不同类型儿童弱视的视觉眼电图研究

目的：探讨不同类型弱视在视网膜水平的改变。方法：对４种类型的弱视儿童８６例分别进行ＶＥＯＧ测试,并与正常对照组进行比较分析。结果：形觉剥夺性弱视组的光峰电位、电势差值和Ａｒｄｅｎ比明显偏高;屈光参差性弱视组光峰电位偏低,光峰时间延长;屈光不正性弱视组中,近视屈光状态者暗谷电位增大,Ａｒｄｅｎ比与Ｇｌｉｅｍ比偏低,远视屈光状态者则无明显变化;斜视性弱视组各参数未见明显差异。结论：提示在视网膜水平不同     

门诊式森田疗法治疗44例社交恐怖症

目的 :探讨门诊式森田疗法对社交恐怖症的治疗效果 ,为治疗社交恐怖症开辟新途径。方法 :采用门诊式森田疗法治疗社交恐怖症 44例。治疗前后分别用焦虑自评量表(SAS)、抑郁自评量表 (SDS)测量 ,并进行比较。按照《森田心理疗法实践》中提出的评定方法进行疗效评定。结果 :经过 3次～ 1 4次 ( 2 1d～ 1 50d)的治疗 ,44例患者治愈 2 6例( 59 1 % ) ,好转 1 5例 ( 34 1 % ) ,总有效率为 93 2 %。治疗后SAS、SDS得分显著降低 (P<0 0 1 )。结论 :门诊式森田疗法治疗社交恐怖症有效。与住院式森田疗法相比更经济、更灵活 ,适用于症状较轻、领悟力、忍耐力较强的患者。     

雌激素对氧化型低密度脂蛋白诱导的血管内皮细胞凋亡的影响

目的：观察雌激素（１７β－雌二醇）对氧化型低密度脂蛋白（ｏｘＬＤＬ）诱导人脐静脉内皮细胞（ＨＵＶＥＣ）凋亡的影响。方法 以ＨＵＶＥＣ为对象,观察不同浓度的１７β－雌二醇（１,１０和１００μｍｏｌ／Ｌ）对ｏｘＬＤＬ（４μｇ／Ｌ）诱导的凋亡的影响。结果 不同剂量的１７β－雌二醇对使用ｏｘＬＤＬ诱导的ＨＵＶＥＣ凋亡减少７０％￣９３％,其抑制呈明显的正向量效应关系,１７β－雌二醇１μｍｏｌ／Ｌ组细胞凋亡占     

人体牙齿颜色测量系统口内活体牙测量重复性的研究

对人体牙齿颜色测量系统的重复性进行研究。方法：采用ＣＩＥ１９７６Ｌ＾＊ａ＾＊ｂ＾＊色度参数对７名自愿者上中切牙进行测量,通过比较不同时间、不同损伤者测量结果差异,计算、比较不同时间测量色差偏差的大小,研究人体牙齿颜色测量系统的重复性。结果：本实验所测人体牙齿颜色系统在不同时间测量结果的色差偏差为１．０２６个单位,且不同时间比较该色差值无显著性差异;不同时间内测量指标比较除ａ＾＊以外,Ｌ＾＊,ｂ＾＊     

人性的复苏——解析霍桑《红字》的人物

《红字》表达的深刻含义一直以来都是评论家们争论的焦点。文中从人性这个角度来诠释《红字》中3个主要的人物,探讨在清教的专制统治下,个人在自由与权威中的挣扎以及主人公在此压制下人性的发展,以此揭示作者霍桑本人的内心世界,即内心对爱的欲求以及呼吁人以极大的勇气抛弃虚伪、回归真实的人性。     

Characterization of lipopeptide produced by Bacillus altitudinis Q7 and inhibitory effect on Alternaria alternata

This study identified the antifungal metabolites produced by Bacillus altitudinis Q7 against Alternaria alternata and investigated the antifungal activity and antifungal action. Lipopeptide, the important secondary metabolites were identified by Fourier transform infrared (FTIR) and liquid chromatography-mass spectrometry as lichenysin. The antifungal activity of lipopeptide on A. alternata was determined by microdilution technique, and its minimum inhibitory concentration was 1.2 mg/ml. Stability test showed that lipopeptide had excellent temperature and pH resistance. To investigate whether lichenysin acted on the cell membrane and changed its permeability, the ultra-violet absorption of protein and nucleic acid were measured using a colorimetric method. The antifungal metabolites produced by B. altitudinis Q7 was lichenysin, which showed stable antifungal activity in the extreme environments. Lichenysin could inhibit A. alternata by altering the permeability of cell membrane, leading to the outflow of proteins and nucleic acids from the cytoplasm. This research suggests the lipopeptide from B. altitudinis Q7 is a potential biological control agent against A. alternata.     

基于多尺度特征融合与反向注意力的COVID-19病灶分割

针对新型冠状病毒肺炎（COVID-19）分割问题中感染区域具有高变异性以及病灶与背景对比度低等问题,提出一种基于多尺度特征融合与反向注意力的COVID-19感染分割网络。首先,利用残差网络作为主干网络进行特征提取,并使用全局上下文聚合策略对不同层次特征进行融合得到粗略的分割结果;其次,在网络瓶颈处添加多尺度特征融合模块,利用空洞卷积与多核池化增强网络分割不同尺度病变的能力;最后,设计一种级联结构的反向注意力模块,利用互补区域的细节特征增强背景与目标的对比度。本文方法在COVID-19 CT分割测试集上的准确率、特异性、灵敏度分别达到0.714、0.700和0.958,误检和漏检区域明显减少,细小病灶的分割能力显著提升。     

IDO1 高表达与肺鳞癌临床分期及不良预后相关

目的 探讨不同分期肺鳞癌组织中 IDO1 的表达情况及与预后的关系。 方法 纳入河北医科大学 附属医院邢台市人民医院胸外科自 2017 年 1 月至 2019 年 1 月开展手术根治的肺鳞癌患者, 留取患者术中 癌组织标本, 用免疫组织化学染色法检测 IDO1 的表达情况, 并对患者进行术后随访。 结果 肺鳞癌组织 中有 IDO1 蛋白表达, 且临床Ⅱ ~ Ⅲ期阳性细胞数显著高于Ⅰ期。 截止随访结束时, 30 例患者中 28 例存 活, 2 例死亡, 疾病稳定 22 例 (73. 3 % ), 疾病进展 8 例 (26. 7 % )。 IDO1 高表达组和低表达组的无进展 生存期 (PFS) 分别为 26 个月和 40 个月, 差异具有统计学意义 (P< 0. 05); 高临床分期和低临床分期 PFS 分别为 33 个月和 40 个月, 差异具有统计学意义 (P< 0. 05)。 结论 IDO1 在肺鳞癌中表达量与临床分期有 关, 临床分期越高表达量越高, 患者预后也越差; IDO1 能指导临床分期和预后。     

FUNCTIONAL MAPPING OF THE HUMAN BRAIN DURING ACUPUNCTURE WITH MAGNETIC RESONANCE IMAGING SOMATOSENSORY CORTEX ACTIVATION

1NTRODUCTIONHegu(Ll4)isoneofthemosteffectiveandmostfrequentlyusedacupointsintraditionalChineseacupuncture.ItisindicatedfOrpaininmanypartsofthebody,butisparticularlyeffec-tiveforheadache,migraine,toothache,sorethroatandotherd1sordersoftheheadandface.Manyanimalexperimentsindicatethathighercentersinthenervoussystemareinvolvedinacupunctureanalgesia["2]butdirectevidenceforhumansubjectsisdifficulttoobtainuntilthere-centadventofpowerfu1andn0n-invasivemeth-odsforneuroimaginginthe9O's.Werecentlya…     

Presynaptic inhibition of synaptic transmission in the rat hippocampus by activation of muscarinic receptors: involvement of presynaptic calcium influx

1. Modulation of presynaptic voltage-dependent calcium channels (VDCCs) by muscarinic receptors at the CA3–CA1 synapse of rat hippocampal slices was investigated by using the calcium indicator fura-2. Stimulation-evoked presynaptic calcium transients ([Ca_pre]_t) and field excitatory postsynaptic potentials (fe.p.s.ps) were simultaneously recorded. The relationship between presynaptic calcium influx and synaptic transmission was studied.
2. Activation of muscarinic receptors inhibited [Ca_pre]_t, thereby reducing synaptic transmission. Carbachol (CCh, 10 μM) inhibited [Ca_pre]_t by 35% and reduced fe.p.s.p. by 85%. The inhibition was completely antagonized by 1 μM atropine. An approximate 4^th power relationship was found between presynaptic calcium influx and postsynaptic responses.
3. Application of the N-type VDCC-blocking peptide toxin ω-conotoxin GVIA (ω-CTx GVIA, 1 μM) inhibited [Ca_pre]_t and fe.p.s.ps by 21% and 49%, respectively, while the P/Q-type VDCC blocker ω-agatoxin IVA (ω-Aga IVA, 1 μM) reduced [Ca_pre]_t and fe.p.s.ps by 35% and 85%, respectively.
4. Muscarinic receptor activation differentially inhibited distinct presynaptic VDCCs. ω-CTx GVIA-sensitive calcium channels were inhibited by muscarinic receptors, while ω-Aga IVA-sensitive channels were not. The percentage inhibition of ω-CTx GVIA-sensitive [Ca_pre]_t was about 63%.
5. Muscarinic receptors inhibited presynaptic VDCCs in a way similar to adenosine (Ad) receptors. The percentage inhibition of ω-CTx GVIA-sensitive [Ca_pre]_t by Ad (100 μM) was about 59%. There was no significant inhibition of ω-Aga IVA-sensitive channels by Ad. The inhibitions of [Ca_pre]_t by CCh and Ad were mutually occlusive.
6. These results indicate that inhibition of synaptic transmission by muscarinic receptors is mainly the consequence of a reduction of the [Ca_pre]_t due to inhibition of presynaptic VDCCs.