全文获取类型
收费全文 | 1671篇 |
免费 | 84篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 47篇 |
妇产科学 | 54篇 |
基础医学 | 224篇 |
口腔科学 | 55篇 |
临床医学 | 118篇 |
内科学 | 402篇 |
皮肤病学 | 64篇 |
神经病学 | 137篇 |
特种医学 | 53篇 |
外科学 | 121篇 |
综合类 | 4篇 |
预防医学 | 168篇 |
眼科学 | 48篇 |
药学 | 121篇 |
中国医学 | 9篇 |
肿瘤学 | 128篇 |
出版年
2023年 | 5篇 |
2022年 | 30篇 |
2021年 | 56篇 |
2020年 | 38篇 |
2019年 | 54篇 |
2018年 | 62篇 |
2017年 | 35篇 |
2016年 | 44篇 |
2015年 | 64篇 |
2014年 | 61篇 |
2013年 | 98篇 |
2012年 | 145篇 |
2011年 | 153篇 |
2010年 | 94篇 |
2009年 | 69篇 |
2008年 | 106篇 |
2007年 | 84篇 |
2006年 | 86篇 |
2005年 | 93篇 |
2004年 | 84篇 |
2003年 | 68篇 |
2002年 | 71篇 |
2001年 | 8篇 |
2000年 | 7篇 |
1999年 | 10篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 13篇 |
1995年 | 15篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 2篇 |
1989年 | 8篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1980年 | 2篇 |
1979年 | 3篇 |
排序方式: 共有1761条查询结果,搜索用时 15 毫秒
31.
Lazzarini LC de Fatima do Amparo Teixeira M Souza Rodrigues R Marcos Nunes Valiante P 《Respiration; international review of thoracic diseases》2008,76(3):356-360
Necrotizing sarcoid granulomatosis (NSG) is a rare entity mainly characterized by a prominent granulomatous vasculitis affecting middle-aged or old individuals and with a favorable prognosis. Although many believe it is a variant of sarcoidosis, the proper classification is still a matter of debate as some of its features are found in sarcoidosis but also in Churg-Strauss syndrome, Wegener's disease and hypersensitivity pneumonitis. In this paper, we described for the first time a case of NSG in a family with several cases of sarcoidosis, reinforcing the relationship between NSG and sarcoidosis. Additional interesting findings were the young age of the patient (15 years old), the symptoms limited to the respiratory tract (uncommon when NSG affects youngsters) and the increase in serologic markers of autoimmune disease. Though complete criteria for autoimmune disease were not present, systemic lupus erythematosus and Sjogren's syndrome are possible candidates. As sarcoidosis is described to be associated with several autoimmune diseases, this finding is an additional suggestion of the relationship between both entities. 相似文献
32.
Dr. José V. Roig M.D. Carlos Villoslada M.D. Salvador Lledó M.D. Amparo Solana M.D. Elvira Buch M.D. Rafael Alós M.D. Joaquín Hinojosa M.D. 《Diseases of the colon and rectum》1995,38(9):952-958
PURPOSE: A prospective study was made of the prevalence and associations of pudendal neuropathy in 96 patients with fecal incontinence (72 females and 24 males). METHODS: Clinical exploration, perineal level measurement, anorectal manometry, and electrophysiologic evaluations (pudendal nerve terminal motor latency (PNTML) and external sphincter fiber density (FD)) were performed. RESULTS: Pudendal neuropathy (defined as PNTML>2.2 ms or FD>1.65) was found in 67 patients (69.8 percent) and was more common in females (75 percent) than in males (50 percent;P
= 0.05). Pudendal neuropathy was also more frequent in patients with pathologic perineal descent (85 percent
vs.
55 percent;P
<0.01) or exhibiting risk factors such as difficult labor or excessive defecatory straining (P
<0.01). Perineal level at straining correlated inversely with both PNTML and FD (P
<0.01). Manometric findings suggested greater external anal sphincter damage in patients with pudendal neuropathy than in those suffering fecal incontinence but no neuropathy (P
<0.05). Pressure caused by the striated anal sphincter was also inversely correlated to PNTML. Pudendal neuropathy was encountered in 37 of 63 (58.7 percent) patients with sphincter injury
vs.in 31 of 33 (93.9 percent) patients with idiopathic fecal incontinence (P
< 0.01). CONCLUSIONS: Pudendal neuropathy is an etiologic or associated factor often present in patients with fecal incontinence. In this sense, clinical, perineometric, and manometric findings correlate with pudendal neuropathy, though such explorations do not suffice to detect it.Read at the meeting of The American Society of Colon and Rectal Surgeons, Orlando, Florida, May 8 to 13, 1994. 相似文献
33.
Tatiane Calve Douglas Vicente Russo Júnior Ana Maria Forti Barela 《Revista brasileira de fisioterapia (S?o Carlos (S?o Paulo, Brazil))》2018,22(1):64-69
Background
Exercises that could prevent gait impairment of older adults should be implemented in such a way that practitioners can keep motivation and adherence independent of older adults fitness levels.Objective
This study describes how younger and older adults use a non-pedal tricycle to transport their bodies along a pathway.Methods
Nine younger (24 ± 4.9 y) and nine older (66 ± 4.0 y) adults participated in this study. They moved along a straight pathway at a self-selected comfortable speed with reflective markers on their main lower limb landmarks. A computerized gait analysis system with infrared cameras was used to obtain kinematic data to calculate spatial-temporal parameters and lower limb angles.Results
Overall, participants from both groups were able to perform the task moving at a similar mean speed, with similar stride length and ankle joint excursion. Older adults had higher cadence (mean difference of 17 steps/min; 95% CI = 0.99–1.15) and hip excursion (mean difference of 12°; 95% CI = 28–33), longer stance duration (mean difference of 3.4%; 95% CI = 56.2–59.5), and lower knee excursion (mean difference of 6°; 95% CI = 47.9–53.8) than younger adults.Conclusion
Older adults were able to transport their body with a non-pedal tricycle with more hip and less knee excursion than younger adults. Professionals that work with the older population should look at and take into consideration the use of non-pedal tricycles in exercise protocols and investigate the long-term impacts. 相似文献34.
35.
Laize Peron Tófolo Tatiane Aparecida da Silva Ribeiro Ananda Malta Rosiane Aparecida Miranda Rodrigo Mello Gomes Júlio Cezar de Oliveira Latifa Abdennebi-Najar Douglas Lopes de Almeida Amanda Bianchi Trombini Claudinéia Conationi da Silva Franco Audrei Pavanello Gabriel Sergio Fabricio Wilson Rinaldi Luiz Felipe Barella Paulo Cezar de Freitas Mathias Kesia Palma-Rigo 《European journal of nutrition》2015,54(8):1353-1362
36.
Fábio Teixeira Kuhn Fabíola Trevizol Verônica Tironi Dias Raquel Cristine Silva Barcelos Camila Simonetti Pase Karine Roversi Caren Tatiane de David Antoniazzi Katiane Roversi Nardeli Boufleur Dalila Moter Benvegnú Tatiana Emanuelli Marilise Escobar Bürger 《Toxicology letters》2015
Chronic consumption of processed food causes structural changes in membrane phospholipids, affecting brain neurotransmission. Here we evaluated noxious influences of dietary fats over two generations of rats on amphetamine (AMPH)-conditioned place preference (CPP). Female rats received soybean oil (SO, rich in n-6 fatty acids (FA)), fish oil (FO, rich in n-3 FA) and hydrogenated vegetable fat (HVF, rich in trans fatty acids (TFA)) for two successive generations. Male pups from the 2nd generation were maintained on the same supplementation until 41 days of age, when they were conditioned with AMPH in CPP. While the FO group showed higher incorporation of n-3 polyunsaturated-FA (PUFA) in cortex/hippocampus, the HVF group showed TFA incorporation in these same brain areas. The SO and HVF groups showed AMPH-preference and anxiety-like symptoms during abstinence. Higher levels of protein carbonyl (PC) and lower levels of non-protein thiols (NPSH) were observed in cortex/hippocampus of the HVF group, indicating antioxidant defense system impairment. In contrast, the FO group showed no drug-preference and lower PC levels in cortex. Cortical PC was positively correlated with n-6/n-3 PUFA ratio, locomotion and anxiety-like behavior, and hippocampal PC was positively correlated with AMPH-preference, reinforcing connections between oxidative damage and AMPH-induced preference/abstinence behaviors. As brain incorporation of trans and n-6 PUFA modifies its physiological functions, it may facilitate drug addiction. 相似文献
37.
Renata Couto Gustavo Couto Ingrid Abrahão Inaê Compagnoni Tatiane Carnio Julio Tolentino 《Revista portuguesa de cardiologia》2021,40(4):305.e1-305.e3
Trichosporon beigelii is a non‐pathogenic fungus that can however become an opportunist agent of disseminating and potentially fatal infections, especially in immunocompromised patients. In the literature, there are only 11 published cases of infective endocarditis due to T. beigelii. Most of these cases involved immunocompetent individuals and the main risk factor was the presence of a prosthetic valve. The longest interval between surgery and endocarditis was eight years. In the present study, a case of prosthetic valve endocarditis due to T. beigelii is reported in an immunocompetent patient 11 years after mitral valve replacement. As with similar cases, low clinical suspicion and negative blood cultures delayed the beginning of antifungal therapy and cardiac surgery. Considering the high mortality and severity of T. beigelii endocarditis, it should be considered when there is a prosthetic valve infection with negative blood cultures, irrespective of the time elapsed since the previous surgery. 相似文献
38.
39.
Pérez-Ceballos E Corral J Alberca I Vayá A Llamas P Montes R González-Conejero R Vicente V 《British journal of haematology》2002,118(2):610-614
The prothrombin G20210A polymorphism, which correlates with the plasmatic prothombin levels, is the second genetic risk factor for deep venous thrombosis (DVT), although its prothrombotic role is mild. Recently, the prothrombin A19911G polymorphism, also associated with slight variations of the prothrombin level, has been suggested to modulate the thrombotic risk of the G20210A polymorphism in a preliminary study including few patients and controls. Our study evaluated the effect of the A19911G polymorphism in the arterial and venous thrombotic risk of the prothrombin 20210G/A genotype, analysing 204 consecutive DVT patients and 204 matched controls. Moreover, we analysed 213 carriers of the 20210G/A genotype (152 with DVT, 26 with arterial thrombosis and 35 healthy subjects) and 10 homozygous 20210 A/A carriers. We developed a simple method to simultaneously determine the genotype of both polymorphisms. In accordance with our case/control study, the A19911G polymorphism did not play a significant role in the development of DVT. Analysis of 120 20210 A alleles demonstrated a complete linkage disequilibrium with the 19911 A allele. These polymorphisms (alone or combined) did not modify the risk of arterial thrombosis. However, the 19911A/G genotype slightly increased the risk of developing DVT in carriers of the 20210G/A genotype (OR 3.34 vs 5.86), supporting that the prothrombin 19911 polymorphism could modulate the risk of the G20210A polymorphism in developing DVT. 相似文献
40.