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181.
Bogdan I. Tamba Maria‐Magdalena Leon Tudor Petreus 《Journal of neuroscience research》2013,91(4):554-561
Trace elements represent a group of essential metals or metaloids necessary for life, present in minute amounts. Analgesic adjuvants can enhance the effect of other pain drugs or be used for pain control themselves. Previous studies on the effects of trace elements on nociception and their potential use as analgesic adjuvants have yielded conflicting results. In this study, we tested the hypothesis that three vital trace elements (Zn2+, Mg2+, Cu2+) have direct antinociceptive effects. Groups of eight Swiss mice were intraperitoneally (i.p) injected with incremental concentrations of Zn2+ sulfate (0.5, 2.0 mg/kg), Zn2+ citrate (0.125, 0.5 mg/kg), Mg2+ chloride (37.5, 75, 150 mg/kg), Cu2+ chloride (0.5, 1.0, 2.0 mg/kg), and Cu2+ sulfate (0.5, 1.0 mg/kg) or saline (control). Evaluations were made by hot plate (HP) and tail flick (TF) tests for central antinociceptive effect, writhing test (WT) for visceral antinociceptive effect, and activity cage (AC) test for spontaneous behavior. Zn2+ induced pain inhibition in HP/TF tests (up to 17%) and WT (up to 25%), with no significant differences among the salts used. Mg2+ salts induced pain inhibition for all performed tests (up to 85% in WT). Cu2+ salts showed antinociceptive effects for HP/TF (up to 28.6%) and WT (57.28%). Only Mg2+ and Cu2+ salts have displayed significant effects in AC (Mg2+ anxiolytic/depressant effect; Cu2+ anxiolytic effect). We interpret these data to mean that all tested trace elements induced antinociceptive effects in central and visceral pain tests. Our data indicate the potential use of these cheap adjuvants in pain therapy. © 2013 Wiley Periodicals, Inc. 相似文献
182.
Nathan A. DeCarolis Maxwell Mechanic David Petrik Adam Carlton Jessica L. Ables Shveta Malhotra Robert Bachoo Magdalena Götz Diane C. Lagace Amelia J. Eisch 《Hippocampus》2013,23(8):708-719
Radial glia‐like cells (RGCs) are the hypothesized source of adult hippocampal neurogenesis. However, the current model of hippocampal neurogenesis does not fully incorporate the in vivo heterogeneity of RGCs. In order to better understand the contribution of different RGC subtypes to adult hippocampal neurogenesis, we employed widely used transgenic lines (Nestin‐CreERT2 and GLAST::CreERT2 mice) to explore how RGCs contribute to neurogenesis under basal conditions and after stimulation and depletion of neural progenitor cells. We first used these inducible fate‐tracking transgenic lines to define the similarities and differences in the contribution of nestin‐ and GLAST‐lineage cells to basal long‐term hippocampal neurogenesis. We then explored the ability of nestin‐ and GLAST‐lineage RGCs to contribute to neurogenesis after experimental manipulations that either ablate neurogenesis (i.c.v. application of the anti‐mitotic AraC, cytosine‐β‐D‐arabinofuranoside) or stimulate neurogenesis (wheel running). Interestingly, in both ablation and stimulation experiments, labeled RGCs in GLAST::CreERT2 mice appear to contribute to neurogenesis, whereas RGCs in Nestin‐CreERT2 mice do not. Finally, using NestinGFP reporter mice, we expanded on previous research by showing that not all RGCs in the adult dentate gyrus subgranular zone express nestin, and therefore RGCs are antigenically heterogeneous. These findings are important for the field, as they allow appropriately conservative interpretation of existing and future data that emerge from these inducible transgenic lines. These findings also raise important questions about the differences between transgenic driver lines, the heterogeneity of RGCs, and the potential differences in progenitor cell behavior between transgenic lines. As these findings highlight the possible differences in the contribution of cells to long‐term neurogenesis in vivo, they indicate that the current models of hippocampal neurogenesis should be modified to include RGC lineage heterogeneity. © 2013 Wiley Periodicals, Inc. 相似文献
183.
Lim Tammy S. H. Tan Mae Yue Aishworiya Ramkumar Kang Ying Qi Koh Magdalena Yvonne Shen Liang Chong Shang Chee 《Journal of autism and developmental disorders》2022,52(7):3026-3026
Journal of Autism and Developmental Disorders - 相似文献
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Wiener Medizinische Wochenschrift - Im vorliegenden Fallbericht wird die Situation einer 67-jährigen chronischen Schmerzpatientin geschildert, die aufgrund eines Zufallsbefundes mit der... 相似文献
186.
Badria Al-Ghaithi Rahul Chanchlani Magdalena Riedl Paul Thorner Christoph Licht 《Pediatric nephrology (Berlin, Germany)》2016,31(11):2079-2086
Background
Post-infectious glomerulonephritis (PIGN) usually follows a benign course, but few children have an atypical, severe presentation, and these exceptional cases have been linked to the dysregulation of the complement alternative pathway (CAP). There is a considerable overlap in the histopathological features of PIGN and C3 glomerulopathy (C3G), which is also associated with CAP dysregulation but has a poorer outcome. We hypothesized that PIGN and C3G define a disease spectrum, and that in the past there may be some children with C3G who were misclassified with PIGN before C3G was described as a separate disease entity.Methods
Children with PIGN (n?=?33) diagnosed between 1985 and 2010 who underwent a renal biopsy due to their unusual course were reviewed and of them, 8 were reclassified into C3G based on the current classification criteria. Outcome was based on the degree of proteinuria, C3 level, and renal function at follow-up.Results
Sixteen (72.7%) children with typical PIGN recovered completely as compared to only 2 (25%) with C3G. Of note, children with “typical” PIGN had a more severe disease course at onset; however, the outcome at last follow up was favorable.Conclusions
Our results support the hypothesis that PIGN and C3G form a disease spectrum and have different long-term clinical implications and management strategies.187.
Chantal Loirat Fadi Fakhouri Gema Ariceta Nesrin Besbas Martin Bitzan Anna Bjerre Rosanna Coppo Francesco Emma Sally Johnson Diana Karpman Daniel Landau Craig B Langman Anne-Laure Lapeyraque Christoph Licht Carla Nester Carmine Pecoraro Magdalena Riedl Nicole C. A. J. van de Kar Johan Van de Walle Marina Vivarelli Véronique Frémeaux-Bacchi for HUS International 《Pediatric nephrology (Berlin, Germany)》2016,31(1):15-39
188.
NF‐κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance
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