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51.
Yusen Chen Jun Nakura Jing-Ji Jin Zhihong Wu Miyuki Yamamoto Michiko Abe Yasuharu Tabara Yoshikuni Yamamoto Michiya Igase Xiao Bo Katsuhiko Kohara Tetsuro Miki 《Hypertension research》2003,26(6):439-444
The beta-adrenoceptor (beta-AR)-stimulatory guanine nucleotide-binding (Gs) protein system has been shown to play important roles in the cardiovascular system. The gene encoding the alpha-subunit of Gs proteins (GNAS1) is a candidate genetic determinant for hypertension. Because alcohol consumption is known to affect blood pressure partly through the beta-AR-Gs protein system, we examined the possible interaction between GNAS1 T393C polymorphism and drinking status in the association with hypertension in the present study. As a result, a non-significant but reasonable trend supporting the presence of an interaction was shown (p = 0.076). In line with this trend, the T393C polymorphism significantly interacted with drinking status in the association with systolic blood pressure (p = 0.028). Moreover, supporting the presence of an interaction, T allele carriers consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than CC homozygotes in non-drinkers and light drinkers. In contrast, CC homozygotes consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than T allele carriers in moderate to heavy drinkers. The present study also showed a significant interaction between the T393C polymorphism and drinking status in the association with pulse pressure (p = 0.026), reflected by a significant association between the T393C polymorphism and pulse pressure in moderate to heavy drinkers (p = 0.026). These findings may be helpful in conducting further molecular and biological studies on the relationship among the effects of alcohol, the beta-AR-Gs protein system, and hypertension. 相似文献
52.
53.
Jianhua Yan Zhongyao Wu Eye Hospital Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou China 《眼科学报》2003,19(3):174-175
Purpose:To report a rare sign, paracentral corneal dellen that developed in a middleaged female patient with Graves ophthalmopathy.Methods:A paracentral corneal dellen developed in the left eye in a 42-year-old woman who was diagnosed as Graves ophthalmopathy. The patient had remarkable upper eyelid retraction, upper eyelid lag and upward motility restriction. The Graves ophthalmopathy was classified as Grade Ⅳ according to NOSPECS classification.Results:Local artificial tear film and 0.3% Tobramycin eye drops were administered to both eyes.Twenty-four hours later, the left corneal dellen disappeared.Conclusions:Graves ophthalmopathy can lead to paracentral corneal dellen because of severe upper eyelid retraction and upward motility restriction of the eye in spite of the lack of lagophthalmos. Artificial tear drop and antibiotic eye drop therapy helped even though the patient did not have corneal exposure. Eye Science 2003;19:174-175. 相似文献
54.
多种底物在免疫金银染色检测抗核抗体试验中的联合应用 总被引:2,自引:0,他引:2
将多种底物联合应用于免疫金银染色检测ANA试验,与各底物单独应用比较,可明显改善检测的敏感性与核型显示。其中,两种鼠脏器印片联合应用的结果可与Hep-2细胞的结果相当,三种及四种鼠脏器印片联合应用的结果可与Hep-2细胞和一种鼠脏器印片联合应用的结果相当,且均不使正常人ANA阳性率明显升高。 相似文献
55.
T.-N. Wu Chen-Yang Shen Saou-Hsing Liou Guang-Yang Yang K.-N. Ko Show-Lin Chao Chao-Chun Hsu P.-Y. Chang 《International archives of occupational and environmental health》1997,69(6):386-391
To monitor the lead hazards in industries and to investigate the prevalence of elevated blood lead levels (BLLs) in lead-exposed
workers, a lead surveillance system (PRESS-BLLs) has been established and operated in Taiwan, Republic of China, since July
1993. A cohort of lead-exposed workers who received a periodic annual health examination at 55 accredited hospital laboratories
was constructed. A total of 9807 separate BLL measurements were reported to the system in 1994. The mean BLL was 15.8 μg/dl
in male workers and 11.6 μg/dl in female workers. The mean BLL of lead-exposed workers was significantly (P<0.05, z-test) higher than that of the general Taiwanese population (8.6 μg/dl for males and 6.7 μg/dl for females). In addition,
the BLLs of 983 (10.0%) workers exceeded the regulatory action level (40 μg/dl for males; 30 μg/dl for females). The workplaces
and homes of 57% of the workers with elevated BLLs were thoroughly investigated to determine the sources of lead contamination.
These actions identified the causes of elevated BLLs and set up strategies to reduce workers’ lead exposure. The establishment
of this occupational lead surveillance system represents a method for monitoring of lead hazards from occupational and environmental
settings to prevent lead poisoning. The information acquired from the system can help in the setting up of a priority of prevention
and the development of control measures. It is also useful for further monitoring of changes in the BLLs of the lead-exposed-worker
cohort. The Health Department of Taiwan can use this information to evaluate the effectiveness of current industrial hygiene
practice. Subjects with elevated BLLs have been medically treated and placed on long-term follow-up for sequelae.
Received: 2 September 1996/Accepted: 29 November 1996 相似文献
56.
57.
大鼠脊髓缺血再灌流时脊髓神经元对躯体和内脏传入刺激的反应 总被引:1,自引:0,他引:1
50只大鼠用乌拉坦麻醉,箭毒制动。通过阻断腹主动脉血流以模拟腰段脊髓的局部缺血和再灌流损伤,玻璃微电极记录L2节段脊髓单位放电(SCUDs),观察缺血再灌流时脊髓神经元对腓神经刺激(PNV),内脏大神经刺激(VLNV)及两者同时刺激(SV)的反应。结果在缺血前所记录的133个自发放电单位中,对3种刺激均产生兴奋(E)、抑制(I)及无反应(NR)3种形式的反应,表明大鼠L2节段脊髓存在躯体、内脏和躯体内脏反应性神经元,并有会聚和阻塞现象。在脊髓缺血再灌流时,神经元对PNV、VLNV、SV也产生E、I、NR3种形式的反应,提示脊髓缺血再灌流时神经元对躯体和内脏传入刺激的反应形式不受影响;但缺血时SCUDs对PNV、VLNV产生反应的单位数减少,这表明脊髓缺血损伤时神经元对躯体和内脏传入刺激的反应性减弱,随着缺血损伤加重,脊髓神经元对躯体内脏信号的整合功能下降 相似文献
58.
.OH生成液0.05ml.100g^-1经胶静脉注入心脏,可使麻醉大鼠的左心室收缩压力、左心室压力与心率乘积、左心室压力上升最大速率和左心室压力下降最大速率明显下降。 相似文献
59.
外周血及移植肾内嗜酸性粒细胞变化的临床意义 总被引:2,自引:0,他引:2
为了解移植肾在急性排斥时外周血和移植肾内嗜酸性粒细胞(EO)变化的意义,动态观察31例同种异体肾脏移植病人的外周血和移植肾内EO的变化。结果发现在急性排斥反应时,移植肾内EO数>2%者占80.9%,明显高于肾功能稳定时,P<0.01;重度排斥中血EO数>4%者占82.6%,明显高于肾功能稳定时和中度以下排斥者,P<0.01。结果认为,测定移植肾内的EO变化可以做为监测急性排斥反应的可靠指标,外周血中的EO明显增多常提示排斥反应较为严重。 相似文献
60.
Bloodflowvariationandenergymetabolisminthegastricmucosafollowing7.5%hypertonicsalineresuscitationWangJunyi(王俊义);WuGuosheng;(吴... 相似文献