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971.
乙型肝炎患者血清丁型肝炎病毒标志的研究 总被引:2,自引:0,他引:2
目的 研究HDV重叠HBV感染对乙型肝炎患者病情和血清学指标的影响。方法 采用ELISA法检测HDV血清标志HDAg、抗HD、抗HDIgM和HBV血清标志HBsAg、抗HBs、HBeAg、抗HBc、抗HBclgM,PCR法检测HBVDNA。结果 316例乙型病毒性肝炎中60例重叠HDV感染,重叠感染率为18.98%;CH和FH组HDV感染率显著高于AH,FH组HDV复制指标阳性率显著高于CH及AH 相似文献
972.
76例老年人蛛网膜下腔出血的临床特点 总被引:1,自引:0,他引:1
目的 探讨老年人蛛网膜下腔出血的特点。方法 回顾分析1989年1月-1998年8月收治60岁以上原发性蛛网膜下腔出血76例的临床资料。结果 本组老年蛛网膜下腔出血的临床特点为:(1)头痛发生率低且程度较轻,脑膜刺激征不明显;(2)意识障碍,精神症状明显;(3)消化道出血,ECG明显异常及血糖明显升高等并发症多见。结论 如老年人突然出现眩晕、精神异常或突发颈、臂、腰背疼痛等脊神经刺激征状时,应考虑到 相似文献
973.
974.
葛根素治疗52例冠心病心绞痛疗效观察 总被引:5,自引:0,他引:5
目的:探讨冠心病心绞痛药物治疗的效果。方法:将104例冠心病心绞痛患者随机分成两组:A组选用葛根素注射液500mg加入5%葡萄糖500ml静脉滴注治疗,B组采用镁-极化液500ml静脉滴注,1次/d,14d为1个观察疗程。结果:缓解心绞痛症状,A组总有效率达84.6%,与B组总有效率42.3%相比较有非常显著差异(P〈0.01)心肌缺血改善后心电图评定,A组总有效率69.23%,与B组总有效率34 相似文献
975.
976.
Xueping Yu Yijuan Zheng Dawu Zeng Yongjun Zhou Jian Sun Milong Su Huatang Zhang Minhui Zheng Zhipeng Huang Wenwu Lin Richeng Mao Jiming Zhang Chunfu Zheng Zhijun Su 《Journal of medical virology》2023,95(1):e28129
CD7 and CD57 are related to the differentiation and functional stages of CD8+ T cells. However, the role of their combined presence in CD8+ T cells in patients with chronic hepatitis B virus (HBV) infection, especially those with end-stage liver disease, remains unclear. Blood samples from healthy volunteers and patients with chronic hepatitis B were analyzed via Luminex assay and ELISA to measure plasma cytokine levels. Further, recombinant IL-22 was used to stimulate peripheral blood mononuclear cells from healthy volunteers, and the frequency of CD3+CD4−CD7+CD57− T cells and apoptosis rates were investigated via flow cytometry. Patients with end-stage liver disease, particularly those with acute to chronic liver failure, showed decreased CD3+CD4−CD7+CD57− T cell frequency. Furthermore, the prevalence of CD3+CD4−CD7+CD57− T cells was negatively correlated with disease severity, prognosis, and complications (ascites). We also observed that IL-22 promoted apoptosis and brought about a decrease in the number of CD3+CD4−CD7+CD57− T cells in a dose-dependent manner. CD3+CD4−CD7+CD57− T cells displayed a B and T lymphocyte attenuator (BTLA)highCD25highCD127high immunosuppressive phenotype and showed low interferon-γ, tumor necrosis factor-α, granzyme A, and perforin expression levels. The present findings will elucidate the pathogenesis of HBV-related end-stage liver disease and aid the identification of novel drug targets. 相似文献
977.
Yi-Fei Zhang Jing-Jing Guo Fan Yang Hang-Yu Zhou Na-Na Zhang Xiao-Chuan Xiong Yue Feng Yong-Qiang Deng Cheng-Feng Qin 《Journal of medical virology》2023,95(1):e28290
The geographic range of Zika virus (ZIKV) has expanded from Asia to the Americas, leading to the 2015–2016 pandemic with enhanced neurovirulence. At present, ZIKV is continuously circulating in many Southeast Asian countries. Unfortunately, the persistent evolution of ZIKV in Southeast Asia and its influence on the biological characteristics of the virus remain incompletely understood. In this study, the in vitro and in vivo properties of a new ZIKV isolate obtained from Cambodia in 2019 (CAM/2019) were characterized and compared with those of the Cambodian strain (CAM/2010). Compared with CAM/2010, the CAM/2019 virus showed similar plaque morphology and growth curves in cell cultures and induced comparable viremia and organ viral loads profiles in both BALB/c and A129 (IFNAR1−/−) mice upon intraperitoneal (i.p.) inoculation. Remarkably, the CAM/2019 virus exhibited enhanced neurovirulence in neonatal mice compared with CAM/2010, with a 74-fold reduction in the 50% lethal dose (LD50). Consistently, CAM/2019 produced higher viral loads in the brains of BALB/c neonatal mice than CAM/2010 did. Sequence alignment showed that the CAM/2019 virus has acquired 12 amino acid substitutions, several of which were found to be associated with neurovirulence. In particular, the CAM/2019 virus shared an A1204T substitution in NS2A with the Thai isolate SI-BKK02 that was isolated from a microcephaly case. Taken together, our results indicate that a ZIKV strain isolated with specific mutations has emerged in Cambodia, highlighting the need for extensive molecular and disease surveillance in Cambodia and other Asian countries. 相似文献
978.
五灵胶囊治疗慢性肝炎的临床随访观察 总被引:13,自引:3,他引:10
0 引言 五灵丸治疗慢性病毒性肝炎取得了较好的疗效 [1 ] ,但五灵丸为大蜜丸 ,不易被患者所接受 ,且其消化道副作用较明显 .为此 ,我们改进剂型 ,研制成五灵胶囊 ,为明确其能否保持远期疗效 ,我们对用该药治疗的患者进行随访观察 ,同时与五灵丸的疗效进行比较 .1 对象和方法1.1 病例选择 按慢性肝炎的诊断标准选择住院患者 10 0例 ,随机分为两组 .治疗组为五灵胶囊组 ,对照组为五灵丸组 .每组各 5 0例 .治疗组轻度 19例 ,中度 2 0例 ,重度 11例 .对照组轻度 2 0例 ,中度 18例 ,重度 12例 .两组均选择 18~5 8岁 ,病程 1~ 2 0 a.平均 4… 相似文献
979.
980.