全文获取类型
收费全文 | 7982篇 |
免费 | 385篇 |
国内免费 | 156篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 226篇 |
妇产科学 | 157篇 |
基础医学 | 1015篇 |
口腔科学 | 146篇 |
临床医学 | 725篇 |
内科学 | 1824篇 |
皮肤病学 | 164篇 |
神经病学 | 503篇 |
特种医学 | 804篇 |
外科学 | 929篇 |
综合类 | 62篇 |
预防医学 | 259篇 |
眼科学 | 81篇 |
药学 | 736篇 |
2篇 | |
中国医学 | 92篇 |
肿瘤学 | 725篇 |
出版年
2023年 | 33篇 |
2022年 | 140篇 |
2021年 | 223篇 |
2020年 | 113篇 |
2019年 | 160篇 |
2018年 | 184篇 |
2017年 | 159篇 |
2016年 | 212篇 |
2015年 | 288篇 |
2014年 | 330篇 |
2013年 | 392篇 |
2012年 | 553篇 |
2011年 | 547篇 |
2010年 | 433篇 |
2009年 | 310篇 |
2008年 | 440篇 |
2007年 | 444篇 |
2006年 | 353篇 |
2005年 | 339篇 |
2004年 | 269篇 |
2003年 | 219篇 |
2002年 | 180篇 |
2001年 | 173篇 |
2000年 | 169篇 |
1999年 | 132篇 |
1998年 | 176篇 |
1997年 | 190篇 |
1996年 | 161篇 |
1995年 | 133篇 |
1994年 | 128篇 |
1993年 | 108篇 |
1992年 | 56篇 |
1991年 | 68篇 |
1990年 | 64篇 |
1989年 | 81篇 |
1988年 | 68篇 |
1987年 | 66篇 |
1986年 | 64篇 |
1985年 | 65篇 |
1984年 | 38篇 |
1983年 | 26篇 |
1982年 | 29篇 |
1981年 | 35篇 |
1980年 | 31篇 |
1979年 | 12篇 |
1978年 | 13篇 |
1977年 | 21篇 |
1976年 | 29篇 |
1975年 | 16篇 |
1969年 | 7篇 |
排序方式: 共有8523条查询结果,搜索用时 15 毫秒
991.
992.
Park do J Han SU Hyung WJ Kim MC Kim W Ryu SY Ryu SW Song KY Lee HJ Cho GS Kim HH;Korean Laparoscopic Gastrointestinal Surgery Study 《Surgical endoscopy》2012,26(6):1548-1553
Background
Recently, the number of laparoscopic procedures for gastric cancer has increased rapidly. Laparoscopic surgery is reported to have many advantages over open gastrectomy with oncologic safety in early gastric cancer. However, there were few reports on long-term outcomes of laparoscopy-assisted gastrectomy (LAG) for advanced gastric cancer (AGC). The aim of this study was to investigate long-term survival outcomes after LAG for AGC.Methods
The data of 1,485 patients who underwent LAG between April 1998 and December 2005 by ten surgeons at ten hospitals were collected retrospectively. Among them, 239 patients who were diagnosed with AGC on final pathologic examination were enrolled in the present study to investigate long-term clinical outcomes.Results
The ratio of male to female patients was 151:88 and the mean age was 57.1?years. One hundred ninety-three subtotal gastrectomies, 41 total gastrectomies, and 5 proximal gastrectomies were performed. D1?+?α, D1?+?β, and D2 lymph node dissections were performed for 14, 62, and 163 cases, respectively. The median follow-up period was 55.4?months. The overall 5-year survival rate of the 239 AGC patients was 78.8% and the disease-specific 5-year survival rate was 85.6%. The 5-year survival rates of the TNM staging system’s (7th ed.) stages were 90.5% (stage Ib, n?=?86), 86.4% (stage IIa, n?=?53), 78.3% (stage IIb, n?=?44), 52.8% (stage IIIa, n?=?24), 52.9% (stage IIIb, n?=?24), and 37.5% (stage IIIc, n?=?8) (p?0.001).Conclusion
The long-term survival outcome rates of LAG for AGC in the present study were comparable to those previously reported for open gastrectomy. Based on the present results, a well-designed phase III trial comparing LAG and open gastrectomy for AGC will be needed to affirm the validity of LAG for AGC. 相似文献993.
994.
995.
Kim BJ Lee YS Lee SY Park SY Dieplinger H Ryu SH Yea K Choi S Lee SH Koh JM Kim GS 《BONE》2012,51(3):431-440
Although it is well known that osteoclastic bone resorption is followed by osteoblastic bone formation, questions remain as to when coupling factors are produced during bone resorption and which stages of bone formation are affected by these factors. To clarify these mechanisms, we established an in vitro system to investigate the coupling phenomenon. We obtained conditioned media (CM) from osteoclasts in the early and late stages of differentiation and from bone resorption stages. The collected CM was used to treat primary mouse calvarial osteoblasts and preosteoblastic MC3T3-E1 cells and to evaluate its influence on the migration, viability, proliferation, and differentiation of osteoblasts. We found that CM from osteoclasts in the early stage of differentiation predominantly stimulated the migration of osteoblastic lineages. By further performing fractional analyses of the CM with liquid chromatography-tandem mass spectrometry, we identified afamin, which has binding activity with vitamin E, as a possible coupling factor. The CM collected from afamin siRNA-transfected osteoclasts significantly suppressed preosteoblast migration. Afamin activated Akt in preosteoblasts, and pretreatment with Akt inhibitor significantly blocked afamin-stimulated preosteoblast migration. In conclusion, these results indicate that osteoclasts themselves play a central role in the coupling of bone resorption and formation by stimulating preosteoblast migration. In addition, we identified afamin as one of osteoclast-derived chemokines that affect preosteoblasts through the activation of the Akt-signaling pathway. 相似文献
996.
997.
998.
Ryu Kanzaki Naoki Ikeda Eiji Okura Naoto Kitahara Akira Okimura Kunimitsu Kawahara Mitsunori Ohta 《General thoracic and cardiovascular surgery》2012,60(12):855-858
Pulmonary carcinosarcoma is a rare disease entity defined as a neoplasm, which has biphasic features consisting of both epithelial and sarcomatous components. It has been reported that the most frequent epithelial component is squamous cell carcinoma, while the most frequent sarcomatous component is rhabdomyosarcoma. Pulmonary carcinosarcomas with osteosarcoma components are even rarer. We report a case of a potentially curative resection for carcinosarcoma with an osteosarcoma component. Thoracic surgeons should be aware of this rare tumor when lung tumors with ossification are encountered. 相似文献
999.
Tsukioka T Yamamoto R Takahama M Nakajima R Tada H 《General thoracic and cardiovascular surgery》2012,60(9):618-620
A 48-year-old man with fever and dry cough was admitted to our hospital. Imaging examinations revealed a mass lesion with calcification in the right B(3)b bronchus and atelectasis in the distal lung area. Subsequently, right S(3) segmentectomy was performed. There was a hard polypoid mass completely obstructing the right B(3)b bronchus. Histopathological findings suggested a metaplastic bone formation with mature bone marrow tissue leading to the primary bronchial cartilage. A case of ectopic bone formation in subsegmental bronchus has never been reported thus far. The resident fibroblasts might transform into osteoblasts under appropriate environmental conditions and induce bone formation. 相似文献
1000.
Young Kyung Yoon Dae Won Park Jang Wook Sohn Hyo Youl Kim Yeon-Sook Kim Chang-Seop Lee Mi Suk Lee Seong-Yeol Ryu Hee-Chang Jang Young Ju Choi Cheol-In Kang Hee Jung Choi Seung Soon Lee Shin Woo Kim Sang Il Kim Eu Suk Kim Jeong Yeon Kim Kyung Sook Yang Kyong Ran Peck Min Ja Kim 《Antimicrobial agents and chemotherapy》2014,58(1):317-324
The purpose of this study was to compare the clinical efficacy and safety of vancomycin to those of teicoplanin for the treatment of adult patients with health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) bacteremia. A multicenter observational study was prospectively conducted in 15 teaching hospitals in Korea between February 2010 and July 2011. Adult patients (≥18 years old) with HA-MRSA bacteremia who were initially treated with vancomycin (VAN) (n = 134) or teicoplanin (TEC) (n = 56) were enrolled. Clinical and microbiological responses and drug-related adverse events were compared between the two treatment groups using univariate and multivariate logistic regression analyses. The vancomycin and teicoplanin MICs were determined by Etest. The MRSA-related mortality, duration of fever, and duration of MRSA bacteremia in the treatment groups were not significantly different. There was no significant difference in the occurrence of drug-related adverse events. Among the 190 MRSA isolates, the VAN MICs ranged from 0.5 to 2 μg/ml (MIC50 and MIC90, 1.5 μg/ml), and the TEC MIC ranged from 0.5 to 8 μg/ml (MIC50, 3 μg/ml; MIC90, 6 μg/ml). In multivariate analyses, the antibiotic type (vancomycin or teicoplanin) was not associated with treatment outcomes. This study indicates that teicoplanin is an effective and safe alternative to vancomycin for the treatment of HA-MRSA bacteremia. 相似文献