Relationship between the Mutation of IRS-1 Gene and β_3-adrenergic Receptor Gene

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Translating clinical and patient-reported data to tailored shared decision reports with predictive analytics for knee and hip arthritis

Quality of Life Research - New informatics tools can transform evidence-based information to individualized predictive reports to serve shared decisions in clinic. We developed a web-based system...     

CORDIC算法在B超数字扫描变换器中的应用

数字扫描变换器在B型超声诊断仪的应用，能使现代实时B型超声诊断仪实现一些新的诸如图像冻结、多帧贮存、数据测量计算和TV显示等功能。在设计B型超声诊断仪中数字扫描变化器的过程中，直角坐标到极坐标变换是一个关键的技术，本研究论述了应用在数字扫描变化器中的一种新的算法——CORDIC算法，对该算法的原理进行了简介，将CORDIC算法应用到直角——极坐标变换中，并进行了算法修正和公式计算。根据其具体的应用对该算法进行了优化，并给出了算法的硬件实现结构。最后，对算法进行了软件仿真，并给出了结果分析。     

微波体模

用水、盐,聚氯乙烯粉和羧甲基纤维钠四种材料配制成一种适用的微波体模(模拟肌肉组织)。该体模的复介电系数在300～2500MHz范围内与实际人体肌肉组织的误差≤5％。这种体模的优点是材料立足国内,价廉,室温下配制,使用方便。本文也给出这种体模的温度特性,稳定性和热学特性,供电磁场生物效应和微波热疗等研究使用。     

肱桡肌皮瓣的应用解剖学研究

通过尸体解剖,观察了64侧肱桡肌的形态及其主要供血血管——桡侧返动脉的来源、起始部位、主干长度、外径、行经及分支分布。通过动脉内墨汁注射,观察了桡侧返动脉在肱桡肌皮瓣的皮肤供血范围。认为可以桡侧返动脉为蒂的肱桡肌皮瓣转移复盖肘关节的暴露伤及邻近的软组织缺损。也可制成带蒂的肌皮瓣作游离移植。文内讨论了该瓣的优缺点及转移复盖的范围。     

Relationship between age and effect of early and long-term captopril treatment in patients with acute myocardial infarction

Objective To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI). Methods In a randomized trial, 822 patients with a first AMI received conventional medic al treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly allocated to captopril ［dosage fr om the first 6.25 mg to 25 mg/t.i.d, 209 younger patients (≤64 years), 269 elderly patients (65-75 years)］ or conventional treatment only (131 younger p atients, 213 elderly). Survival in the four groups was calculated with the Kapl an-Meier method. Multivariate analysis was performed to understand the degree that multi-variables (including age) affect survival in patients taking captopr il in the hospital or during long term follow-up. Results The survival of patients who took captopril correlated significantly with age ( P<0.001). The survival of the elderly patients on captopril treatment did increase (P<0.0001), but not of the younger ones (P>0.05) during hosp italization. During follow-up, the survival of patients who took captopril cor related insignificantly with age (P>0.05), but both the elderly and the you n ger patients have good survival rates (all P<0.01) and lower cardiac events (all P<0.01) when they took captopril.Conclusions Captopril exerts a weak effect on the younger patients but a beneficial effect o n the elderly patients during hospitalization after AMI. However, there is no d ifference between the younger and the elderly in the prognosis, both having good survival and lower cardiac events when they take captopril long term during fol low-up.     

普罗布考对体外培养的主动脉平滑肌细胞NF—kB活性的影响

目的：观察普罗布考（probucol)对血管平滑肌细胞（VSMCs)核因子kB(NF-kB)活性的调控作用,以探讨probucol在动脉粥样硬化（AS）和经皮腔内冠状动脉成形术后再狭窄（RS）防治中的某些可能的作用机制。方法：采用电泳迁移位移测定法观察probucol对VSMCsNF-kB活性的影响。结果：H2O2或胎牛血清（NCS）处理VSMCs72h后,NF-kB活性均明显增强;而加入100umol/Lprobucol后,NF-kB活性受到部分抑制,抑制率分别为37.1%和14.8%。结论：Probucol抑制NCS、H2O2诱导的VSMCsNF-kB的活性,可能是其临床有效防治RS及AS的作用机制之一。     

小儿喘咳液对哮喘豚鼠肺超微结构变化的电镜观察

利用透射式电子显微镜观察小儿喘咳液对过敏性哮喘豚鼠肺超微结构变化情况。结果显示:连续雾化吸入卵清蛋白后第1d肺毛细血管壁充血并挤压毛细血管壁,第8d肺毛细血管壁增厚,胶原纤维增生。而用小儿喘咳液连续治疗7d后肺毛细血管壁增厚程度减轻,无胶原纤维增生。证明小儿喘咳液对哮喘有良好的治疗效果。     

蛋白酪氨酸磷酸酶H 型受体的生物学功能及其在肿瘤中的研究进展

蛋白酪氨酸磷酸酶H型受体(protein tyrosine phosphatase H receptor,PTPRH)基因是一种编码胃癌相关蛋 白的基因,通过翻译后COOH-末端区域的酪氨酸磷酸化修饰发挥其生物学功能。PTPRH在多种肿瘤中呈异常表达, 其生物学功能与肿瘤的发生、发展及预后密切相关。