全文获取类型
收费全文 | 10606篇 |
免费 | 481篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 98篇 |
儿科学 | 233篇 |
妇产科学 | 82篇 |
基础医学 | 1402篇 |
口腔科学 | 227篇 |
临床医学 | 627篇 |
内科学 | 2828篇 |
皮肤病学 | 129篇 |
神经病学 | 698篇 |
特种医学 | 376篇 |
外科学 | 2006篇 |
综合类 | 61篇 |
预防医学 | 266篇 |
眼科学 | 187篇 |
药学 | 529篇 |
中国医学 | 49篇 |
肿瘤学 | 1366篇 |
出版年
2024年 | 10篇 |
2023年 | 93篇 |
2022年 | 173篇 |
2021年 | 279篇 |
2020年 | 144篇 |
2019年 | 189篇 |
2018年 | 257篇 |
2017年 | 183篇 |
2016年 | 267篇 |
2015年 | 221篇 |
2014年 | 332篇 |
2013年 | 385篇 |
2012年 | 692篇 |
2011年 | 711篇 |
2010年 | 434篇 |
2009年 | 351篇 |
2008年 | 686篇 |
2007年 | 722篇 |
2006年 | 700篇 |
2005年 | 732篇 |
2004年 | 676篇 |
2003年 | 628篇 |
2002年 | 663篇 |
2001年 | 112篇 |
2000年 | 92篇 |
1999年 | 117篇 |
1998年 | 175篇 |
1997年 | 140篇 |
1996年 | 111篇 |
1995年 | 108篇 |
1994年 | 88篇 |
1993年 | 90篇 |
1992年 | 62篇 |
1991年 | 69篇 |
1990年 | 46篇 |
1989年 | 53篇 |
1988年 | 58篇 |
1987年 | 49篇 |
1986年 | 29篇 |
1985年 | 23篇 |
1984年 | 30篇 |
1983年 | 26篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1980年 | 22篇 |
1979年 | 7篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1970年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
911.
Narumi Tokaji Hiromichi Ito Tomohiro Kohmoto Takuya Naruto Rizu Takahashi Aya Goji Tatsuo Mori Yoshihiro Toda Masako Saito Shoichiro Tange Kiyoshi Masuda Shoji Kagami Issei Imoto 《American journal of medical genetics. Part A》2018,176(3):699-702
912.
Tange Yoshihiro Yoshitake Shigenori Takesawa Shingo 《Journal of artificial organs》2018,21(3):392-395
Journal of Artificial Organs - Intravenous oxygenation has demonstrated significant increase in partial pressure of oxygen (PO2) in animal models. A highly dissolved oxygen solution might be able... 相似文献
913.
Identification of miR‐305, a microRNA that promotes aging,and its target mRNAs in Drosophila
下载免费PDF全文
![点击此处可从《Genes to cells : devoted to molecular & cellular mechanisms》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Makiko Ueda Tetsuya Sato Yasuyuki Ohkawa Yoshihiro H. Inoue 《Genes to cells : devoted to molecular & cellular mechanisms》2018,23(2):80-93
MicroRNAs (miRNAs) are involved in the regulation of important biological processes. Here, we describe a novel Drosophila miRNAs involved in aging. We selected eight Drosophila miRNAs, displaying high homology with seed sequences of aging‐related miRNAs characterized in other species, and investigated whether the over‐expression of these miRNAs affected aging in Drosophila adult flies. The lifespan of adults over‐expressing miR‐305, a miRNA showing high homology with miR‐239 in C. elegans, was significantly shorter. Conversely, a reduction in miR‐305 expression led to a longer lifespan than that in control flies. miR‐305 over‐expression accelerated the impairment of locomotor activity and promoted the age‐dependent accumulation of poly‐ubiquitinated protein aggregates in the muscle, as flies aged. Thus, we show that the ectopic expression of miR‐305 has a deleterious effect on aging in Drosophila. To identify the targets of miR‐305, we performed RNA‐Seq. We discovered several mRNAs encoding antimicrobial peptides and insulin‐like peptides, whose expression changed in adults upon miR‐305 over‐expression. We further confirmed, by qRT‐PCR, that miR‐305 over‐expression significantly decreases the mRNA levels of four antimicrobial peptides. As these mRNAs contain multiple sequences matching the seed sequence of miR‐305, we speculate that a reduction in target mRNA levels, caused by ectopic miRNA expression, promotes aging. 相似文献
914.
We studied the clinical characteristics of nine patients with pulmonary Mycobacterium avium complex disease occurring in association with corticosteroid drugs collected from our associated hospitals during the past
6 years. The average age of the nine patients was 62.2 years and the male/female ratio was 3 : 6. Regarding underlying disease,
respiratory diseases existed in four of the patients and nonrespiratory diseases in the other five patients. The duration
of corticosteroid treatment ranged from 5 months to 5 years, and the total dose of corticosteroid drugs ranged from 1.78 to
43.20 g. Pulmonary Mycobacterium avium complex disease was detected by clinical symptoms during corticosteroid treatment in six patients, and purified protein derivative
was positive in three of eight patients tested. Radiological findings showed an infiltration shadow without cavity and bronchiectasis
in the lower lung field. Microbiological examination was smear-positive in three patients, and the isolated mycobacterium
was Mycobacterium intracellulare in five patients and Mycobacterium avium in four. Tolerance was shown to all antituberculous drugs, except for clarithromycin, in all patients. Although treatment
including clarithromycin was performed for seven patients, the sputum conversion rate was 33% and an improved clinical effect
was noted in only one patient. No change occurred in four and worsening occurred in four. Attention should be paid to the
clinical symptoms and radiological findings of patients who have received corticosteroid drugs over a long period of time,
because pulmonary Mycobacterium avium complex is characterized by atypical radiographic findings with no relationship to the total dose or duration of the administered
corticosteroid drugs.
Received: August 22, 2002 / Accepted: October 21, 2002 相似文献
915.
Yoshihiro Tanaka Tsuyoshi Yoshimuta Keiichi Kimura Kenji Iino Yudai Tamura Kenji Sakata Kenshi Hayashi Hirofumi Takemura Masakazu Yamagishi Masa-aki Kawashiri 《Journal of vascular surgery》2018,67(4):1127-1133
Objective
Spontaneous isolated visceral artery dissection (SIVAD) involving the celiac artery or superior mesenteric artery is rare, but it can be fatal. Given its rare incidence, the clinical characteristics of SIVAD are not fully understood. Therefore, the aim of this study was to investigate the clinical characteristics and prognosis of SIVAD.Methods
We retrospectively reviewed 39 consecutive patients diagnosed with SIVAD from January 2007 to December 2016. Demographic characteristics, symptoms, vital signs, blood examination results, and computed tomography findings were retrieved through medical record review.Results
The median age of the patients was 52 years; 94.9% were male, and 64.1% were symptomatic. Median follow-up duration was 11 months. Overall, hypertension (48.7%) and smoking (79.5%) were frequently observed. There were significant differences between symptomatic and asymptomatic patients in white blood cell count and creatine kinase level but not in fibrin degradation products or D-dimer level. There was a significant correlation between symptoms and length of dissection on computed tomography (P < .01). Conservative treatment was performed in 32 patients (82.1%), and only 7 patients required open surgery or intravascular intervention. Notably, the diameter of affected vessels decreased spontaneously with no rupture or symptom recurrence during follow-up, and mortality was 0% at both 30 days and 1 year.Conclusions
The utility of blood examination, especially for fibrin degradation products and D-dimer levels, for diagnosis of SIVAD is limited. A high index of suspicion is warranted in patients presenting with persistent severe abdominal pain. Conservative treatment should be considered first-line therapy in patients without any signs of bowel ischemia or rupture. 相似文献916.
Clinical diagnosis and treatment outcomes for parapharyngeal space schwannomas: A single‐institution review of 21 cases
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
917.
Yamanoi T Shibano K Soeda T Hoshi A Matsuura Y Sugiura Y Endo K Yamamoto T 《The Tohoku journal of experimental medicine》2004,203(2):133-139
We report three cases of intracranial aspergillosis originating in the sphenoid sinus in immunocompetent patients. The patients presented with an orbital apex syndrome in that a unilateral loss of vision and cranial nerve III palsy were seen in all cases and a contralateral involvement was also seen in one case. Despite the initial treatment with a conventional dose of itraconazole (ITCZ, 200 mg/day), the neurological deficits failed to improve and the granulomatous inflammation was not suppressed. Therefore, we treated with a combination of a high dose of ITCZ at 500-1000 mg/day (16-24 mg/kg/day) and amphotericin B (AMPH-B) at 0.5 mg/kg/day, in conjunction with a pulse dose of methylprednisolone at 1000 mg/day. Two cases responded favorably in that the ocular movements completely recovered, and their maximum serum concentrations of the hydroxy ITCZ were 7816 ng/ml and 5370 ng/ml. However, the other case worsened, despite ITCZ treatment at 16 mg/kg/day, and the serum concentration of the hydroxy ITCZ was 3863 ng/ml. The surgical decompression of the cavernous sinus via an extradural approach was performed, and the dose of ITCZ was increased to 24 mg/kg/day. The resulting serum concentration of the hydroxy ITCZ was 4753 ng/ml, and the outcome of this case has been favorable. These results suggest that a high blood level of the hydroxy ITCZ (more than 4500 ng/ml) is a prerequisite for the successful treatment of intracranial aspergillosis and that the combination treatment of ITCZ with AMPH-B would be preferred. The concomitant use of steroid and/or surgical decompression should be considered, if the invasiveness is not well-controlled in spite of intensive medical therapy. 相似文献
918.
Fukuda Y Yoshida K Ezaki H Tomita T Kosaka T Hori K Shimoyama T 《Nihon rinsho. Japanese journal of clinical medicine》2002,60(8):1543-1548
Peptic ulcer in elderly patients may be associated with Helicobacter pylori infection. Diagnosis for H. pylori infection should be needed in these patients. The test may be resulted in false negative in case of invasive diagnostic methods based gastric biopsy, because atrophic gastritis and intestinal metaplasia developed in patients may not be able to detect scarce infection of the bacterium. Urea breath test or stool antigen test are recommended for diagnosis of H. pylori infection in patients. It is suitable for patients, because of the non invasive nature of these diagnostic tests. 相似文献
919.