全文获取类型
收费全文 | 539篇 |
免费 | 179篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 20篇 |
妇产科学 | 56篇 |
基础医学 | 53篇 |
口腔科学 | 6篇 |
临床医学 | 238篇 |
内科学 | 106篇 |
皮肤病学 | 12篇 |
神经病学 | 15篇 |
特种医学 | 26篇 |
外科学 | 58篇 |
综合类 | 4篇 |
一般理论 | 2篇 |
预防医学 | 51篇 |
眼科学 | 2篇 |
药学 | 7篇 |
中国医学 | 8篇 |
肿瘤学 | 54篇 |
出版年
2024年 | 3篇 |
2023年 | 26篇 |
2022年 | 9篇 |
2021年 | 25篇 |
2020年 | 25篇 |
2019年 | 8篇 |
2018年 | 43篇 |
2017年 | 49篇 |
2016年 | 43篇 |
2015年 | 44篇 |
2014年 | 49篇 |
2013年 | 45篇 |
2012年 | 35篇 |
2011年 | 27篇 |
2010年 | 26篇 |
2009年 | 52篇 |
2008年 | 17篇 |
2007年 | 19篇 |
2006年 | 38篇 |
2005年 | 13篇 |
2004年 | 15篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 14篇 |
1997年 | 16篇 |
1996年 | 13篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
排序方式: 共有720条查询结果,搜索用时 31 毫秒
51.
Margreet?Lüchtenborg Matty?P?WeijenbergEmail author Petra?A?Wark A?Merdan?Saritas Guido?MJM?Roemen Goos?NP?van Muijen Adriaan?P?de Bru?ne Piet?A?van den Brandt Anton?FPM?de Goeij 《BMC cancer》2005,5(1):160
Background
The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch repair deficiency. The aim of this study was to analyse the co-occurrence of these genetic alterations in relation to tumour and patient characteristics. 相似文献52.
Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury 总被引:2,自引:0,他引:2
Neonatal hypoxic-ischemic brain injury remains a significant cause of morbidity and mortality and lacks effective therapies for prevention and treatment. Recently, interest in the biology of polyphenol compounds has led to the discovery that dietary supplementation with foods rich in polyphenols (e.g. blueberries, green tea extract) provides neuroprotection in adult animal models of ischemia and Alzheimer's disease. We sought to determine whether protection of the neonatal brain against a hypoxic-ischemic insult could be attained through supplementation of the maternal diet with pomegranate juice, notable for its high polyphenol content. Mouse dams were provided ad libitum access to drinking water with pomegranate juice, at one of three doses, as well as plain water, sugar water, and vitamin C water controls during the last third of pregnancy and throughout the duration of litter suckling. At postnatal day 7, pups underwent unilateral carotid ligation followed by exposure to 8% oxygen for 45 min. Brain injury was assessed histologically after 1 wk (percentage of tissue area loss) and biochemically after 24 h (caspase-3 activity). Dietary supplementation with pomegranate juice resulted in markedly decreased brain tissue loss (>60%) in all three brain regions assessed, with the highest pomegranate juice dose having greatest significance (p < or = 0.0001). Pomegranate juice also diminished caspase-3 activation by 84% in the hippocampus and 64% in the cortex. Ellagic acid, a polyphenolic component in pomegranate juice, was detected in plasma from treated but not control pups. These results demonstrate that maternal dietary supplementation with pomegranate juice is neuroprotective for the neonatal brain. 相似文献
53.
Seeram E 《Radiologic technology》2005,76(6):449-459; quiz 460-2
The purpose of this paper is to describe the essential elements of digital image compression and its use in digital radiology. Additionally, this article is intended to increase the shared knowledge between radiologic technologists and radiologists, equipment vendors and information technology personnel. 相似文献
54.
The use of complementary and alternative medicine (CAM) has increased in the United States and more patients are seeking CAM therapies for control of pain. The present investigation tested the efficacy of orally administered anthocyanins extracted from tart cherries on inflammation-induced pain behavior in rats. Paw withdrawal latency to radiant heat and paw withdrawal threshold to von Frey probes were measured. The first set of experiments examined the effects of tart cherry anthocyanins (400 mg/kg) on the nociceptive behaviors and edema associated with inflammation induced by intraplantar injection of 1% carrageenan. These studies also included tests of motor coordination. The second set of experiments determined if tart cherry anthocyanins (15, 85, and 400 mg/kg) dose-dependently affected the inflammation induced by intraplantar injection of 25% complete Freund's adjuvant. We found that tart cherry extracts reduce inflammation-induced thermal hyperalgesia, mechanical hyperalgesia and paw edema. The suppression of thermal hyperalgesia was dose-dependent and the efficacy of highest dose (400 mg/kg) was similar to indomethacin (5 mg/kg). The highest dose anthocyanin (400 mg/kg) had no effects on motor function. These data suggest that tart cherry anthocyanins may have a beneficial role in the treatment of inflammatory pain. The antihyperalgesic effects may be related to the anti-inflammatory and antioxidant properties of anthocyanins. A better understanding of the modulatory role of dietary constituents and phytonutrients on pain will offer further therapeutic options for treating patients with persistent and chronic pain conditions. 相似文献
55.
Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. A previously reported association with mental retardation or cerebral palsy is not confirmed. 4 out of the 21 children had early speech problems. 相似文献
56.
57.
Williamson MR; Boyd CM; McGuire EL; Angtuaco T; Westbrook KC; Lang NP; Alston J; Broadwater JR; Navab F; Bersey ML 《Radiology》1986,159(1):272-273
The nuclear medicine bleeding scan is frequently insufficient to locate sites of bleeding precisely, in spite of its great sensitivity. A small, hand-held Geiger-Müller counter, placed directly on exposed intestine in the operating room, enables precise location of the probable bleeding site. In three patients, the technique allowed a minimal amount of intestine to be resected, distinguished between large- and small-intestinal hemorrhage, and eliminated other foci as sites of bleeding. 相似文献
58.
Nicholas M. Barbaro MD Mark Quigg MD MSc Donna K. Broshek PhD Mariann M. Ward RN NP Kathleen R. Lamborn PhD Kenneth D. Laxer MD David A. Larson PhD MD William Dillon MD Lynn Verhey PhD Paul Garcia MD Ladislau Steiner MD PhD Christine Heck MD Douglas Kondziolka MD MSc Robert Beach MD William Olivero MD Thomas C. Witt MD Vicenta Salanova MD Robert Goodman MD 《Annals of neurology》2009,65(2):167-175
59.
60.
Kathleen R. Delaney RN NP DNSc 《Journal of child and adolescent psychiatric nursing》2006,19(4):170-174
On child and adolescent inpatient psychiatric units, nursing staff have 24-hour exposure to patients, an excellent vantage point for observing behavior in a variety of situations and interpersonal contexts. How staff members respond to milieu behaviors depends in part on their judgment of what prompted a youngster's response and his/her ability to process the event and control the attendant emotions. To assess such aspects of a child or adolescent's presentation requires that staff appraise not just the presenting behavior but the patient's information-processing and affect-regulation abilities. One way this developmental knowledge can be embedded in practice is through assessment guides that contain observation cues for key issues related to how children/adolescents think, feel, and behave. This article sets down the rationale for the content and organization of such inpatient nursing assessment guides and suggestions for their dissemination to the unit staff. 相似文献