全文获取类型
收费全文 | 418篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 22篇 |
妇产科学 | 30篇 |
基础医学 | 53篇 |
口腔科学 | 4篇 |
临床医学 | 46篇 |
内科学 | 97篇 |
皮肤病学 | 12篇 |
神经病学 | 33篇 |
特种医学 | 4篇 |
外科学 | 35篇 |
预防医学 | 52篇 |
眼科学 | 3篇 |
药学 | 23篇 |
中国医学 | 18篇 |
肿瘤学 | 16篇 |
出版年
2023年 | 8篇 |
2022年 | 13篇 |
2021年 | 22篇 |
2020年 | 18篇 |
2019年 | 13篇 |
2018年 | 19篇 |
2017年 | 12篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 24篇 |
2013年 | 22篇 |
2012年 | 31篇 |
2011年 | 22篇 |
2010年 | 20篇 |
2009年 | 12篇 |
2008年 | 21篇 |
2007年 | 17篇 |
2006年 | 20篇 |
2005年 | 21篇 |
2004年 | 15篇 |
2003年 | 14篇 |
2002年 | 18篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 6篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1981年 | 1篇 |
排序方式: 共有451条查询结果,搜索用时 15 毫秒
1.
On the basis of earlier success in rat studies, chlorpromazine was evaluated as a probable agent for improving survival of random skin flaps in pigs. The aim was to exclude the possibility that the effect of the chlorpromazine is species specific and to find out if it is dose dependent. One hundred and five dorsally-based 12×4 cm flaps were raised unilaterally on the backs of 15 pigs. The animals were divided into three groups using 15 mg/kg chlorpromazine, 7.5 mg/kg chlorpromazine, and a saline-treated control group. Flaps in the control group averaged 40.57±3.17% necrosis, while flaps in the 15 mg/kg and 7.5 mg/kg chlorpromazine-treated groups averaged 31.53±4.77% and 11.47±2.22% necrosis respectively. These results demonstrate dose dependent beneficial affects of chlorpromazine and the survival of random skin flaps in the pig. Although ideal dose levels are still to be determined, flap survival improved with the prophylactic use of chlorpromazine at the lower 7.5 mg/kg dosage. 相似文献
2.
Comparison of positive allergy skin tests among asthmatic children from rural and urban areas living within small geographic area. 总被引:1,自引:0,他引:1
Haim Bibi David Shoseyov David Feigenbaum Pnina Nir Rosa Shiachi Shimon Scharff Ronit Peled 《Annals of allergy, asthma & immunology》2002,88(4):416-420
BACKGROUND: Evidence of increased asthma and allergic response among urban versus rural residents has been reported. OBJECTIVE: To evaluate the prevalence of allergic response among asthmatic children from urban and rural areas living within close proximity. METHODS: In all, 448 asthmatic children from urban (363) and rural (85) areas were studied. The study group consisted of 234 9-year-olds and 214 12-year-olds. A health questionnaire was completed on each child who subsequently underwent allergic skin prick tests (SPTs). RESULTS: There was significantly more positive SPT response to house-dust mite, mold, cat, and cypress among asthmatic children from urban areas compared with children living in rural areas: 58.3% versus 37.6%, 46.1% versus 31.8%, 17.45 versus 5.9%, and 26.2% versus 15.3%, respectively. Positive SPT for indoor allergens were significantly greater among asthmatic urban residents than asthmatic rural residents: 63.3% versus 45.5%, respectively (P < 0.02). Positive SPT response to all the allergens checked was higher among the 12-year-old age group when compared with the 9-year-olds, 34.6% versus 22.7%, respectively (P = 0.05). CONCLUSIONS: Allergic response measured by SPT is significantly more common among asthmatic children from urban areas as opposed to rural, even though both areas are within small distance of one another. Further, asthmatic children living in urban areas demonstrated more allergic response to both indoor and outdoor allergens. The allergic response tends to increase with increased age in both urban and rural asthmatic children. 相似文献
3.
Sahar rajabzadeh Karizi Fatemeh Armanmehr Hamideh Ghodrati Azadi Hojjat Shadman Zahroodi AmirAli Moodi Ghalibaf Bibi Sedigheh Fazly Bazzaz Mohammadreza Abbaspour Javad Boskabadi Saeid Eslami Zhila Taherzadeh 《Phytotherapy research : PTR》2023,37(4):1435-1448
The efficacy of spirulina platensis (S. platensis) as an add-on therapy to metformin and its effect on atherogenic keys in patients with uncontrolled Type 2 Diabetes Mellitus (T2DM) was evaluated. Sixty patients were randomly assigned to S. platensis (2 g/day) or placebo group for three months while continuing metformin as their usual treatment. The efficacy of S. platensis was determined using the pre- and post-intervention HbA1c levels (primary outcome) as well as tracking FBS and lipid profiles levels (TC, LDL-C, TG, and HDL-C) as secondary outcomes at the different treatment time points (0,30,60,90 days). During the three–month intervention period, supplementation with S. platensis resulted in a significant lowering of HbA1c (↓1.43, p < 0.001) and FBS (↓ 24.94 mg/dL, p < 001) levels. Mean TG in the intervention group was found to be significantly lower in the intervention group than in controls (p < 0.001). Total cholesterol (TC) and its fraction, LDL-C, exhibited a fall (↓41.36 mg/dL and ↓38.4 mg/dL, respectively; p < 0.001) coupled with a marginal increase in the level of HDL-C (↑3 mg/dL; p < 0.001). Add-on therapy with S. platensis was superior to metformin regarding long-term glucose regulation and controlling blood glucose levels of subjects with T2DM. Also, as a functional supplement, S. platensis has a beneficial effect on atherogenic keys (TG and HDL-C) with no adverse events. 相似文献
4.
5.
Cultivating a culture of research in nursing through a journal club for leaders: A pilot study
下载免费PDF全文
![点击此处可从《Journal of nursing management》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mette Kjerholt RN MScN PhD Bibi Hølge‐Hazelton RN MScN PhD 《Journal of nursing management》2018,26(1):42-49
Aim
To describe whether an action learning‐inspired journal club for nurse leaders can develop the leaders' self‐perceived competences to support a research culture in clinical nursing practice.Background
Development of clinical research capacity and nurse leaders with the requisite competences are key factors in evidence‐based health care practice. This study describes how nurse leaders at a large regional hospital took part in a journal club for nurse leaders, with a view to developing their competences to support a nursing research culture in their departments.Methods
A pilot study using a multimethod approach to evaluate the journal club for nurse leaders. Four nurse leaders participated in the journal club for nurse leaders. Content analysis on the data was performed.Results
Data revealed that participation in journal club for nurse leaders gave the leaders a feeling of increased competences to support nursing research culture in their departments. They stated that the action learning approach and the competences of the facilitator were key factors in this outcome.Conclusions
An action learning‐inspired journal club for nurse leaders can be useful and meaningful to nurse leaders in developing leadership competences.Implications for nursing management
As an approach in journal club for nurse leaders, action learning can develop nurse leaders' competence to support a research culture, and thus ensure evidence‐based nursing is practised. 相似文献6.
MA Barone V Frajzyngier J Ruminjo F Asiimwe TH Barry A Bello D Danladi SO Ganda S Idris M Inoussa M Lynch F Mussell DC Podder 《Obstetrics and gynecology》2012,120(3):524-531
OBJECTIVE:: To determine predictors of fistula repair outcomes 3 months postsurgery. METHODS:: We conducted a multicountry prospective cohort study between 2007 and 2010. Outcomes, measured 3 months postsurgery, included fistula closure and residual incontinence in women with a closed fistula. Potential predictors included patient and fistula characteristics and context of repair. Multivariable generalized estimating equation models were used to generate adjusted risk ratios (RRs) and 95% confidence intervals (CIs). RESULTS:: Women who returned for follow-up 3-month postsurgery were included in predictors of closure analyses (n=1,274). Small bladder size (adjusted RR 1.57, 95% CI 1.39-1.79), prior repair (adjusted RR 1.40, 95% CI 1.11-1.76), severe vaginal scarring (adjusted RR 1.56, 95% CI 1.20-2.04), partial urethral involvement (adjusted RR 1.36, 95% CI 1.11-1.66), and complete urethral destruction or circumferential defect (adjusted RR 1.72, 95% CI 1.33-2.23) predicted failed fistula closure. Women with a closed fistula at 3-month follow-up were included in predictors of residual incontinence analyses (n=1,041). Prior repair (adjusted RR 1.37, 95% CI 1.13-1.65), severe vaginal scarring (adjusted RR 1.35, 95% CI 1.10-1.67), partial urethral involvement (adjusted RR 1.78, 95% CI 1.27-2.48), and complete urethral destruction or circumferential defect (adjusted RR 2.06, 95% CI 1.51-2.81) were significantly associated with residual incontinence. CONCLUSION:: The prognosis for genital fistula closure is related to preoperative bladder size, previous repair, vaginal scarring, and urethral involvement. LEVEL OF EVIDENCE:: II. 相似文献
7.
Estimation of copper in saliva and areca nut products and its correlation with histological grades of oral submucous fibrosis
下载免费PDF全文
![点击此处可从《Journal of oral pathology & medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
8.
Vax VV Bibi R Diaz-Cano S Gueorguiev M Kola B Borboli N Bressac-de Paillerets B Walker GJ Dedov II Grossman AB Korbonits M 《The Journal of endocrinology》2003,178(2):301-310
Cell cycle dysregulation is one of the defining features of cancer. Cyclin-dependent kinase 4 (CDK4), together with its regulatory subunit cyclin D, governs cell cycle progression through the G1 phase. Cyclin-dependent kinase inhibitors, including p16(INK4A) (encoded by CDKN2A), in turn regulate CDK4. In particular, dysregulation of the p16/CDK4/cyclin D complex has been established in a variety of types of human tumours. Dominant activating mutations affecting codon 24 of the CDK4 gene (replacement of Arg24 by Cys or His) render CDK4 insensitive to p16(INK4) inhibition and are responsible for melanoma susceptibility in some kindreds. However, 'knock-in' mice homozygous for the CDK4(R24C) mutation were noted to develop multiple neoplasia, most commonly including endocrine tumours: pituitary adenomas, insulinomas and Leydig cell testicular tumours. We therefore speculated that sporadic human endocrine tumours might also harbour such mutations. The aim of the current study was to analyze the CDK4 gene for the two characterized activating mutations, R24C and R24H, in sporadic human pituitary adenomas, insulinomas and Leydig cell tumours. We used DNA extracted from 61 pituitary adenomas, and paired tumorous and neighboring normal genomic DNA extracted from 14 insulinoma and 6 Leydig cell tumour samples. Genomic DNA from patients with familial melanoma harbouring the R24C or the R24H mutations served as positive controls. All samples were subjected to PCR, mutation-specific restriction digests and/or sequencing. Both methodologies failed to detect mutations at these two sites in any of the sporadic endocrine tumours including pituitary adenomas, benign or malignant insulinomas or Leydig cell tumours, while the positive controls showed the expected heterozygote patterns. Protein expression of CDK4 was demonstrated by immunohistochemistry and Western blotting in pituitary and pancreatic samples. These data suggest that the changes in the regulatory 'hot-spot' on the CDK4 gene, causing various endocrine tumours in CDK4(R24C/R24C )mice, are not a major factor in sporadic pituitary, insulin beta-cell or Leydig cell tumorigenesis. 相似文献
9.
Rehana Bibi Quanhao Shen Lingfei Wei Dandan Hao Naixu Li Jiancheng Zhou 《RSC advances》2018,8(4):2048
Metal–organic framework (MOFs) based composites have received more research interest for photocatalytic applications during recent years. In this work, a highly active, visible light photocatalyst BiOBr/UiO-66-NH2 hybrid composite was successfully prepared by introducing various amounts of UiO-66-NH2 with BiOBr through a co-precipitation method. The composites were applied for the photocatalytic degradation of RhB (rhodamine B) dye. The developed BiOBr/UiO-66-NH2 composites exhibited higher photocatalytic activity than the pristine material. In RhB degradation experiments the hybrid composite with 15 wt% of UiO-66-NH2 shows degradation efficiency conversion of 83% within two hours under visible light irradiation. The high photodegradation efficiency of BUN-15 could be ascribed to efficient interfacial charge transfer at the heterojunction and the synergistic effect between BiOBr/UiO-66-NH2. In addition, an active species trapping experiment confirmed that photo-generated hole+ and O2− radicals are the major species involved in RhB degradation under visible light.Metal–organic framework (MOFs) based composites have received more research interest for photocatalytic applications during recent years. 相似文献
10.
Guida Landouré Peng‐Peng Zhu Charles M. Lourenço Janel O. Johnson Camilo Toro Katherine V. Bricceno Carlo Rinaldi Katherine G. Meilleur Modibo Sangaré Oumarou Diallo Tyler M. Pierson Hiroyuki Ishiura Shoji Tsuji Nichole Hein John K. Fink Marion Stoll Garth Nicholson Michael A. Gonzalez Fiorella Speziani Alexandra Dürr Giovanni Stevanin Leslie G. Biesecker for the NIH Intramural Sequencing Center John Accardi Dennis M. D. Landis William A. Gahl Bryan J. Traynor Wilson Marques Jr Stephan Züchner Craig Blackstone Kenneth H. Fischbeck Barrington G. Burnett 《Human mutation》2013,34(10):1357-1360
We report here the genetic basis for a form of progressive hereditary spastic paraplegia (SPG43) previously described in two Malian sisters. Exome sequencing revealed a homozygous missense variant (c.187G>C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain iron accumulation (NBIA). The same mutation was subsequently also found in a Brazilian family with features of NBIA, and we identified another NBIA patient with a three‐nucleotide deletion (c.197_199del; p.Gly66del). Haplotype analysis revealed that the p.Ala63Pro mutations have a common origin, but MRI scans showed no brain iron deposition in the Malian SPG43 subjects. Heterologous expression of these SPG43 and NBIA variants resulted in similar alterations in the subcellular distribution of C19orf12. The SPG43 and NBIA variants reported here as well as the most common C19orf12 missense mutation reported in NBIA patients are found within a highly conserved, extended hydrophobic domain in C19orf12, underscoring the functional importance of this domain. 相似文献