首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   28412篇
  免费   1789篇
  国内免费   116篇
耳鼻咽喉   289篇
儿科学   801篇
妇产科学   598篇
基础医学   4262篇
口腔科学   2540篇
临床医学   2270篇
内科学   5654篇
皮肤病学   615篇
神经病学   2116篇
特种医学   753篇
外国民族医学   1篇
外科学   3109篇
综合类   389篇
一般理论   7篇
预防医学   3211篇
眼科学   357篇
药学   2030篇
中国医学   282篇
肿瘤学   1033篇
  2024年   59篇
  2023年   279篇
  2022年   661篇
  2021年   1065篇
  2020年   738篇
  2019年   926篇
  2018年   1062篇
  2017年   791篇
  2016年   809篇
  2015年   951篇
  2014年   1214篇
  2013年   1456篇
  2012年   2212篇
  2011年   2437篇
  2010年   1283篇
  2009年   963篇
  2008年   1609篇
  2007年   1508篇
  2006年   1386篇
  2005年   1134篇
  2004年   992篇
  2003年   893篇
  2002年   797篇
  2001年   558篇
  2000年   614篇
  1999年   486篇
  1998年   193篇
  1997年   154篇
  1996年   144篇
  1995年   129篇
  1994年   104篇
  1993年   87篇
  1992年   222篇
  1991年   210篇
  1990年   203篇
  1989年   196篇
  1988年   190篇
  1987年   151篇
  1986年   141篇
  1985年   135篇
  1984年   111篇
  1983年   86篇
  1981年   57篇
  1979年   85篇
  1978年   82篇
  1975年   59篇
  1974年   62篇
  1973年   62篇
  1970年   60篇
  1967年   54篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.

Objective

This study analyzed the degree of conversion (DC%) of four resin-based cements (All Ceram, Enforce, Rely X ARC and Variolink II) activated by two modes (chemical and dual), and evaluated the decrease of DC% in the dual mode promoted by the interposition of a 2.0-mm-thick IPS Empress 2 disc.

Material and Methods

In the chemical activation, the resin-based cements were prepared by mixing equal amounts of base and catalyst pastes. In the dual activation, after mixing, the cements were light-activated at 650 mW/cm2 for 40 s. In a third group, the cements were lightactivated through a 2.0-mm-thick IPS Empress 2 disc. The DC% was evaluated in a FT-IR spectrometer equipped with an attenuated total reflectance crystal (ATR). The data were analyzed by two-way ANOVA and Tukey''s HSD test.

Results

For all resin-based cements, the DC% was significantly higher with dual activation, followed by dual activation through IPS Empress 2, and chemical activation (p<0.05). Irrespective of the activation mode, Rely X presented the highest DC% (p<0.05). Chemically activated Variolink and All Ceram showed the worst results (p<0.05). The DC% decreased significantly when activation was performed through a 2.0-mm-thick IPS Empress 2 disc (p<0.05).

Conclusions

The results of the present study suggest that resin-based cements could present low DC% when the materials are dually activated through 2.0 mm of reinforced ceramic materials with translucency equal to or less than that of IPS-Empress 2.  相似文献   
82.
Idiopathic osteosclerosis (IO) is described as a localized no expansible radiopacity with unknown etiology. The IO is generally asymptomatic and could appear as round, elliptical or irregular in shape. The internal aspect is usually uniformly radiopaque. IO should be distinguished from condensing osteitis of dental origin, or other alveolar bone related radiopacities such as periapical cemental dysplasia. This condition may cause changes in tooth position or problems during orthodontic treatment. The purpose of the present study is to report a case of tooth resorption caused by ectopic eruption rote caused by IO. This condition represents a rare complication of IO.  相似文献   
83.
Background and Objective:  Chronic kidney disease (CKD) is a complex disorder, which results in several complications involving disturbance of mineral metabolism. Periodontal disease is an infectious disease that appears to be an important cause of systemic inflammation in CKD patients. Periodontal disease is characterized by clinical attachment loss (CAL) caused by alveolar bone resorption around teeth, which may lead to tooth loss. Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Polymorphisms are the main source of genetic variation, and single nucleotide polymorphisms (SNPs) have been reported as major modulators of disease susceptibility. The aim of this study was to investigate the association of a polymorphism located at position –223 in the untranslated region of the OPG gene, previously known as –950, with susceptibility to CKD and periodontal disease.
Material and Methods:  A sample of 224 subjects without and with CKD (in hemodialysis) was divided into groups with and without periodontal disease. The OPG polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism.
Results:  No association was found between the studied OPG polymorphism and susceptibility to CKD or periodontal disease.
Conclusion:  It was concluded that polymorphism OPG –223 (C/T) was not associated with CKD and periodontal disease in a Brazilian population. Studies on other polymorphisms in this and other genes of the host response could help to clarify the involvement of bone metabolism mediators in the susceptibility to CKD and periodontal disease.  相似文献   
84.
Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of the patients may develop regional distant metastases, and lungs and kidneys have been regarded as the most usual sites for implantation. There is, however, little information on the metastatic behavior of this malignancy. We report the first case of patient with multiple cutaneous metastases from a myoepithelial carcinoma of the submandibular gland, which depicted a very aggressive clinical course.  相似文献   
85.
The aim of this study was to investigate the flexural properties of five types of fiber-reinforced dowels using a modified three-point bending test. Fiber-reinforced resin dowels were tested by a modified three-point bending test associated with models for cylindrical and conical simple-supported beams. The fracture load ranged from 86 to 246 N and the flexural strength from 423 to 1192 MPa. FRC Postec had significantly higher flexural strength and fracture loads values. Thus, the present study demonstrated higher flexural strength values for the FRC Postec fibre posts, suggesting that this system would present a better response to the forces of mastication.  相似文献   
86.
Careful attention to malocclusion in children with special needs leads to a considerable improvement in the quality of life. The present study analysed the prevalence of malocclusion in children with Down syndrome (DS) and cerebral palsy (CP) as well as associations with individual, socio-economic, and behavioural factors. A cross-sectional study was carried out that included 181 mothers and their children with DS and CP (aged 3-12 years) at two institutions for individuals with special needs in Rio de Janeiro, Brazil. Data were collected using a questionnaire administered to the mothers and a dental examination of the children. Clinical examination recorded the following: anterior/posterior crossbite and anterior openbite (AOB). The control variables were the mother's level of education as well as the gender and age of the child. Statistical analysis of the data was performed using the chi-square test and multiple logistic regression. An anterior crossbite was present in 20.4 percent, a posterior crossbite in 21.5 percent, and an AOB in 29.8 percent. The presence of DS, bottle feeding, and non-nutritive sucking habits for 24 months or more was determinant factors for an anterior crossbite and the presence of DS, bottle feeding and non-nutritive sucking habits for 24 months or more, and respiratory infection in the previous 6 months was determinant factors for a posterior crossbite. The presence of CP and non-nutritive sucking habits for 24 months or more was determinant factors for an AOB. Thus, the prevalence of malocclusion in children with special needs was associated with the type of disability, use of bottle feeding and non-nutritive sucking habits for 24 months or more, and respiratory infection in the previous 6 months.  相似文献   
87.

Introduction

Apical periodontitis (AP) and cardiovascular diseases (CVDs) are chronic conditions triggered by an inflammatory process and sharing similar pathogeneses and molecular players. Previous studies have suggested that AP may perpetuate a systemic inflammation state and, in turn, contribute to CVD. In this study, we investigated the potential association between endodontic pathology and CVD using epidemiological and genetic approaches.

Methods

Epidemiologic analysis was performed by querying the medical and dental records of >2 million patients. We retrieved information on positive/negative history for endodontic pathologies and CVDs using diagnostic and treatment codes from a dental school–based and a hospital-based patient electronic health record system. A case-control genetic association study was also performed; 10 single nucleotide polymorphisms in genes identified as strongly associated with CVDs were genotyped in 195 cases with AP and 189 control individuals without AP. Data analyses were performed using the chi-square and Fisher exact tests. P ≤.05 indicates significant difference between groups.

Results

Significant associations were found between the presence of endodontic pathology and a history of hypertension, myocardial infarction, cerebrovascular accident, pacemaker, congestive heart failure, heart block, deep vein thrombosis, and cardiac surgery (0.0001 ≤ P ≤ .008). A modest association was found for heart murmur and atrial fibrillation (P = .04). A trend toward positive association (P = .05) was also found between AP and a single nucleotide polymorphism in KCNK3, a gene known to be involved in increased susceptibility to hypertension.

Conclusions

Significant associations were found between endodontic pathology and various CVDs and CVD-related risk factors, particularly hypertension. A trend toward a positive association was also found between AP and KCNK3, suggesting that common genetic variations may underlie different diseases. Additional studies with larger sample sizes have the potential to elucidate common mechanisms underlying AP and CVD.  相似文献   
88.
The aim of this ex vivo study was to compare visual clinical and radiographic examinations to the histological analysis for proximal caries diagnosis in extracted permanent molars and premolars. The relationship between clinical aspects and carious lesions was also evaluated. Eighty-eight proximal surfaces (44 freshly extracted teeth) were longitudinally sectioned with a 370-microm diamond disk, thinned with wet silicon carbide paper and observed with a stereomicroscope at x40 magnification. Sensitivity and specificity were 65.6% and 83.3% for clinical examination and 29.7% and 95.8% for radiographic examination, respectively. Kappa values ranged from 0.64 to 0.91. The white spots corresponded to lesions restricted to enamel, while the dark spots corresponded to lesions that reached the dentinoenamel junction. In most cases, cavitation corresponded to dentin lesions. It may be concluded that interproximal radiographic examination is not a reliable method for detection of incipient proximal carious lesions.  相似文献   
89.
The reliability and failure modes of molar crowns supported by three different implant-supported designs were tested according to the following groups: group 1, one standard-diameter implant (3.75 mm); group 2, one narrow-diameter implant (3 mm); and group 3, two narrow-diameter implants (3 mm). Loads were applied as mouth-motion cycles using a step-stress accelerated life-testing method. ? values for groups 1 and 3 (1.57 and 2.48, respectively) indicated that fatigue accelerated the failure of both groups, but not for group 2 (0.39). Abutment screw failure was the chief failure mode. Strength and reliability were significantly higher for groups 1 and 3 compared to group 2.  相似文献   
90.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号