Optimal Granule Combination Selection Based on Multi-Granularity Triadic Concept Analysis

The thinking mode based on granule structure in granular computing essentially simulates the pattern of human thinking to solve problem. Such thinking for the study of knowledge discovery is also of significant importance in cognitive computing. Under such circumstances, the theory of multi-granularity formal concept analysis (MG-FCA) was proposed. But MG-FCA has not been applied to the analysis of three-dimensional data. Because three-dimensional data is very common and an important type of data in the real world, multi-granularity and knowledge discovery of three-dimensional data are two meaningful topics. In this paper, in order to solve the problem of three-dimensional data granularity, the idea of granularity of attributes is first introduced into triadic contexts on the basis of the relationship between triadic concept analysis and formal concept analysis. Moreover, the definition of multi-granularity triadic context is proposed, and some useful properties are studied. Then, for the purpose of realizing cross-granularity knowledge discovery in multi-granularity triadic contexts, two kinds of triadic contexts are given. As a matter of fact, for a specific problem, people often only need a solution to meet their needs. Thus, the problem of optimal granule combination selection is investigated, and the corresponding algorithms are explored. At last, for better understanding, an example with certain semantics is used to explain the proposed methods for multi-granularity triadic contexts. The main contribution as well as the significant feature of this study is to construct multi-level three-dimensional data structure and realize cross-granularity knowledge discovery. Our work will provide multi-granularity cognitive research method based on three-dimensional data.

     

皮肤干细胞的定位

应用计算机检索Pubmed数据库1990-2008年、中文期刊全文数据库1998．2008年与皮肤干细胞定位相关的文献，44篇文献资料分析结果显示，毛囊bulge区细胞具有高度增殖潜能，为标记滞留细胞，具有多向分化潜能，不表达分化细胞特异性标志，表达干细胞标志，为目前公认的表皮干细胞的定居处。毛囊真皮鞘包含具有可塑性的干细胞，认为是真皮干细胞的定居处。毛囊真皮乳头内含有具一定增殖分化能力的前体细胞，与真皮鞘相互作用，能够诱导毛囊形成，目前观点认为，真皮乳头内前体细胞移行自真皮鞘干细胞，为其活化的子代细胞。毛囊间皮肤与无毛区皮肤是否存在皮肤干细胞尚存争论，部分实验表明，毛囊间表皮基底层亦有表皮干细胞的存在。     

动物模型中人骨形态发生蛋白2重组腺病毒活性观测

目的:利用基因工程技术构建人骨形态发生蛋白2重组腺病毒,并进行体内表达,测定活性;为深入开展的基因治疗研究创造条件。方法:实验于2000-05/2002-06在西安交通大学第一附属医院骨科实验室完成。应用PCR技术扩增出人骨形态发生蛋白2全长基因,体外同源重组构建重组腺病毒后,随机将30只SD大鼠分为治疗组和对照组,每组15只,将纯化后的重组腺病毒50μL注入SD大鼠股部肌肉陷窝病损处,通过组织学染色、X射线片对动物模型的组织变化进行观测。结果:6周后治疗组可见明显骨诱导形成,2周时治疗组碱性磷酸酶活性明显高于对照组,重组腺病毒治疗组有明显的诱导成骨活性。结论:应用于动物实验中目的基因表达,并具有生物学活性。本研究是在骨缺损基因治疗的一次尝试,且人骨形态发生蛋白2重组腺病毒的构建成功,也为国内骨科疾病基因治疗的进一步研究提供了基础。     

手法联合核心稳定训练治疗老年非特异性腰痛临床研究

目的:观察手法联合核心稳定训练治疗老年非特异性腰痛的临床疗效。方法:124例随机分为研究组和对照组各62例。两组均行手法治疗,观察组加用核心稳定训练治疗。结果:治疗后两组VAS、ODI评分均较治疗前改善(P<0.01),观察组改善程度优于对照组(P<0.01)。治疗后两组闭眼单脚站立时间、闭目原地踏步时间均较治疗前延长(P<0.01),观察组延长程度大于对照组(P<0.05)。结论:手法可以瞬间纠正腰椎“骨错缝、筋出槽”,恢复力学平衡。配合核心稳定性训练,使筋强骨健,维持腰椎稳定,疗效较好且安全。     

Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: a 12-year experience.

OBJECTIVE: To evaluate the clinical utility of sonography with Doppler examination in the diagnosis and treatment of gestational trophoblastic disease (GTD). METHODS: A retrospective analysis of 355 cases of GTD seen over a 12-year period in 2 large university referral hospitals in China was performed. Clinical appearances, sonographic findings, Doppler waveforms, and patient outcomes were reviewed. Sonographic and Doppler examinations were performed to diagnose the presence of molar tissue, detect invasive disease, assess disease recurrence, and monitor the efficacy of chemotherapy. Doppler waveforms of 13 patients with normal early pregnancies were also examined for comparison. RESULTS: Of the 355 patients with GTD, 106 had a classic hydatidiform mole (CHM), 33 had a partial hydatidiform mole (PHM), 184 had an invasive hydatidiform mole (IHM), and 32 had choriocarcinoma. Sonography showed abnormal molar tissue confined to the endometrial cavity in all cases of CHM. In cases of IHM and choriocarcinoma, soft tissue invasion and cystic vascular spaces within the myometrium were shown. Cases of PHM had a thickened, hydropic placenta with a concomitant fetus. Doppler waveforms showed resistive indices of 0.55 (SD, 0.06) for CHM, 0.56 (SD, 0.04) for PHM, 0.28 (SD, 0.06) for IHM, 0.25 (SD, 0.05) for choriocarcinoma, and 0.66 (SD, 0.04) for normal pregnancies. The abnormal sonographic and Doppler findings in invasive disease resolved when chemotherapy was successful. CONCLUSIONS: Sonography and Doppler imaging were helpful in diagnosing GTD, in determining whether invasive disease was present, in detecting recurrence of disease, and in following the effectiveness of chemotherapy.     

超声波对儿童腰骶椎畸形的诊断价值

将超声波、放射学和解剖学对脊柱腰骶段检查结果作了比较。依次在２１例３０～４０孕周的死胎上做了超声波和放射学检查（普通Ｘ片照像，其中１０例加做ＣＴ检查），并将结果与解剖学结果比较。所有放射学检查结果显示正常腰骶椎图像。１９例超声波与解剖学结果一致，其中１例为隐性脊柱裂。另各有１例超声波检查假阳性和假阴性。根据检查结果，我们认为儿童腰骶椎畸形的诊断可首选脊柱超声波检查。     

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

AIM: To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and type 2 diabetic retinopathy (DR). METHODS: A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus (DM, n=100), non-proliferative diabetic retinopathy (NPDR, n=62) and proliferative diabetic retinopathy (PDR, n=38). 100 healthy persons were selected as the normal control group (NCG, n=100). The related indicators, such as neutrophil count, lymphocyte count and platelet count, were measured. RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group (1.81), DM group (1.76) and NPDR group (1.85) (P<0.05). The value of PLR was significantly higher in PDR group patients (126.18) than in DM group (111.64) (P<0.05). Logistic regression analysis showed that age (β= -0.047) was protective factor, course of diabetes (β=0.071) and systolic blood pressure (β=0.024) were risk factors for diabetic retinopathy (P<0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis. CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.     

Changes in Early Serum Metal Ion Levels and Impact on Liver,Kidney, and Immune Markers Following Metal-on-Metal Total Hip Arthroplasty

We retrospectively studied 32 consecutive patients (32 hips) who underwent THA with a Durom large-head, MOM articulation between January 2008 and December 2010. Of the patients who underwent THA using a Trilogy metal on polyethylene prosthesis during the same period, 32 were chosen to form the Trilogy group. 32 volunteers were chosen to form the control group. At the last follow-up, serum metal ion levels, liver and kidney function and host immunologic immune responses were evaluated. The mean Co and Cr levels in the Durom group were 4.33- and 1.95-fold higher than those in the Trilogy group. CD3 +, CD4 + and CD8 + cell levels in the Durom group were significantly decreased. The INF-γ level in the Durom group was significantly higher than that in the Trilogy and control groups.