正常,面部外形和功能基本正常。按直接计算法,3年生存率为60.0%(6/10),5年生存率为37.5%(3/8)。结论对晚期扁桃体癌术后缺损的修复应首选游离前臂皮瓣及股前外侧皮瓣,但对于组织需要量大和术前放疗失败的患者,宜选用带蒂胸大肌皮瓣修复。     

高效液相色谱法测定小青龙颗粒中甘草酸铵含量

目的建立小青龙颗粒中甘草酸铵的含量测定方法。方法采用高效液相色谱法,色谱柱为Alltima C18柱(150 mm×4.6 mm,5μm),流动相为水-乙腈-冰醋酸(65∶35∶2.5),流速1.0 mL/min,柱温为室温,检测波长为254 nm。结果甘草酸铵质量浓度在15.2～114.1μg/mL之间与峰面积呈良好线性关系,r=1.0。平均加样回收率为96.40%,RSD=1.67%。结论该方法简便易行,结果准确可靠。     

Neutrophil-to-lymphocyte and hypopharyngeal cancer prognosis: System review and meta-analysis

Several studies have reported the value of neutrophil-to-lymphocyte ratio (NLR) for the prognosis of hypopharyngeal cancer. However, contradictory findings have also been published. We aimed to clarify the effect of NLR on the prognosis of hypopharyngeal cancer through meta-analysis. Systematic search of PubMed and other database with study selection and data extraction. The combined hazard ratio (HR) and 95% confidence intervals (CI) were calculated using STATA, applying either a fixed-effects or random-effects model. Meta-regression, subgroup analysis, and sensitivity analysis were used to analyze sources of heterogeneity. Publication bias were also assessed. This meta-analysis included 2232 patients with hypopharyngeal cancer from seven studies. The combined HR (OS, HR = 1.80, 95CI%, 1.14–2.82; PFS, HR = 1.88, 95CI%, 1.26–2.79) suggested that high NLR was associated with poor overall survival (OS) and progression-free survival (PFS). Pretreatment NLR can be used as an effective serological indicator to assess the prognosis of patients with hypopharyngeal cancer.     

张国海应用谷精草合剂异病同治儿科疾病

结合多发性抽搐症、过敏性鼻炎、急性支气管炎等临床验案,介绍张国海运用谷精草合剂异病同治病机属火与风、热与风或火、热、风等夹杂合而为病的儿科疾病的经验.