机械加工业工人体力劳动强度与能量消耗调查研究

本文调查研究了机械加工业工人体力劳动强度与能量消耗。结果表明机械加工业工人８小时工作日净劳动时间为３４５分钟，在工时利用率为７１．８９％，劳动能量代谢率平均为１．８９７８千卡／米２·分，８小时工作日总能量消耗为：７９２．８千卡，远低于卫生学限度。按照国家体力劳动强度分级标准判断，Ⅰ级占６６．６７％；Ⅱ级占３０．０３％，Ⅲ级占３．０３％。提示在目前生产技术水平下，机械加工业工人体力劳动强度和能量消耗均偏低。     

运动员维生素E营养水平初探

采用荧光分光光度法对４０名北京体院竞技体校运动员和３０名普通大学生维生素Ｅ（ＶＥ）营养水平作了调查，结果表明：①运动员组与大学生组平均血清ＶＥ含量分别为１．２０±０．２８ｍｇ／ｄｌ和１．３３±０．３３ｍｇ／ｄｌ，运动员明显低于大学生组（Ｐ＜０．０５）。②竞走及中长跑组与短跑组平均血清ＶＥ含量分别为１．２４±０．２６ｍｇ／ｄｌ和１．１８±０．２９ｍｇ／ｄｌ，二者无明显差异（Ｐ＞０．０５）。而将这两组与大学生组比，则短跑组表现的差异大（Ｐ＜０．０５），竞走及中长跑组与大学生组没有显著性差异（Ｐ＞０．０５）。③从血中ＶＥ／ＴＣ（胆固醇）比值看，运动员组虽有低于大学生组的趋势，但两者无显著性差异（Ｐ＞０．０５）。运动员的ＶＥ营养状况是否存在不同于普通大学生的现象仍有待进一步的研究。     

顽固性口腔溃疡复发的危险因素分析

【摘要】 目的 回顾性分析顽固性口腔溃疡复发的相关危险因素。方法 选取 2019 年 1 月至 2020 年 10 月沈阳七三九医院收治的 125 例顽固性口腔溃疡患者作为研究对象, 收集患者年龄、性别、是否饮酒、是否吸烟?是否喝茶、饮食类型、是否使用药物牙膏、牙刷毛硬度、刷牙次数、是否熬夜失眠、疲劳状态、心理状态、是否合并消化系统疾病等资料, 根据口腔溃疡治愈后3个月是否再发口腔溃疡将患者分为复发组和未复发组,多因素Logistic 回归分析顽固性口腔溃疡复发的相关危险因素。结果 125 例顽固性口腔溃疡患者愈后 3 个月再发口腔溃疡者 32 例,设为复发组;未再发口腔溃疡者93例,设为未复发组。多因素Logistic回归分析结果显示,年龄≥60岁、吸烟、饮食偏荤、使用药物牙膏、刷牙次数≤1 次/天、熬夜失眠、疲劳、心理异常、合并消化系统疾病是顽固性口腔溃疡患者复发的独立危险因素 (95% CI为1.016 ~ 1.134、1.003 ~ 1.164、1.001 ~ 1.397、1.024 ~1.364、1.029 ~ 1.413、1.019 ~ 1.433、1.027 ~ 1.389、1.041 ~ 1.397、1.024 ~ 1.369, P = 0.011、0.046、0.048?0.022、0.021、0.030、0.021、0.013、0.022)。结论 顽固性口腔溃疡的复发与患者的年龄、生活习惯、心理状态等多种因素密切相关。     

河南“4.26”60Co源辐射事故一例受照者患非霍奇金淋巴瘤的病因探讨

关于电离辐射是否可诱发非霍奇金淋巴瘤（NHL）,目前的研究结果尚未获得一致结论。笔者报道了河南“4.26” 60Co源辐射事故中1例中度骨髓型急性放射病患者受照后第13年患NHL的病例,结合患者的受照史、病史特点、诊断及国际多项大型研究,从流行病学资料和影响因素两方面分析了患者“天”患非霍奇金淋巴瘤与电离辐射的关系,为电离辐射致NHL提供辐射流行病学依据。     

Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma

Background

Microscopic tumor involvement (R1) in different surgical resection margins after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) has been debated.

Methods

Clinico-pathological data for 258 patients who underwent PD between 2001 and 2010 were retrieved from a prospective database. The rates of R1 resection in the circumferential resection margin (pancreatic transection, medial, posterior, and anterior surfaces) and their prognostic influence on survival were assessed.

Results

For PDAC, the R1 rate was 57.1?% (48/84) for any margin, 31.0?% (26/84) for anterior surface, 42.9?% (36/84) for posterior surface, 29.8?% (25/84) for medial margin, and 7.1?% (3/84) for pancreatic transection margin. Overall and disease-free survival for R1 resections were significantly worse than those for R0 resection (17.2 vs. 28.7?months, P?=?0.007 and 12.3 vs. 21.0?months, P?=?0.019, respectively). For individual margins, only medial positivity had a significant impact on survival (13.8 vs. 28.0?months, P?<?0.001), as opposed to involvement in the anterior (19.7 vs. 23.3?months, P?=?0.187) or posterior margin (17.5 vs. 24.2?months, P?=?0.104). Multivariate analysis demonstrated R0 medial margin was an independent prognostic factor (P?=?0.002, HR?=?0.381; 95?% CI 0.207?C0.701).

Conclusion

The medial surgical resection margin is the most important after PD for PDAC, and an R1 resection here predicts poor survival.     

调节内质网应激对糖尿病小鼠肾脏SET7/9表达的影响

目的 探讨调节内质网应激对小鼠肾组织组蛋白甲基转移酶(HMT) SET7/9表达的影响及意义.方法 db/db小鼠按随机数字表法分为糖尿病肾病(DN)组和甜菜碱治疗(DN+B)组;db/m小鼠作为正常对照(NC)组,每组各18只.实验第4、8、12周末分别采用实时定量PCR和(或)Western印迹法测定小鼠肾组织SET7/9、葡萄糖调节蛋白(GRP)78、H3K4me2和单核细胞趋化蛋白1(MCP-1)表达水平;ELISA法测定24 h尿蛋白排泄率(UPER)和尿MCP-1浓度;全自动生化分析仪检测血糖(BG)、血肌酐、血尿素氮的动态改变;PAS染色观察肾脏病理改变.结果 与NC组比较,DN组BG、BUN、UPER、MCP-1均显著升高(均P＜0.05),且呈时间依赖性.DN组小鼠第4周末开始出现肾小球基底膜增厚、系膜细胞增生改变,第12周末出现明显系膜基质积聚.与NC组比较,DN组肾组织GRP78、SET7/9的mRNA和蛋白质表达水平均显著升高,H3K4me2蛋白水平也显著升高,且呈时间依赖效应.与DN组比较,甜菜碱治疗组小鼠肾小球病变明显减轻,GRP78、SET7/9的mRNA及蛋白表达水平显著降低,BG、BUN、UPER、MCP-1、H3K4me2水平显著降低(均P＜0.05).结论 内质网应激可能是介导糖尿病小鼠肾脏SET7/9表达的上游机制.     

Ti:sapphire femtosecond laser ablation of dental enamel, dentine, and cementum

This paper reports an investigation into the characteristics of femtosecond laser (800-nm central wavelength) in the ablation of human dental enamel, dentine, and cementum at various laser fluences from 0.2 to 3.68 J/cm² with single and multiple pulses. The femtosecond laser interaction with cementum is reported for the first time. Ablation thresholds were determined to be 0.58, 0.44, and 0.51 J/cm² for enamel, dentine, and cementum, respectively. Under the average laser fluences of 1.13 to 3.68 J/cm², clean ablated surfaces without debris and microcracks were obtained. Laser fluence was found to influence the ablated diameter and depth, whereas under a certain fluence, pulse number only affects the depth, without affecting the diameter. The ablation mechanism is found to be based on multi-photon absorption, not previously known for femtosecond laser ablation of dental materials. The low thermal loads of 0.708, 1.44, and 0.404 J/cm³ required for ablating enamel, dentine, and cementum, determined for the first time, are beneficial for minimizing the heat-affected zones and micro-damage. The Raman spectroscopic analysis of phosphate shows that the chemical components of the tooth remain intact before and after the fs-laser ablation. It also shows that different dental tissues respond differently to the laser irradiation.     

异体复合组织移植皮肤淋巴引流隔绝动物模型的建立

目的:通过SD大鼠下腹部游离皮瓣及皮管的移植,建立大鼠异体复合组织移植皮肤淋巴引流隔绝模型。方法:7～8周龄雄性SD大鼠切取下腹部皮瓣并游离行同种异体移植,皮肤隔离组(A组):将供体皮瓣边缘对合、缝合成管状,底边留血管蒂出口用隔离器隔离皮肤,显微外科吻合血管,皮管缝合于隔离器,隔离器固定于受体;皮肤未隔离组(B组):将供体游离皮瓣卷制成管状,显微外科吻合血管并将供受体皮肤对位缝合;空白对照组(C组):行下腹部游离皮瓣异体移植。大体观察每组皮瓣或皮管存活时间,于术后3、5、7、14、28、35d取移植物皮肤组织行HE染色,观察病理学变化。结果:A组:皮管存活时间为32(34,32)天;B组:皮管存活时间为15(16,15)天;C组:皮瓣存活时间为6(7,6)天。A组与C组、B组与C组、A组与B组存活率差异均有统计学意义(P<0.05)。结论:本实验成功建立了大鼠的异体复合组织移植淋巴引流隔绝模型,并证实了隔绝皮肤淋巴引流能有效延长移植物的存活时间。     

A novel approach to gallbladder cancer in a Jehovah’s Witness

Radiofrequency interstitial thermal ablation (RITA) provides a palliative option for patients suffering from metastatic liver disease. This procedure can be performed using a laparoscopic approach with laparoscopic ultrasound used to position the RITA probe. We describe a case of laparoscopic RITA performed for colorectal liver metastasis that was complicated by tumor lysis syndrome (TLS) following treatment. We consider RITA to be a safe procedure, as supported by the literature, but where intracorporal tumor lysis is the treatment goal we believe that the systemic release of tumor products can overwhelm the excretory capacity; therefore, TLS is an inevitable consequence in some patients.