Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.     

Identification of Boseongicola sediminum sp. nov., a Novel Decabromodiphenyl Ether (BDE-209)-tolerant Strain Isolated from Coastal Sediment in Xiamen,China

Polybrominated diphenyl ethers (PBDEs) are a group of aromatic organic bromine compounds, which have been used in a broad array of polymeric materials (plastics, foams, resins, and adhesives) as brominated flame retardants. They are used in commercial and household products, including textiles, electronic equipment, airplanes, and automobiles, especially in China and the USA, because they are inexpensive with excellent flame-retardant effects[1]. During the past decade, over 14,000 tonnes of PBDEs have entered the market, and have become ubiquitous environmental contaminants[2].     

Effect of Focused Cardiac Ultrasound in Combination with Lung Ultrasound on Critically Ill Patients:A Multicenter Observational Study in China

Objective Focused cardiac ultrasound (FCU) and lung ultrasound (LU) are increasingly being used in critically ill patients.This study aimed to investigate the effect of FCU in combination with LU on these patients and to determine if the timing of ultrasound examination was associated with treatment change.Methods This is a multicenter cross-sectional observational study.Consecutive patients admitted to the intensive care unit (ICU) were screened for enrollment.FCU and LU were performed within the first 24 h,and treatment change was proposed by the performer based on the ultrasound results and other clinical conditions.Results Among the 992 patients included,502 were examined within 6 h of ICU admission (early phase group),and 490 were examined after 6 h of admission (later phase group).The early phase group and the later phase group had similar proportions of treatment change (48.8％ vs.49.0 ％,x2 =0.003,P=0.956).In the multivariable analysis,admission for respiratory failure was an independent variable associated with treatment change,with an odds ratio (OR) of 2.357[95 ％ confidence interval (CI):1.284-4.326,P=0.006];the timing of examination was not associated with treatment change (OR=0.725,95％CI:0.407-1.291,P=0.275).Conclusions FCU in combination with LU,whether performed during the early phase or later phase,had a significant impact on the treatment of critically ill patients.Patients with respiratory failure were more likely to experience treatment change after the ultrasound examination.     

MTHFR基因多态性与老年精神分裂症患者共患冠心病的关系及其对精准护理的启示

目的 初步探讨MTHFR基因多态性与老年精神分裂症患者共患冠心病的关系,并讨论其对精神分裂症患者精准护理的启示.方法 选取2019年1月至2020年1月本院收治的精神分裂症患者126例作为研究对象,使用自行设计的病例资料收集表收集研究对象的病史资料及心肌酶谱、心电图、心脏彩超、MTHFR基因型等相关检查.结果 不同MTHFR基因型的老年精神分裂症患者的冠心病发病率比较差异无统计学意义;与未合并冠心病的精神分裂症患者相比,精神分裂症拟诊冠心病者在"单药治疗"比例较低、在"双药联合治疗""三药联合治疗"和"接受氯氮平治疗"的比例较高.结论 精神分裂症共患冠心病可能与MTHFR基因多态性无关,而与抗精神病药物治疗方案有关,提示适用于一般人群的精准护理策略不能简单套用于精神分裂症患者,其精准护理应有自己的方向和道路.     

一体化血管通路团队管理对人工血管移植动静脉内瘘的作用

目的：探讨一体化血管通路团队管理人工血管移植动静脉内瘘（AVG）的效果。方法：以2017年1月至2018年12月期间温州医科大学附属第二医院收治的106例行连续AVG成功的血液透析患者为研究对象。应用随机数字表法将其分为对照组54例和研究组52例。对照组给予常规的血管通路管理,研究组纳入血管通路团队的管理。对参与者进行前瞻性随访,观察内瘘成熟和通路通畅情况。AVG通畅率估算应用Kaplan-Meier法,生存曲线之间的比较采用Log-Rank检验。结果：对照组初级内瘘成熟率为77.8%（42/54）,研究组初级内瘘成熟率为92.3%（48/52）,差异有统计学意义（χ2=4.364,P=0.037）。对照组1年累积初级通畅率为52.7%,研究组1年累积初级通畅率为63.9%,2组之间的初级通畅生存曲线存在显著差异（χ2=4.071,P=0.044）。结论：实施一体化血管通路团队管理能够提升AVG内瘘成熟率和通畅率,具有一定的临床实践意义。