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911.
Objective. To undertake the pilot experiments of prevention of disability (POD) in 14 different geographical areas to serve as examples for future development of rehabilitation work in China and in Asia. Mahods. According to the principles mid national criterion, 27 000 people affected by leprosy were selected and assessed using disability record forms at beginning and followed up regularly for observing changes of different indica-tors. Results. A total of 197 neuritis cases were detected and treated with prednisolone out of 1 407 new or active cas-es. Serf-care training of eyes, hands and feet were conducted for 10 500 disabled people affected by leprosy. Compre-hensive therapy was given to 1 804 cases having comphcated ulcers of which 1 055 cases have got their ulcers healed. Out of 706 prostheses, 613 were given to patients with satisfactory results. Surgical treatment was given to 269 cases and 251 have shown good progress. Conclusion. Most of patients have got benefit from the project in function or appearance which is very helpful for their going back to the society and agreed by foreign experts during the final evaluation. The experiences from the pro-ject can be implemented in the whole country. 相似文献
912.
佛山市致乏库蚊对3种杀虫剂的抗性监测 总被引:1,自引:0,他引:1
目的:了解佛山市优势蚊种致乏库蚊对溴氰菊酯、氯菊酯、马拉硫磷3种常用杀虫剂的抗性水平,为科学、合理使用药物提供依据。方法:浸渍法。结果:致乏库蚊对溴氰菊酯、氯菊酯、马拉硫磷的LC_(50)分别为0.000537mg/L、0.03439mg/L和0.156mg/L,与其敏感品系对这三种杀虫剂的LC_(50)比较,前者是后者的2.8倍、6.1倍和2.1倍。结论:这3种药物对致乏库蚊均未引起明显的抗药性。但应注意合理使用药物,延缓抗性的进一步发展。 相似文献
913.
PF方案化放治疗晚期鼻咽癌的远期疗效 总被引:29,自引:0,他引:29
目的探索用PDD/5-Fu方案化放治疗晚期鼻咽癌的疗效。方法1989年12月~1990年12月间,选择76例Ⅲ、Ⅳ期鼻咽癌患者,先作3周期PDD(20mg(m2)-1d-1,iv,第1~5天)和5-Fu[700mg(m2)-1d-1,连续静脉滴注,第1~5天]诱导化疗,随后尽快作放疗,此为综合治疗组。以1989年作单纯放疗的86例晚期鼻咽癌患者作对照组。两组放疗方法、时间/剂量分割均相同。结果化疗有效率为89.3%,完全缓解率为18.4%。综合治疗组(综合组)总的5年生存率为48.7%,对照组为33.7%(P>0.05)。综合组T2N3和T2~4N3患者的5年生存率为44.1%和39.5%,均明显高于对照组的21.6%及20.4%(P<0.05)。结论PF方案化放治疗提高了T2~4N3患者的5年生存率。 相似文献
914.
915.
陵水暗罗活性成分研究 总被引:8,自引:0,他引:8
从陵水暗罗(polyalthia nemoralis A.etDC)根的乙醇提取物中分离得到五个化合物。经光谱(UV,IR,1H-NMR,13C-NMR,DEPT和MS)解析和化学反应,分别鉴定为暗罗素(zincpolyanemine,PN1),2-巯基吡啶-N-氧化物铜盐(PN2),β-谷甾醇(PN3),β-谷甾醇-β-D-吡喃葡萄糖甙(PN4)和2-巯基吡啶-N-氧化物-2-S-β-D-吡喃葡萄糖甙(PN5),其中PN5为新化合物,PN2为新天然产物。PN1和PN2有较强抗疟、防霉杀菌作用。PN5的抗疟、防霉试验尚在进行中。 相似文献
916.
SEARCHFORHERPESSIMPLEXVIRUSTYPE2(HSV-2)ANDHUMANPAPILLOMAVIRUS(HPV)INTHENORMALANDABNORMALCERVICALSAMPLESZhangWei;张伟;JinShunqia... 相似文献
917.
The relationship of scapulothoracic motion to glenohumeral motion, commonly referred to as the scapulohumeral rhythm, has been the subject of numerous investigations. The purpose of this study was to assess the effects of localized muscular fatigue on three-dimensional scapulothoracic motion and the resulting scapulohumeral rhythm during elevation of the humerus in the plane of the scapula. A six-degree-of-freedom digitizing system (Metrecom(TM)) was used to define scapular and trunk reference frames, and three-dimensional Eulerian angles were determined for scapular motion for 0-135 degrees of humeral elevation before and after fatigue of the upper and lower trapezius muscles. Local muscle fatigue was determined using spectral analysis of electromyographic signals for the upper and lower trapezius muscles. The results demonstrated an average of 22% decrease in the median frequencies of the muscles sampled following resistive exercise, suggesting a state of local muscle fatigue. Concomitant with the fatigue was a selective decrease in scapulothoracic motion about two of the three scapular axes. RELEVANCE: Occupational and recreational conditions often require repetitive overhead elevations of the arms, resulting in muscular fatigue and various pathologies. During repetitive arm elevations the scapulohumeral rhythm or synchronization between the humerus and the scapula is balanced to allow the most efficient elevation of the arm. A better understanding of this much-discussed scapulohumeral rhythm and the changes induced by muscular fatigue may provide insight into the pathomechanics associated with shoulder dysfunction. 相似文献
918.
Boddy Alexander W. Snikeris Fred C. Kringle Robert O. Wei Greg C. G. Oppermann James A. Midha K. K. 《Pharmaceutical research》1995,12(12):1865-1868
Purpose. Highly variable drugs pose a problem in bioequivalence assessment because they often fail to meet current regulatory acceptance criteria for average bioequivalence (80–125%). This paper examines alternative approaches to establishing bioequivalence.
Methods. Suggested solutions have included alternate study designs, e.g., replicate and multiple dose studies, reducing the level of the confidence interval, and widening the acceptance limits. We focus on the latter approach.
Results. A rationale is presented for defining wider acceptance limits for highly variable drugs. Two previously described methods are evaluated, and a new method having more desirable properties is proposed.
Conclusions. We challenge the one size fits all current definition of bioequivalence acceptance limits for highly variable drugs, proposing alternative limits or goal posts which vary in accordance with the intrasubject variability of the reference product. 相似文献
919.
Crystals of the C2-acetate analog of paclitaxel, grown from a mixture of isopropyl alcohol and methanol, belong to the space group P2l with a = 9.058(3), b = 18.306(5), c = 15.043(1) , = 97.09(1)°, Z = 2, V = 2475.1(9)3, D
calc = 1.269 gcm–3 and µ = 0.75 cm–1. The structure was determined by direct methods and refined to R(F) = 0.054 and wR(F) = 0.057 for 605 variables and 3496 observed reflections. The paclitaxel side chain possesses a conformation similar to that observed in the crystal structure of docetaxel (Taxotere®). A three dimensional network of hydrogen bonds is formed through solvent molecules and stabilizes the crystal lattice. 相似文献
920.
1998年,上海市普陀区医疗保险办公室改革公费医疗支付方式,对门诊项目实行按人头付费。本文就改革实施一年来公费医疗费用发生情况作一分析,对按人头付费方式实施效果进行评估,得出以下结论:该支付方式较为有效地降低了医疗费用的增长幅度,减少了浪费;对促进医院加强内部管理,转变经营策略,重视医疗成本控制,提高卫生资源的利用效率起到了积极的作用。同时提出,要注意纠正个别医疗机构控制费用方法简单化的偏差,要考虑人群年龄结构因素对医疗费用的影响,适当调整付费标准,以避免医疗机构在承担费用支出方面出现畸轻畸重的问题。 相似文献