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101.
目的探讨一种简单、微创、经济的腔镜方法治疗自发性气胸。 方法收集2011年10月至2016年2月胸腔镜手术治疗自发性气胸84例,其中两孔胸腔镜肺大疱结扎54例(试验组),三孔胸腔镜肺大疱切割缝合器楔形切除30例(对照组)。试验组,根据胸壁不同厚度把肺大疱拉近操作孔或拉至操作孔或拉出操作孔用手直接结扎/缝扎后做机械摩擦的胸膜固定术;对照组按常规进行,用切割缝合器行肺楔形切后做机械摩擦的胸膜固定术。 结果两组患者的临床效果差异无统计学意义(P>0.05),试验组的住院费用低于对照组[(16 747.30±2 586.41) 元 vs (21 088.54±6 005.68)元,P<0.05]。 结论两孔胸腔镜下肺大疱用手缝扎/结扎技术治疗自发性气胸简单、微创、经济。  相似文献   
102.
目的总结分析原位背驮式肝移植手术后并发症与供肝修整的关系。方法回顾性分析我院12例行原位背驮式同种异体肝移植患者的资料。结果本组12例肝移植围手术期无死亡;手术成功率为100%。12例中行动脉血管变异整形2例.门静脉搭桥吻合1例;各韧带修剪后缝合7例.未缝合5例。手术后发生腹腔内出血3例,其中2例与供肝修整有关,即修肝时各韧带未仔细缝合及结扎而导致细小血管出血,另1例系凝血功能障碍所致;在供肝修整中注意了血管的变异整形及胆管的血供.术后无动脉及门静脉血管并发症和胆道并发症发生。结论修肝质量的好坏,直接关系到术中植肝时手术操作的难度、术后供肝的存活质量、并发症的发生和患者的康复。  相似文献   
103.
Inflammatory myofibroblastic tumor of the carina and the main bronchus is a rare tumor. The authors report here on a case of a 4-year-old boy with an inflammatory myofibroblastic tumor at the carina and extending to the left main bronchus. He presented with fever and a cough of 2 months' duration. Preoperative assessment of the tumor revealed an intraluminal round mass arising from the carina and extending into the left main bronchus, and this caused near-total obstruction of the left main bronchus and the subsequent total collapse of the entire left lung. The complete resection of the mass with carinal reconstruction was successful. The tumor was a round mass measuring 1.5 × 1 cm. It had characteristic features of an inflammatory myofibroblastic tumor, namely, the proliferation of spindle-shaped fibroblasts and myofibroblasts.  相似文献   
104.
Ovariectomy induces deterioration of the trabecular structure in the femoral neck of ewes, as depicted by MR microscopic imaging. This structural deterioration is prevented by salmon calcitonin treatment. INTRODUCTION: This study evaluated the trabecular (Tb) microarchitecture of an ovariectomy (OVX)-induced osteoporotic model in ewes and determined the effects of salmon calcitonin (sCT), an osteoclast inhibitor, on the Tb structure. This is the first report of OVX-induced changes in the Tb structure in the femoral neck in the ewes and effect of sCT on the microarchitecture. MATERIALS AND METHODS: Ewes (5-8 years old, n = 28) were equally allocated into sham (Sham), OVX injected with vehicle, or OVX injected with sCT at 50 or 100 IU, three injections per week. They were killed 6 months after OVX. The femoral neck was examined with an MR imager at 9.4 T in axial, coronal, and sagittal planes. An internal calibration procedure as a means of standardizing image analysis was used to adjust the segmentation threshold. Data from all three planes were averaged. RESULTS AND CONCLUSIONS: Compared with Sham, OVX induced significant changes (p < 0.0125) in the MRI-derived femoral neck Tb structure: Tb bone volume fraction (BV/TV), -18%; Tb number, -20%; Tb separation, +23%; number of free ends, +28%; number of nodes, -39%; number of Tb branches, -23%; mean length of Tb branches, -19%. Compared with OVX, treatment of sCT at 100 IU significantly improved all the Tb structural parameters to the Sham level (p < 0.0001 approximately p = 0.0281), whereas 50 IU significantly increased the Tb number and the mean length of the Tb branches. BV/TV explained 74% of the variation of compressive stress of the trabecular cylinder cores of the femoral neck. Combining all structural parameters in a multivariate regression analysis significantly improved the explanation to 84%, and adding BMD further improved the predictive ability of the model to 92%. We conclude that OVX induces deterioration of the MRI-derived Tb microstructure in the femoral neck of ewes. sCT treatment prevents OVX-induced changes. The femoral neck microarchitecture significantly correlates with its biomechanical properties. Combining microstructural parameters with BMD further improves the prediction of bone biomechanical properties. The effects of sCT on OVX ewes may help explain reduced fracture risk in postmenopausal osteoporotic women treated with sCT.  相似文献   
105.
BACKGROUND: Patients with advanced cervical metastases from mucosal squamous cell carcinoma have a poor prognosis because of their high risk of regional and distal failure. This study aims to evaluate the outcomes of patients with clinical N2 or N3 disease managed with surgery and postoperative radiotherapy. METHODS: From a comprehensive computerized database, 181 entered patients who had neck dissection for N2 or N3 disease between 1988 and 1999 were evaluated. The mean age was 62 years, and minimum follow-up was 3 years. RESULTS: A total of 233 neck dissections were performed in 181 patients, including 163 comprehensive and 70 selective dissections. Postoperative radiotherapy was given in 82% of cases. The local control rate was 75% at 5 years, and control of disease in the treated neck was achieved in 86%. Macroscopic extracapsular spread (ECS) significantly increased regional recurrence (p = .001). Adjuvant radiotherapy significantly improved neck control (p = .004) but did not alter survival. Patients with ECS (both microscopic and macroscopic) who received radiotherapy had a significantly better survival than did patients with ECS who did not receive radiotherapy. Disease-specific survival for the entire group was 39% at 5 years. By use of multivariate analysis, macroscopic ECS and N2c neck disease were independent adverse prognostic factors for survival (p = .001). CONCLUSIONS: Despite a high rate of control in the treated neck, the poor survival (39%) in this patient group indicates that adjuvant therapeutic strategies need to be considered.  相似文献   
106.
通过系统梳理涉及伦理委员会建设的现行立法,从法律角度探讨伦理委员会的法律地位、人员组成、资质考核、操作规程、法律监督等方面存在的问题。通过剖析存在的问题,建议提高立法等级,确定性别比例和专业占比标准,参考美国伦理委员会专业认证制度加强委员资质考核;建立专门操作指南,强调跟踪审查;适当调整各方监管权限,下设专门监管机构。  相似文献   
107.
目的 探讨老年急性心肌梗死(AMI)患者血清γ-干扰素(IFN-γ)的水平含量与发病关系.方法 采用酶联免疫吸附法(ELISA)分别测定34例老年AMI患者、38例老年稳定型心绞痛(SA)患者及39例老年对照组(NC)的血清IFN-γ水平.结果 NC组与SA组比较IFN-γ含量差异无统计学意义(P>0.05),而AMI组IFN-γ含量低于NC组及SA组,差异有统计学意义(P<0.001).结论 老年AMI患者 IFN-γ水平降低,机体免疫调节失衡,可能对老年AMI的形成和发展产生影响.IFN-γ水平可作为老年AMI严重程度的监测指标.  相似文献   
108.
目的:探索类固醇分泌功能的肾上腺皮质三维培养体系.方法:选取2019—2021年于广西医科大学第二附属医院的流产胚胎肾上腺组织,消化成细胞悬液,基质胶包裹三维培养.培养基中添加FGF2生长因子,Wnt信号通路激活因子(CHIR99021、R-spondin1),通过病理组织染色、实时荧光定量逆转录聚合酶链反应(RT-q...  相似文献   
109.
目的:观察疏肝和胃丸抑制大鼠胃酸、胃蛋白酶分泌的作用。方法:将40只大鼠随机分为对照组、模型组、胃苏冲剂组、疏肝和胃丸组,每组10只。末次灌胃后,除对照组外的大鼠均采用幽门结扎法复制大鼠胃溃疡模型,观察各组大鼠胃酸、胃蛋白酶分泌的变化。结果:疏肝和胃丸组大鼠胃酸、胃蛋白酶的分泌水平明显降低,与模型组、胃苏冲剂组比较均有显著差异(P<0.05)。结论:疏肝和胃丸具有显著抑制胃酸、胃蛋白酶分泌的作用。  相似文献   
110.
目的:观察益肾通络方对实验性肾病综合征大鼠肾功能的保护作用。方法:采用尾静脉注射阳离子化牛血清白蛋白造模。将40只雄性SD大鼠随机分为模型组、益肾通络方组、肾炎四味片组、正常对照组,每组10只。造模后予以药物干预,共给药4w。采用化学比色法检测24h尿蛋白,光镜下切取肾组织进行病理形态学观察。结果:与模型组比较,肾炎四味片组和益肾通络方组大鼠24h尿蛋白量明显降低(P<0.01);而2组之间比较,益肾通络方组大鼠24h尿蛋白量降低更显著(P<0.01)。病理形态学观察:模型组肾小球呈局灶性节段性硬化,肾小管上皮细胞水肿,部分小管腔内可见蛋白管型,肾间质纤维化;肾炎四味片组以上改变较同期模型组轻,而益肾通络方组显著减轻。结论:益肾通络方能降低大鼠尿蛋白,保护肾功能。  相似文献   
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