Inhibitory effect of aerial parts of Scrophularia striata on matrix metalloproteinases expression

It has been shown that destruction of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) leads to tumor invasion, metastasis and angiogenesis. The aim of the present research was to verify the effects of a total extract and sequential extracts of Scrophularia striata Boiss (Scrophulariaceae) on MMPs activity. The fibro sarcoma cell line (wehi-164) was used to assess MMPs inhibitory effect. The MMPs activity was evaluated using a zymoanalysis method. The results of this study showed that the highest MMPs inhibitory effect (55.6%) was observed after treatment with 10 microg/mL of the high polarity methanol solution extract corresponding to its lowest cytotoxicity effect (4%). It is concluded that the aerial parts of S. striata might contain various polar compounds that inhibit MMPs.     

Acute ischemic stroke and convexity subarachnoid hemorrhage in large vessel atherosclerotic stenosis: Case series and review of the literature

Atraumatic convexity subarachnoid hemorrhage (cSAH) is a rare non‐aneurysmal SAH, commonly due to ipsilateral internal carotid artery (ICA) stenosis. It is unusual for the cSAH to occur contralaterally to the infarct. We report two cases of acute ischemic stroke associated with contralateral and ipsilateral cSAH that had different presentations.