全文获取类型
收费全文 | 14223篇 |
免费 | 1427篇 |
国内免费 | 1092篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 175篇 |
妇产科学 | 130篇 |
基础医学 | 1578篇 |
口腔科学 | 326篇 |
临床医学 | 1885篇 |
内科学 | 2248篇 |
皮肤病学 | 154篇 |
神经病学 | 810篇 |
特种医学 | 499篇 |
外国民族医学 | 5篇 |
外科学 | 1615篇 |
综合类 | 2405篇 |
现状与发展 | 4篇 |
一般理论 | 1篇 |
预防医学 | 974篇 |
眼科学 | 418篇 |
药学 | 1407篇 |
1篇 | |
中国医学 | 677篇 |
肿瘤学 | 1361篇 |
出版年
2024年 | 39篇 |
2023年 | 241篇 |
2022年 | 565篇 |
2021年 | 725篇 |
2020年 | 571篇 |
2019年 | 501篇 |
2018年 | 536篇 |
2017年 | 424篇 |
2016年 | 439篇 |
2015年 | 655篇 |
2014年 | 778篇 |
2013年 | 667篇 |
2012年 | 968篇 |
2011年 | 1119篇 |
2010年 | 726篇 |
2009年 | 544篇 |
2008年 | 740篇 |
2007年 | 711篇 |
2006年 | 641篇 |
2005年 | 665篇 |
2004年 | 532篇 |
2003年 | 510篇 |
2002年 | 459篇 |
2001年 | 390篇 |
2000年 | 378篇 |
1999年 | 383篇 |
1998年 | 278篇 |
1997年 | 236篇 |
1996年 | 162篇 |
1995年 | 166篇 |
1994年 | 101篇 |
1993年 | 93篇 |
1992年 | 126篇 |
1991年 | 96篇 |
1990年 | 108篇 |
1989年 | 74篇 |
1988年 | 76篇 |
1987年 | 69篇 |
1986年 | 63篇 |
1985年 | 46篇 |
1984年 | 40篇 |
1983年 | 8篇 |
1982年 | 13篇 |
1981年 | 13篇 |
1980年 | 9篇 |
1979年 | 9篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 5篇 |
1966年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
122.
目的:研究安乃近溶液弄粘膜吸收规律。方法:以大鼠在体鼻循环法为实验模型,考察循环液的体积、流速等对安乃近弃枯膜吸收的影响。并在体积、流速确定的条件下,考查循环液浓度不同时,安乃近鼻粘膜吸收规律。结果:循环液体积越大,单位时间内粘膜吸收百分率越小;当流速较小时,随着流速的增加,吸收速度常数K增大,流速超过2 . 0 ml · min-1后,K显著减小;以循环液体积为3 ml,流速2.0 ml"min-1,考察了50,100,150,200 g·L-1安乃近溶液弄粘膜吸收规律,表明不同浓度的安乃近鼻粘膜吸收速度为一常数。结论:安乃近溶液鼻粘膜吸收机制为被动扩散,吸收符合一级动力学,吸收速度常数K为0.022 19 min-1 。 相似文献
123.
检测60例中、重度学龄期单纯性肥胖儿童的血液流变学指标,以M超、B超、多普勒血流显像、多普勒组织显像等技术对心功能状况进行了全面检查。结果表明,与正常体重对照组相比,肥胖儿血液流变学各指标均有显著变化(P均<0001),心脏的收缩和舒张功能均受累,血粘度的增加与心功能减低有明显的相关性。提示儿童期的单纯性肥胖已出现了血液流变学特性和心血管功能的异常,随着血粘度的增加,心功能渐减低,血液流变学特性的改变是单纯性肥胖症心血管系统功能受累的病理基础之一。 相似文献
124.
毛会 《武汉大学学报(医学版)》1999,20(3):247-248
对258例不孕症患者利用腹腔镜检查诊断不孕原因,明确病因后进行针对性治疗,并追踪随访术后妊娠率,妊娠结局。结果258例中95例为输卵管炎,术后妊娠42例,妊娠率4421%,84例子宫内膜异位症,术后妊娠62例,妊娠率7381%,61例多囊卵巢综合征,术后妊娠27例,妊娠率4436%。结果表明:腹腔镜检查能迅速,正确地诊断不孕原因,术后针对病因治疗,提高了不孕症患者的妊娠率。 相似文献
125.
观察机械性损伤的海马神经细胞在不同浓度高晶体- 高胶体渗透压溶液中容积的变化。取原代培养大白鼠胚胎的海马神经细胞,用超声波机械损伤细胞后暴露于含0.5 g/L、1 g/L和2.5 g/L氯化钠的细胞培养基中15 m in。结果显示机械性损伤的细胞明显肿胀(P< 0.05)。当细胞暴露于不同浓度的高晶体- 高胶体溶液15 m in 后, 细胞容积与同一实验时间的对照值相比明显下降, 并保持至第7 d (P< 0.05)。表明受到机械性损伤的海马神经细胞在高晶体- 高胶体渗透压环境中的容积调节功能丧失或减弱。 相似文献
126.
热休克蛋白70抑制大鼠感染性脑水肿炎症因子的研究 总被引:1,自引:1,他引:0
为了探讨热休克蛋白70(HSP70)对大鼠感染性脑水肿的保护作用,该文采用百日咳菌液所致的大鼠感染性脑水肿模型及将大鼠进行热休克处理,观察脑组织中白细胞介素1-β(IL-1β)、肿瘤坏死因子-α(TNF-α)及一氧化氮(NO)水平的变化,并应用Western印迹分析检测大鼠脑组织的HSP70表达。结果发现感染性脑水肿脑组织IL-1β、TNF-α及NO浓度均增高,热休克处理可降低以上三者的浓度,We 相似文献
127.
Yang GY Mao Y Zhou LF Gong C Ge HL Betz AL 《Brain research. Molecular brain research》1999,65(2):143-150
Our previous studies have demonstrated that overexpression of recombinant human interleukin-1 receptor antagonist protein (IL-1ra) via gene transfer can reduce ischemic brain injury. However, the mechanism of action of IL-1ra in ischemia is unclear. Since interleukin-1 can up-regulate intercellular adhesion molecules in endothelium, the present study was designed to determine whether overexpression of the IL-1ra can reduce the expression of intercellular adhesion molecule-1 (ICAM-1) after ischemic injury. Normal saline or adenovirus vector (1x109 particles) encoding the human IL-1ra gene (Ad.RSVIL-1ra) or the Escherichia coli LacZ gene (Ad.RSVlacZ) was injected into the right lateral cerebral ventricle of adult CD-1 mice. After five days, permanent middle cerebral artery occlusion (MCAO) was achieved for 24 h using an intraluminal suture. Cerebral blood flow was monitored by transcranial laser Doppler flowmetry to verify the occlusion. ICAM-1 protein was quantified using Western blot analysis and localized using immunohistochemistry. After MCAO, surface blood flow in the ischemic hemisphere was decreased to 9-11% of the baseline. There were fewer ICAM-1 positive vessels in the ischemic cortex of the Ad.RSVIL-1ra transfected mice than in the Ad.RSVlacZ transfected and saline treated mice (138+/-19 vs. 249+/-25, 284+/-22, p<0.05). Western blot analysis shows that ICAM-1 protein decreased 50-60% in the Ad. RSVIL-1ra group compared to the other two groups. There were no significant differences in the numbers of positive vessels in the ischemic basal ganglia and contralateral hemisphere among the three groups. Our studies suggest that IL-1ra overexpression can down-regulate the expression of ICAM-1 in the ipsilateral cortex in ischemic mice. Interleukin-1 may play an important role in the activation of inflammatory reaction during focal cerebral ischemia by promoting leukocyte adhesion on the endothelium cells. 相似文献
128.
Yoo CH Wang Y Ha J Mao L Kim S Tarin T Wolf P Youngkin TP Brems JJ Gittes RF D'Silva M Lee S 《Microsurgery》1999,19(2):78-82
Previous studies have suggested that hepatic arterial flow in heterotopic partial liver transplants is necessary to ensure graft survival and regenerative capacity. This report presents findings in a syngeneic rat strain (Lewis) that partial liver transplants can be successfully heterotopically transplanted in the long term with the only inflow coming from the portal vein. When the host liver undergoes a nearly complete resection at 3-4 weeks, the transplanted liver regenerates to maintain the health of the host. Moderate to massive hepatocellular necrosis occurs in the first 3 months postoperatively, with recovery by 4-5 months. Liver transplants 8-10 months postoperatively appear architecturally normal. No host liver tissues were found to be regenerating after subtotal host liver resection. We conclude that portal vein reconstruction without hepatic arterial inflow can sustain a partial liver transplant in the long term, replacing the function of the host liver. 相似文献
129.
Lee S Wang Y Mao L Cho C Kim S Tarin T Kim DH Mazzoni G Fazi M Nozawa M Lee D Sileshi B Wei W Lentini A Yoo CH Youngkin T Wolf P D'Silva M Gittes RF 《Microsurgery》1999,19(2):83-88
This periodic report includes intermittent results of consecutive pancreaticoduodenal (Pd) and kidney (Kt) transplants in inbred rats and results on double kidney transplants that did not follow sequential transplant protocol. Eight 24-month-old Lewis pancreas, kidney, and aorta served histological controls showing normal histological architecture with no atherosclerosis developed in the aorta. Thirty-four month old pancreas and thirty-two month old kidneys, which resided in young hosts for at least three occasions, appeared as youthful Pd and Kt grafts. They show normal histological appearance for more than the expected life span of a Lewis rat. The fact that not only pancreases but also kidneys outlived their host leads to the study of other different organs' viability as aged valuable grafts. Nevertheless, the threats by the development of atherosclerosis in graft-associated aortas resulted in slow progression of the follow-ups. 相似文献
130.
A ligand epitope antigen presentation system (LEAPS) heteroconjugate vaccine containing a CTL epitope (H1) from the HSV-1 immediate early protein ICP27 (322-332) and a peptide sequence (J) from beta-2-microglobulin (35-50) elicited protection from intraperitoneal viral challenge and promoted DTH responses. The H1 peptide and other H1 containing heteroconjugates did not elicit protection or DTH responses. Antibody to the H1 peptide could not be detected by ELISA following vaccination with peptide, heteroconjugate or natural infection. The LEAPS heteroconjugate appears to prime a Thl-like response which is subsequently boosted by infection. These studies show that attachment of the J peptide can make a CTL epitope into a vaccine which is immunogenic and promotes a protective Th1 type of response. 相似文献