Synthesis,structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

The synthesis of 1-N and 3-N aminoalkyl derivatives of 5,5-diphenylhydantoin is described. Structural elucidation based on X-ray analysis was performed for two representative compounds 4a and 9b. The effect of tested compounds on the electrocardiogram was examined in vitro in the non-working heart perfusion test and antiarrhythmic activity in the rat coronary artery ligation-reperfusion model. The most active 1-N derivatives 4a and 7b have shown properties of the compounds belonging to class Ia, according to the Vaughan Williams classification. The spatial organisation of the chosen compounds necessary for their pharmacological activity was discussed.