Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts

Six cases of eruptive vellus hair cysts (EVHC) were evaluated for histopathology and the immunohistochemical profile of Ki‐67 and four keratins (K10, K14, K17 and K19). The pathological hallmark of EVHC was the existence of vellus hair shafts within the cystic cavity, but atypical pathological changes included two or three cysts and a foreign‐body granuloma in three cases. Our results demonstrate that atypical pathological changes are not uncommon in EVHC, and indicate that based on keratin expression, it is likely that EVHC is derived from the infrainfundibulum and sebaceous duct.     

护士主动报告护理不良事件影响因素的研究进展

阐述护士主动报告护理不良事件的现状,影响因素包括管理因素、文化因素、个人因素、工作环境因素,并提出构建以人为本的差错管理模式、营造开放的文化安全屏障,规范不良事件的管理文件,拓宽护理部管理职能、激励员工积极上报,倡导人文关怀、缓解护士压力等对策,为今后持续改进不良事件报告制度,构建高效、畅通、完善、人文化的报告系统提供参考。     

Investigation of Solid Dosage Form Components Interaction Using Orthogonal Techniques- Discovery of New Forms of Sodium Stearyl Fumarate

Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life and performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in DP under accelerated storage conditions. Due to the complex drug product matrix (including API, polymer, fillers, super disintegrant and lubricant), it was challenging to pinpoint the component(s) responsible for the new peak. In addition to PXRD, other orthogonal techniques including Differential Scanning Calorimetry (DSC), thermogravimetric analysis (TGA), dynamic vapor sorption (DVS), Solid State Nuclear Magnetic Resonance (SSNMR) and Infrared (IR) spectroscopy were employed in this investigation to understand the root cause mechanistically. Specifically, multi nuclei SSNMR (¹H, ²³Na, ¹³C) was instrumental in delineating the components of the matrix. We identified the root cause to be an acid base reaction occurring in the DP, whereby sodium ion in sodium stearyl fumarate (SSF) is replaced by proton leading to SSF form conversion. We also identified commercially available SSF to be a hydrate that can dehydrate to an anhydrous form upon heating. In general, the same techniques can be used to investigate interactions of any multi component solid dosage forms.     

新版GMP规范下无菌制剂洗烘灌封联动分装线URS

URS是设备采购的重要技术资料,针对新版GMP规范要求,结合洗烘灌封联动分装线系统及无菌制药工艺特点制定相关URS。     

A synthetic bandwidth method based on frequency-domain back projection for stepped-frequency SAR

For the drawbacks of the synthetic bandwidth method based on time-domain back projection, a novel synthetic bandwidth method based on frequency-domain back projection is proposed in this article for stepped-frequency synthetic aperture radar to improve the computation efficiency and to realize the automatic spatial spectra cutting. To give a direct and clear comprehension for wideband synthesizing in the spatial image space, the bandwidth and centre frequency for spatial image are defined for the first time. The simulation results validate the effectiveness of the proposed method.     

Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy

Circadian rhythm is a biological clock that controls a wide range of physiological functions throughout the body, including various skin functions. A 24‐h diurnal cycle, governed by an endogenous clock in the brain, largely controls cutaneous diurnal rhythm, which external factors, including temperature, humidity, diet, and stress, also modulate locally. Circadian rhythm influences cutaneous blood flow and properties of skin barrier function, such as transepidermal water loss and capacitance, and has important implications in atopic dermatitis (AD). This review explores how aberrations in circadian rhythm may play a role in the pathogenesis of AD and proposes implementation of chronotherapy to improve treatment outcomes in patients with AD.