儿童肥胖与高血压关系的研究

目的了解儿童肥胖与高血压的关系.方法运用病例对照研究的方法,在包头市小学生中对161对单纯性肥胖儿童及其相应对照进行了研究.结果单纯性肥胖儿童的收缩压、舒张压和高血压患病率均显著高于对照组.肥胖儿童中,肥胖程度越重,高血压患病率越高.结论在儿童时期,预防、控制肥胖是降低高血压及心血管疾病发生的重要措施.     

Estrogen replacement therapy among elderly women: results from the 1995 medicare current beneficiary survey

Research Objectives: To develop population-based estimates of estrogen replacement therapy use rates in 1995 among women over age 65 living in the community; to estimate the impact of socioeconomic and health characteristics on estrogen use. Method: Estimates are based on a large, nationally representative sample of Medicare beneficiaries; detailed self-report data were merged with Medicare claims. Results: Overall, 13.1% of women reported use of estrogen replacement therapy in 1995. Estrogen users were more likely to be white, age 65–74, with private insurance, high income, history of osteoporosis and heart problems, no history of breast cancer, and a patient of gynecologists. Conclusions: Estrogen use was substantially lower among the socioeconomically disadvantaged, controlling for medical history variables, suggesting considerable inequity in access to estrogen replacement therapy treatment.     

AS_2O_3对消化道肿瘤细胞凋亡作用的研究

目的研究AS3O3对10种消化道肿瘤细胞株的致凋亡作用。方法采用形态学观察、流式细胞仪检测及DNA电泳分析。结果发现两株细胞经AS2O3作用后有明显凋亡,三株细胞无凋亡,其余有少量凋亡。结论AS2O3对不同的消化道肿瘤细胞有不同的作用,提示AS2O3对不同细胞的致凋亡作用可能存在不同的机理。     

Public involvement in health care priority setting: an economic perspective

Background  Public involvement in health care decision making and priority setting in the UK is being promoted by recent policy initiatives. In 1993, the British Medical Association called for public consultation where rationing of services was to be undertaken. The approach to priority setting advocated by many health economists is the maximization of quality adjusted life years (QALYs). Typically, for a particular health care programme, the QALY calculation takes account of four features: (1) the number of patients receiving the programme, (2) the survival gain, (3) the gain in quality of life and, (4) the probability of treatment success. Only one feature, that relating to quality of life, is based upon public preferences. If the QALY is to be used as a tool for health care resource allocation at a societal level then it should incorporate broader societal preferences.
Methods  This study used an interview-based survey of 91 members of the general public to explore whether the traditional QALY maximization model is a good predictor of public responses to health care priority setting choices.
Results and conclusions  Many respondents did not choose consistently in line with a QALY maximization objective and were most influenced by quality of life concerns. There was little support for health care programmes that provided a prognostic improvement but left patients in relatively poor states of health. The level of respondent engagement in the survey exercise was not sensitive to the provision of supporting clinical information.     

视细胞移植术后视网膜色素上皮的结构变化

获得纯化的由大肠杆菌表达的小鼠 Ｆａｓ配体（Ｆａｓ ｌｉｇａｎｄ,ＦａｓＬ）。方法：以质粒 ｐＥＴ－１５ｂ为载体,在大肠杆菌ＢＬ２１（ＤＥ３）中表达小鼠的ＦａｓＬ,用金属螫合亲和层析法纯化。结果：转化菌中,重组质粒是稳定的,异丙基－β－Ｄ硫代半乳糖苷可诱导小鼠ＦａｓＬ的表达 ,金属螫合亲和层析法可以初步纯化此蛋白。结论：在大肠杆菌中表达出小鼠的ＦａｓＬ,并得到初步纯化。     

增免灵对活动性肺结核患者的疗效及外周血T淋巴细胞亚群的影响

目的　比较常规疗法伍用增免灵与单用常规疗法对活动性肺结核的疗效及外周血Ｔ 淋巴细胞亚群的影响。方法　抽取常规化疗组（６１ 例）、常规化疗加增免灵组（７２ 例） 及健康对照组（３５ 例） 患者外周血,用ＡＰＡＡＰ法测定外周血淋巴细胞亚群。结果　活动性肺结核患者外周血ＣＤ＋３ 及ＣＤ＋４ 百分率及ＣＤ＋４ ／ＣＤ＋８ 比值显著低于健康对照组（ Ｐ＜ ０．０５） ,ＣＤ＋８ 高于健康对照组。结论　短程化疗伍用增免灵可显著改善活动性肺结核的疗效及细胞免疫状况。     

RT-PCR检测慢性粒细胞白血病患者骨髓细胞集落bcr/abl mRNA的表达

采用ＲＴＰＣＲ 技术对ＣＭＬ 患者骨髓细胞１４ ｄ 的细胞集落群和部分１４ ｄ 或２８ ｄ 的单个细胞集落ｂｃｒ／ａｂｌ ｍ ＲＮＡ 表达进行分析。结果显示：所检测的骨髓细胞集落ｂｃｒ／ａｂｌ 基因的表达均呈阳性,即为ＣＭＬ 集落,与细胞遗传学分析结果一致。该方法为研究ＣＭＬ 造血前体细胞基因表达及其诊断、治疗监测提供了灵敏、有效的分析手段;并可作为研究ＣＭＬ 发病、治疗及筛选抗ＣＭＬ 药物较为理想的方法。     

尾部悬吊及恢复过程中大鼠动脉血管收缩反应的变化

目的 探讨模拟失重下动脉收缩反应变化的时程特征及其可逆性。方法 采用尾部悬吊大鼠模型模拟失重,利用离休动脉环测定血管收缩反应的变化。结果 尾部悬吊２ｗｋ后,大鼠的腹主动脉、肠系膜动脉和股动脉收缩反应明显降低,而颈总动脉无明显改变;悬吊４ｗｋ后,肠系膜动脉和股动脉的收缩反应与悬吊２ｗｋ相比有进一步的降低;悬吊８ｗｋ大鼠的动脉血管收缩反应性与悬吊４ｗｋ相比无明显差异;４ｗｋ尾部悬吊大鼠解除悬吊后５ｗｋ     

模拟失重大鼠比目鱼肌小动脉风各级血管内径的变化

目的 探讨模拟失重是否可引起后肢肌肉小动脉网各级血管内径发生改变及其可逆性。方法 采用墨汁灌注法观察尾部悬吊４ｗｋ（ＳＵＳ－４）,悬吊４ｗｋ后恢复１ｗｋ（ＲＥＣ－１）、恢复５ｗｋ（ＲＥＣ－５）,以及对照（ＣＯＮ）大鼠比目鱼肌小动脉网各组血管内径的变化。结果 在ＳＵＳ－４组,比目鱼肌的营养动脉、弓状小动脉及Ｖ、Ⅱ级模行小动脉的内径,较ＣＯＮ组分别减小了３１％、２９％、２８％及４１％（均为Ｐ〈０．０１