全文获取类型
收费全文 | 1412695篇 |
免费 | 113311篇 |
国内免费 | 3335篇 |
专业分类
耳鼻咽喉 | 18420篇 |
儿科学 | 46605篇 |
妇产科学 | 41077篇 |
基础医学 | 200984篇 |
口腔科学 | 37777篇 |
临床医学 | 126171篇 |
内科学 | 284667篇 |
皮肤病学 | 33362篇 |
神经病学 | 117056篇 |
特种医学 | 53874篇 |
外国民族医学 | 464篇 |
外科学 | 210780篇 |
综合类 | 32785篇 |
现状与发展 | 3篇 |
一般理论 | 487篇 |
预防医学 | 110135篇 |
眼科学 | 31512篇 |
药学 | 98577篇 |
1篇 | |
中国医学 | 3357篇 |
肿瘤学 | 81247篇 |
出版年
2021年 | 10875篇 |
2019年 | 11693篇 |
2018年 | 16622篇 |
2017年 | 12696篇 |
2016年 | 14285篇 |
2015年 | 16040篇 |
2014年 | 22616篇 |
2013年 | 33461篇 |
2012年 | 45468篇 |
2011年 | 48020篇 |
2010年 | 28206篇 |
2009年 | 27115篇 |
2008年 | 44386篇 |
2007年 | 46883篇 |
2006年 | 47458篇 |
2005年 | 45915篇 |
2004年 | 43804篇 |
2003年 | 41752篇 |
2002年 | 40250篇 |
2001年 | 73036篇 |
2000年 | 74577篇 |
1999年 | 61589篇 |
1998年 | 17004篇 |
1997年 | 15443篇 |
1996年 | 15603篇 |
1995年 | 14807篇 |
1994年 | 13405篇 |
1993年 | 12595篇 |
1992年 | 45856篇 |
1991年 | 43516篇 |
1990年 | 41516篇 |
1989年 | 39566篇 |
1988年 | 36196篇 |
1987年 | 35374篇 |
1986年 | 32881篇 |
1985年 | 31295篇 |
1984年 | 23836篇 |
1983年 | 20036篇 |
1982年 | 12220篇 |
1981年 | 10789篇 |
1979年 | 20719篇 |
1978年 | 14586篇 |
1977年 | 12094篇 |
1976年 | 11380篇 |
1975年 | 11629篇 |
1974年 | 14001篇 |
1973年 | 13547篇 |
1972年 | 12654篇 |
1971年 | 11483篇 |
1970年 | 10925篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
93.
M. D. Wiles A. El-Nayal G. Elton M. Malaj J. Winterbottom C. Gillies I. K. Moppett K. Bauchmuller 《Anaesthesia》2022,77(2):143-152
Pulse oximetry is used widely to titrate oxygen therapy and for triage in patients who are critically ill. However, there are concerns regarding the accuracy of pulse oximetry in patients with COVID-19 pneumonitis and in patients who have a greater degree of skin pigmentation. We aimed to determine the impact of patient ethnicity on the accuracy of peripheral pulse oximetry in patients who were critically ill with COVID-19 pneumonitis by conducting a retrospective observational study comparing paired measurements of arterial oxygen saturation measured by co-oximetry on arterial blood gas analysis (SaO2) and the corresponding peripheral oxygenation saturation measured by pulse oximetry (SpO2). Bias was calculated as the mean difference between SaO2 and SpO2 measurements and limits of agreement were calculated as bias ±1.96 SD. Data from 194 patients (135 White ethnic origin, 34 Asian ethnic origin, 19 Black ethnic origin and 6 other ethnic origin) were analysed consisting of 6216 paired SaO2 and SpO2 measurements. Bias (limits of agreement) between SaO2 and SpO2 measurements was 0.05% (−2.21–2.30). Patient ethnicity did not alter this to a clinically significant degree: 0.28% (1.79–2.35), −0.33% (−2.47–2.35) and −0.75% (−3.47–1.97) for patients of White, Asian and Black ethnic origin, respectively. In patients with COVID-19 pneumonitis, SpO2 measurements showed a level of agreement with SaO2 values that was in line with previous work, and this was not affected by patient ethnicity. 相似文献
94.
95.
Marta López-Fauqued Laura Campora Frédérique Delannois Mohamed El Idrissi Lidia Oostvogels Ferdinandus J. De Looze Javier Diez-Domingo Thomas C. Heineman Himal Lal Janet E. McElhaney Shelly A. McNeil Wilfred Yeo Fernanda Tavares-Da-Silva 《Vaccine》2019,37(18):2482-2493
Background
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.Methods
Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses were performed on the pooled total vaccinated cohort, consisting of participants receiving at least one dose of RZV or placebo. Solicited and unsolicited adverse events (AEs) were collected for 7 and 30?days after each vaccination, respectively. Serious AEs (SAEs) were collected from the first vaccination until 12?months post-last dose. Fatal AEs, vaccination-related SAEs, and potential immune-mediated diseases (pIMDs) were collected during the entire study period.Results
Safety was evaluated in 14,645 RZV and 14,660 placebo recipients. More RZV than placebo recipients reported unsolicited AEs (50.5% versus 32.0%); the difference was driven by transient injection site and solicited systemic reactions that were generally seen in the first week post-vaccination. The occurrence of overall SAEs (RZV: 10.1%; Placebo: 10.4%), fatal AEs (RZV: 4.3%; Placebo: 4.6%), and pIMDs (RZV: 1.2%; Placebo: 1.4%) was balanced between groups. The occurrence of possible exacerbations of pIMDs was rare and similar between groups. Overall, except for the expected local and systemic symptoms, the safety results were comparable between the RZV and Placebo groups irrespective of participant age, gender, or race.Conclusions
No safety concerns arose, supporting the favorable benefit-risk profile of RZV. 相似文献96.
C. M. de Bont N. Eerden W. C. Boelens G. J. M. Pruijn 《Clinical and experimental immunology》2020,199(1):1-8
Neutrophils can form neutrophil extracellular traps (NETs) to capture microbes and facilitate their clearance. NETs consist of decondensed chromatin decorated with anti-microbial proteins. Here, we describe the effect of neutrophil proteases on the protein content of NETs. We show that the neutrophil serine proteases degrade several neutrophil proteins associated with NETs. Interestingly, the anti-bacterial proteins associated with NETs, such as myeloperoxidase, calgranulin B and neutrophil elastase (NE), seem to be less susceptible to proteolytic degradation than other NET proteins, such as actin and MNDA. NETs have been proposed to play a role in autoimmune reactions. Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases. In conclusion, neutrophil serine proteases have a major impact on the NET proteome and the proteolytic changes of NET-associated proteins may counteract autoimmune reactions to NET components. 相似文献
97.
Toidi Adekambi Chris C. Ibegbu Stephanie Cagle Ameeta S. Kalokhe Yun F. Wang Yijuan Hu Cheryl L. Day Susan M. Ray Jyothi Rengarajan 《The Journal of clinical investigation》2015,125(5):1827-1838
BACKGROUND. The identification and treatment of individuals with tuberculosis (TB) is a global public health priority. Accurate diagnosis of pulmonary active TB (ATB) disease remains challenging and relies on extensive medical evaluation and detection of Mycobacterium tuberculosis (Mtb) in the patient’s sputum. Further, the response to treatment is monitored by sputum culture conversion, which takes several weeks for results. Here, we sought to identify blood-based host biomarkers associated with ATB and hypothesized that immune activation markers on Mtb-specific CD4+ T cells would be associated with Mtb load in vivo and could thus provide a gauge of Mtb infection.METHODS. Using polychromatic flow cytometry, we evaluated the expression of immune activation markers on Mtb-specific CD4+ T cells from individuals with asymptomatic latent Mtb infection (LTBI) and ATB as well as from ATB patients undergoing anti-TB treatment.RESULTS. Frequencies of Mtb-specific IFN-γ+CD4+ T cells that expressed immune activation markers CD38 and HLA-DR as well as intracellular proliferation marker Ki-67 were substantially higher in subjects with ATB compared with those with LTBI. These markers accurately classified ATB and LTBI status, with cutoff values of 18%, 60%, and 5% for CD38+IFN-γ+, HLA-DR+IFN-γ+, and Ki-67+IFN-γ+, respectively, with 100% specificity and greater than 96% sensitivity. These markers also distinguished individuals with untreated ATB from those who had successfully completed anti-TB treatment and correlated with decreasing mycobacterial loads during treatment.CONCLUSION. We have identified host blood-based biomarkers on Mtb-specific CD4+ T cells that discriminate between ATB and LTBI and provide a set of tools for monitoring treatment response and cure.TRIAL REGISTRATION. Registration is not required for observational studies.FUNDING. This study was funded by Emory University, the NIH, and the Yerkes National Primate Center. 相似文献
98.
C. Lindsay DeVane 《Pharmacotherapy》2016,36(9):953-954
99.