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991.
The Effects of Two Different Anaesthesia Techniques on Bispectral Index Values and Awareness During Off-Pump Coronary Artery Bypass Grafting 总被引:2,自引:0,他引:2
Bestas A Yasar MA Bayar MK Inalkac S 《Journal of clinical monitoring and computing》2004,18(5-6):347-351
Objective. The aim of this study was to evaluate Bispectral Index values and awareness during two different anaesthesia regimens (fentanyl-propofol
and fentanyl-midazolam) in patients undergoing off-pump CABG surgery. Methods. Fifty patients were included in the study. Patients were premedicated with midazolam and were randomly divided into two
groups. Anaesthesia was induced with fentanyl (7–15 μg/kg), with either propofol (2–2.5 mg/kg, Group I) or midazolam (0.1–0.3
mg/kg, Group II) and vecuronium (0.1 mg/kg). Anaesthesia was maintained with fentanyl (15 μg/kg/h) together with either propofol
(6 mg/kg/h) or midazolam (0.1 mg/kg/h). Depth of anaesthesia was adjusted according to clinical signs and haemodynamic responses.
The level of sedation was monitored with Bispectral index continuously, but these levels were not shown to the attending anaesthetist.
Bispectral index values were recorded for nine phases. Twenty-four hours after the operation, the patients were interviewed
to determine intraoperative awareness and recall. Results. In all patients, Bispectral index values were found to decrease after induction (in Group I, p = 0.005, in Group II, p = 0.008) with the mean values remaining below 60 for all phases. The differences between the groups were not statistically
significant in inter-group comparison. No patients were noted to recall the sounds presented during the operation and the
preoperative events. Conclusions. BIS monitoring with clinical signs may be used to assess the adequacy of both types of anaesthesia techniques as well as
to detect awareness during off-pump CABG surgery. 相似文献
992.
Research has demonstrated that women report more pain than men, and clinical observations suggest that attenuated adrenocortical activity is associated with high pain sensitivity. The extent to which cortisol concentrations and hemodynamics contribute to gender differences in pain sensitivity has not been investigated. Thirty-four women and 31 men performed the hand cold pressor test (CPT). Participants rated their pain every 15 s during a 90-s CPT and a 90-s post-CPT recovery period and reported pain using the McGill Pain Questionnaire (MPQ). Salivary cortisol samples and cardiovascular measures were collected prior to, during, and after the CPT. Women reported greater pain than men during and after the CPT and on the MPQ (Ps<0.01). CPT disrupted the expected diurnal decline in cortisol, as shown by a significant increase in cortisol concentration post-CPT (P<0.01) in men and women. Regression analyses revealed that pre-CPT cortisol concentrations predicted lower pain reports during and after CPT in men only (P<0.01). Systolic blood pressure (BP) and stroke volume correlated negatively with pain reports only in women (Ps<0.05). Controlling for potential confounding variables did not alter these relationships. The negative association between pre-CPT cortisol and pain perception in men and the association between BP and pain in women demonstrate different physiological predictors of pain perception in men and women. 相似文献
993.
Yagmurca M Erdogan H Iraz M Songur A Ucar M Fadillioglu E 《Clinica chimica acta; international journal of clinical chemistry》2004,348(1-2):27-34
BACKGROUND: Nephrotoxicity is one of the important side effects of antracycline antibiotics. The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, against nephrotoxicity induced by doxorubicin (DXR). METHODS: The rats were divided into control, CAPE alone, doxorubicin (20 mg/kg, i.p.) and doxorubicin plus CAPE (10 micromol/kg/day, i.p.) groups. At the end of the 10th day, kidney tissues were removed for light microscopy and analysis. The levels of tissues protein carbonyl content (PC), malondialdehyde (MDA) and nitric oxide (NO) as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and myeloperoxidase (MPO) were determined. Plasma oxidants and antioxidants were also measured. RESULTS: The activities of CAT and GSH-Px were decreased as well as myeloperoxidase, NO, MDA and PC were increased in renal tissue of doxorubicin group compared with the other groups. Plasma GSH-Px activity was higher in doxorubicin plus CAPE group than the others and plasma MDA level was higher in doxorubicin group than the other groups. There were glomerular vacuolization, tubular desquamation, loss of brush border, and adhesion to Bowman's in the light microscopy in the kidneys of doxorubicin group. The tubules and brush border were almost normal and some of the glomerulus was filled with fine vacuoles in CAPE treated rats. CONCLUSION: Doxorubicin caused renal injury and CAPE treatment prevented lipid peroxidation and protein oxidation in renal tissue and partially preserved glomerulus and tubules. 相似文献
994.
995.
Ahmet Hilmi Kaya Adnan Dagcinar Mustafa Onur Ulu Arif Topal Yasar Bayri Aykan Ulus Cem Kopuz Bulent Sam 《Journal of clinical neuroscience》2010,17(1):80-84
The perforating branches of the P1 segment of the posterior cerebral artery are vulnerable to injury. Because of their close proximity to the basilar artery, the vulnerability occurs especially during surgical interventions for vascular pathologies such as basilar apex aneurysms. Therefore, extensive knowledge of the microsurgical anatomy of this area is mandatory to prevent poor post-operative outcomes. We microscopically examined 28 P1 segments obtained from 14 adult fresh cadaver brains (6 silicone injected, 8 freshly examined). The P1 segments ranged between 2.8 mm and 12.2 mm (mean 6.8 mm) in length with a mean outer diameter of 1.85 mm (range 0.8–4.5 mm). All 94 thalamoperforating branches identified in 27 P1 segments (mean 3.35 branches per segment) arose from the postero-superior aspect of P1 and were the most proximally originating branch in nearly all specimens (96.4%). In addition in 28 P1s, 12 short circumflex arteries (42.8%; mean 0.42 branches per segment), 16 long circumflex arteries (57.1%; mean 0.57 branches per segment) and 10 medial posterior choroidal arteries (35.7%; mean 0.35 branches per segment) were identified and all originated from the posterior or postero-inferior surface of the P1 segment. When the P1 segment had more than one type of branch, it was the short circumflex arteries that were always more proximal in origin than the others. The medial posterior choroidal arteries were always more distal in origin. All three branches were not observed together in any of the P1 segments. The findings in this, and future, anatomical studies may help to reduce the post-surgical morbidity and mortality rates after surgery for posterior circulation aneurysms. 相似文献
996.
997.
Necip Ermis Hakan Gullu Mustafa Caliskan Aydan Unsal Mustafa Kulaksizoglu Haldun Muderrisoglu 《Journal of diabetes and its complications》2010,24(4):229-233
PurposeDiabetic cardiac neuropathy, which is characterized by reduced heart rate variability (HRV), frequently coexists with peripheral neuropathy. Gabapentin has been used for the treatment of diabetic neuropathy. We aimed to evaluate the possible effect of gabapentin treatment on autonomic function in patients with type 2 diabetes via HRV.MethodsThirty patients with type 2 diabetes mellitus and peripheral neuropathy and 28 age- and sex-matched healthy controls were consecutively registered. Each patient underwent HRV measurements, and diabetic patients were administered gabapentin. After 3 months of gabapentin therapy, HRV parameters were measured again.ResultsBaseline HRV parameters were blunted in patients with diabetes mellitus according to the controls [standard deviation of all NN intervals (SDNN, ms): 106.3±29.9 vs. 148.8±36.5, P=.001; power spectrum of the high-frequency band (HF, ms2): 133.6±98.3 to 231.4±197.6, P=.02; power spectrum of the low-frequency band (LF, ms2): 341.8±247.8 to 511.5±409.4, P=.048; LF/HF ratio: 3.3±2.4 to 2.6±1.5, P=.33]. After 3 months of treatment with gabapentin, some HRV parameters showed some improvement. SDNN (106.2±29.8 to 119.4 ± 25, P=.016) and HF (133.6±98.3 to 167.6±118.3, P=.021) increased significantly. LF/HF ratio decreased (from 3.3±2.4 to 2.3±1.9, P=.039) and LF remained unchanged (341.8±247.8 to 352.3±228.9, P=.88).ConclusionsTherapeutic doses of gabapentin not only alleviate neuropathic symptoms but also improve cardiac autonomic function in diabetic patients with peripheral neuropathy. 相似文献
998.
Ayda Turkoz Aysu Kocum H. Evren Eker Hacer Ulgen Mustafa Uysalel Gulnaz Arslan 《Journal of anesthesia》2010,24(1):43-48
Purpose
We investigated whether inserting an intrathecal catheter and leaving it in place for 24 h after an unintentional dural puncture in orthopedic patients reduced the incidence of post-dural puncture headache (PDPH).Methods
The study consisted of 427 patients in whom a total of 21 unintentional dural punctures had occurred during orthopedic surgery performed between 2002 and 2006. Seven patients (phase I; evaluated retrospectively) each underwent placement of an epidural catheter at another level after dural puncture during the period January 2002 to February 2004. Fourteen patients (phase II; evaluated prospectively) received an epidural catheter through the dural tear after an unintentional dural puncture during the period February 2004–March 2006Results
In phase I, 5 of the 7 patients experienced PDPH, and one required an epidural blood patch. In phase II, only one of the 14 patients complained of PDPH, which resolved after 48 h of medical therapy. No patient experienced paresthesia, neurologic or hemorrhagic complication, or infection.Conclusion
Inserting an epidural catheter through the dural tear following an unintentional dural puncture and leaving it in place for 24 h significantly reduces the incidence of PDPH. 相似文献999.
Ibrahim Turkcuer Mustafa Serinken Ozgur Karcioglu Mehmet Zencir M. Kemal Keysan 《Urological research》2010,38(1):29-33
Acute severe colicky pain in the flank region is termed as renal colic (RC), which is commonly diagnosed and treated in the
emergency department (ED). The present study is designed to investigate the hospital costs of patients with RC admitted to
the ED and factors affecting the figures. Retrospective analysis includes all patients diagnosed with RC following physical
examination and X-ray, ultrasound, computed tomography together with laboratory investigations in the university-based ED
between February 2007 and February 2009. The study included 574 patients eligible for the predefined criteria. Mean total
hospital cost in patients admitted to the ED due to RC was calculated to be 55.77 Euro. The greatest contribution to the total
cost was made by radiological investigations in the ED (40.5%) followed by treatment costs (19.7%). Size and location of the
stone and stay times in the ED were the independent variables affecting the costs. The costs were higher as the stones were
bigger and as they were more distal in the ureter. Renal stones were associated with the lowest hospital costs. Radiological
investigations are the greatest contributors in the ED costs in patients with RC. Effective measures need to be undertaken
to reduce resultant costs. Preventive measures as well as diagnostic and therapeutic procedures should be standardized in
the ED in accordance with technological advances and also cost-effectiveness when appropriate. 相似文献
1000.
Tevfik Aktoz Meryem Aktoz Ersan Tatlı Mustafa Kaplan Fatma N. Turan Ahmet Barutcu Irfan H. Atakan Muzaffer Demir Armagan Altun 《International urology and nephrology》2010,42(4):873-879
The plasma concentration of asymmetrical dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, has been linked to
endothelial dysfunction. We investigated the relation between plasma ADMA concentration and severity of erectile dysfunction
(ED) and coronary artery disease (CAD). We measured plasma levels of ADMA in 92 male patients. Patients were divided into
three groups: group 1 (n = 41), patients with ED and without CAD; group 2 (n = 29), patients with stable CAD; group 3 (n = 22), control group (patients without CAD or ED). Erectile function was evaluated by the erectile function domain of the
international index of erectile function (IIEF-EFD) a validated 15-item self-administered questionnaire. Erectile function
is specifically addressed by six questions that form the so-called erectile function domain of the questionnaire. Each question
is scored 0–5. ED is defined as any value <26. Patients with CAD who have stable angina pectoris were selected after coronary
angiography. ADMA was analyzed by ELISA method. Group 1 had significantly higher concentrations of plasma ADMA than groups
2 and 3 (respectively, 0.75 ± 0.40 vs. 0.50 ± 0.30, P = 0.013; 0.75 ± 0.40 vs. 0.50 ± 0.25, P = 0.021). There was negative correlation between ADMA and IIEF-EFD score in all groups (n = 92) (r = −0.322, P = 0.002). In a multiple logistic regression analysis adjusting for age, hyperlipidemia, ADMA remained independent predictor
for severe ED. Odds ratio for plasma ADMA was 14.151 (1.101–181.940; P = 0.042). First of all, this study provides that ADMA concentrations are significantly higher in patients who have ED when
compared to patients with CAD and controls. Second, there was a negative correlation between ADMA and severity of ED. Elevating
levels of circulating ADMA is an independent risk factor for severe of ED, and ADMA may be a link between CAD and ED. 相似文献