全文获取类型
收费全文 | 1462篇 |
免费 | 98篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 16篇 |
妇产科学 | 117篇 |
基础医学 | 158篇 |
口腔科学 | 5篇 |
临床医学 | 138篇 |
内科学 | 203篇 |
皮肤病学 | 33篇 |
神经病学 | 78篇 |
特种医学 | 46篇 |
外科学 | 190篇 |
综合类 | 152篇 |
预防医学 | 100篇 |
眼科学 | 29篇 |
药学 | 135篇 |
2篇 | |
中国医学 | 92篇 |
肿瘤学 | 108篇 |
出版年
2024年 | 5篇 |
2023年 | 10篇 |
2022年 | 40篇 |
2021年 | 44篇 |
2020年 | 35篇 |
2019年 | 29篇 |
2018年 | 38篇 |
2017年 | 45篇 |
2016年 | 37篇 |
2015年 | 58篇 |
2014年 | 70篇 |
2013年 | 74篇 |
2012年 | 75篇 |
2011年 | 89篇 |
2010年 | 54篇 |
2009年 | 49篇 |
2008年 | 89篇 |
2007年 | 82篇 |
2006年 | 53篇 |
2005年 | 76篇 |
2004年 | 61篇 |
2003年 | 57篇 |
2002年 | 53篇 |
2001年 | 46篇 |
2000年 | 45篇 |
1999年 | 57篇 |
1998年 | 21篇 |
1997年 | 15篇 |
1996年 | 22篇 |
1995年 | 11篇 |
1994年 | 9篇 |
1993年 | 15篇 |
1992年 | 7篇 |
1991年 | 14篇 |
1990年 | 19篇 |
1989年 | 17篇 |
1988年 | 22篇 |
1987年 | 20篇 |
1986年 | 3篇 |
1985年 | 13篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1972年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有1616条查询结果,搜索用时 15 毫秒
31.
32.
James B. Chen Abraham D. Kim Lao Allan-Blitz Arya Nick Shamie 《European spine journal》2016,25(10):3082-3087
Purpose
To investigate the prevalence of thoracic scoliosis and determine the effect of both age and gender on coronal curve magnitude among asymptomatic adults aged 25–64 years old, using standing posterior-anterior chest radiographs.Methods
This was a retrospective, cross-sectional study evaluating 500 randomly selected digital posterior-anterior chest radiographs taken at a single institution on an outpatient basis between January 2010 and December 2011. Males (n = 184) and females (n = 316) ranged in age from 25 to 64 years. Patients with symptoms of back pain; including a history of back pain, spinal instrumentation, or known pre-existing spinal disease were excluded. Radiographs were evaluated using Centricity PACS Web Diagnostic 2.1 system (General Electric Co. Fairfield, CT). Coronal Cobb angle measurements of the thoracic spine were quantified by the authors, with scoliosis defined as coronal curves greater than 10°. Curvatures were subdivided into groups: a control group with coronal curves less than 10°, curves measuring 10° to 19°, 20° to 29°, and greater than 30°. The effect of age and gender on curve magnitude was examined using Pearson correlation analysis and linear regression analysis.Results
There was a 13.4 % (67 patients) prevalence of thoracic scoliosis. The prevalence among asymptomatic males was 10.9 %, while the prevalence among asymptomatic females was 14.9 %. 11.6 % demonstrated a coronal curvature between 10° and 19° (58 patients), 1.6 % between 20° and 29° (8 patients), and 0.2 % greater than 30° (1 patient). Age and gender were not found to be significant independent predictors of curve severity.Conclusions
We found a 13.4 % prevalence of thoracic scoliosis among asymptomatic adults aged 25–64 years on routine outpatient chest radiographs. 11.6 % of patients demonstrated a coronal curvature between 10° and 19°. Unlike prior studies evaluating asymptomatic thoracic curves in elderly patients, age and gender did not significantly affect curve magnitude in our younger cohort. These data may provide a reference point to help clinicians counsel asymptomatic patients diagnosed with thoracic scoliosis on routine chest radiographs.33.
34.
35.
Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies 总被引:12,自引:0,他引:12
Liu SJ Cai ZW Liu YJ Dong MY Sun LQ Hu GF Wei YY Lao WD 《World journal of gastroenterology : WJG》2004,10(9):1246-1249
AIM: To examine the role of nucleostemin in the growth regulation of gastric cancer, liver cancer and other cancers. METHODS: RT-PCR was used to clone the fragment of nucleostemin cDNA from HEK 293 cells. Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization. RESULTS: We successfully cloned a 570 bp fragment of nucleostemin-cDNA from HEK-293 cells. All detected malignant tumor tissues, benign tumor tissues, and benign hyperplastic tissues had high levels of nucleostemin expression. Nucleostemin was also expressed in human placenta tissue at a high level. In terminally differentiated normal human adult kidney and mammary gland tissues, no nucleostemin expression could be detected. CONCLUSION: Nucleostemin can help regulate the proliferation of both cancer cells and stem cells. It might play an important role in the growth regulation of gastric cancer, liver cancer and other cancers. 相似文献
36.
Bo Xiang Zhenxing Yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu 《神经科学通报》2014,30(1):33-42
Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. 相似文献
37.
38.
39.
40.
Anatomy of cutaneous perforators of the posterior tibial artery were studied in 20 limbs of 10 cadavers. The majority of the perforators (n = 74, 61%) were located in the middle two quarters of the leg, at an average of 18.6 cm (s.d. 4.5 cm; range 10.5–26 cm) from the medial malleolus, or around 54% (s.d 16%) of the length of the leg. There were usually 3 or 4 perforators in this region, with an average caliber of 1.5 mm (s.d. 0.2 mm; range 1–2 m.m.) and an average length from the posterior tibial artery to the skin of 4.0 cm (s.d. 1.3 cm; range 2.5–6 c.m.). A free fasciocutaneous skin flap based on one of these perforators (the posterior tibial perforator flap, PTP flap) was successfully transplanted in 6 cases. This modified technique of the posterior tibial flap enables the surgeon to retain the posterior tibial artery when the skin of the medial aspect of the leg is chosen to be used as skin flap donor © 1997 Wiley-Liss, Inc MICROSURGERY 17:503–511 1996 相似文献