全文获取类型
收费全文 | 2714篇 |
免费 | 156篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 56篇 |
妇产科学 | 59篇 |
基础医学 | 306篇 |
口腔科学 | 64篇 |
临床医学 | 280篇 |
内科学 | 683篇 |
皮肤病学 | 29篇 |
神经病学 | 114篇 |
特种医学 | 95篇 |
外科学 | 429篇 |
综合类 | 84篇 |
一般理论 | 1篇 |
预防医学 | 173篇 |
眼科学 | 45篇 |
药学 | 232篇 |
中国医学 | 25篇 |
肿瘤学 | 193篇 |
出版年
2023年 | 21篇 |
2022年 | 77篇 |
2021年 | 130篇 |
2020年 | 73篇 |
2019年 | 112篇 |
2018年 | 128篇 |
2017年 | 74篇 |
2016年 | 82篇 |
2015年 | 77篇 |
2014年 | 122篇 |
2013年 | 134篇 |
2012年 | 221篇 |
2011年 | 204篇 |
2010年 | 98篇 |
2009年 | 95篇 |
2008年 | 153篇 |
2007年 | 116篇 |
2006年 | 142篇 |
2005年 | 142篇 |
2004年 | 115篇 |
2003年 | 103篇 |
2002年 | 89篇 |
2001年 | 41篇 |
2000年 | 39篇 |
1999年 | 53篇 |
1998年 | 24篇 |
1997年 | 16篇 |
1996年 | 18篇 |
1995年 | 9篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 19篇 |
1991年 | 27篇 |
1990年 | 19篇 |
1989年 | 15篇 |
1988年 | 15篇 |
1987年 | 16篇 |
1986年 | 11篇 |
1985年 | 19篇 |
1984年 | 2篇 |
1983年 | 6篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 4篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有2898条查询结果,搜索用时 15 毫秒
21.
22.
23.
Behnaz Moradi Maryam Rahmani Kolsoom Kia Mohammad Ali Kazemi Ahmad-Reza Tahmasebpour 《Taiwanese journal of obstetrics & gynecology》2019,58(6):814-819
ObjectiveCavum veli interpositi (CVI) is a potential space below the splenium of corpus callosum and sometimes presents as a cyst.Materials and methodsIn this prospective cross-sectional study, 360 fetuses with normal second trimester scan and 152 s trimester fetuses with structural abnormalities were included.ResultsThe CVI cysts were more common in fetuses with brain anomaly compared to normal fetuses and fetuses with extra-central nervous system (CNS) anomalies (23% vs 18.3% and 18% respectively; p value < 0.01). The mean size of cysts in normal fetuses, fetuses with extra-CNS anomalies and fetuses with brain abnormalities was 4.6 mm, 5.8 mm and 9.2 mm respectively. There was a significant difference between cysts size in normal fetuses and fetuses with brain anomalies (p value < 0.01) and the cut-point was 7.1 mm.ConclusionThe prevalence of CVI cysts is more in fetuses with brain anomaly. Fetuses with a cyst size >7.1 mm need a more detailed brain examination. 相似文献
24.
The epidemiology of Clostridium difficile-associated diarrhea (CDAD) in an endemic setting was investigated by use of DNA typing methods to determine the strain identity of C. difficile isolates. Two predominant toxigenic clones were found in the environment and accounted for 29.8% (type 1) and 15.5% (type 2) of CDAD cases, respectively. In endemic settings, the environment and cross-transmission may play a role in acquisition of CDAD. 相似文献
25.
Abnormal postsystolic thickening in acutely ischemic myocardium during coronary angioplasty: a velocity, strain, and strain rate doppler myocardial imaging study. 总被引:10,自引:0,他引:10
F Jamal T Kukulski J D'hooge I De Scheerder G Sutherland 《Journal of the American Society of Echocardiography》1999,12(11):994-996
We report a case in which the combination of gray scale imaging of wall thickness changes allied to color DMI regional velocity, strain, and strain rate data identified the development and regression of diastolic thickening in the acute ischemic segment during a right coronary artery percutaneous transluminal coronary angioplasty (PTCA). We also discuss the possible mechanisms and potential clinical implications of this finding. 相似文献
26.
Jing Zhao Dekuang Zhao Graham M. Poage Abhijit Mazumdar Yun Zhang Jamal L. Hill Zachary C. Hartman Michelle I. Savage Gordon B. Mills Powel H. Brown 《The Journal of clinical investigation》2015,125(7):2707-2720
Estrogen receptor–negative (ER-negative) breast cancers are extremely aggressive and associated with poor prognosis. In particular, effective treatment strategies are limited for patients diagnosed with triple receptor–negative breast cancer (TNBC), which also carries the worst prognosis of all forms of breast cancer; therefore, extensive studies have focused on the identification of molecularly targeted therapies for this tumor subtype. Here, we sought to identify molecular targets that are capable of suppressing tumorigenesis in TNBCs. Specifically, we found that death-associated protein kinase 1 (DAPK1) is essential for growth of p53-mutant cancers, which account for over 80% of TNBCs. Depletion or inhibition of DAPK1 suppressed growth of p53-mutant but not p53-WT breast cancer cells. Moreover, DAPK1 inhibition limited growth of other p53-mutant cancers, including pancreatic and ovarian cancers. DAPK1 mediated the disruption of the TSC1/TSC2 complex, resulting in activation of the mTOR pathway. Our studies demonstrated that high DAPK1 expression causes increased cancer cell growth and enhanced signaling through the mTOR/S6K pathway; evaluation of multiple breast cancer patient data sets revealed that high DAPK1 expression associates with worse outcomes in individuals with p53-mutant cancers. Together, our data support targeting DAPK1 as a potential therapeutic strategy for p53-mutant cancers. 相似文献
27.
28.
Adenosine bronchial provocation with computerized wheeze detection in young infants with prolonged cough: correlation with long-term follow-up 总被引:1,自引:0,他引:1
BACKGROUND: Chronic cough in babies is often associated with bronchial hyperreactivity (BHR). The objective documentation of BHR in babies is difficult, and acoustic methods have been described (provocative concentration of a substance causing wheeze) for conducting bronchial provocation tests (BPTs). We conducted a study to evaluate automatic computerized wheeze detection (CWD) in determining BHR in young infants with prolonged cough, and its correlation with the subsequent development of wheezing. METHODS: Infants aged < 24 months with prolonged cough (ie, > 2 months) underwent acoustic BPTs with the response determined by CWD and auscultation by a physician. Telephone interviews with parents were conducted after 1 month and yearly for the next 3 years. RESULTS: A total of 28 infants who were 4 to 24 months old with prolonged cough were included in the study. Twenty of these infants (71.4%) had BHR as determined by a positive acoustic BPT result. In 11 of these 20 tests, the CWD occurred earlier, and in 9 tests it occurred at the same step as auscultation by a physician. Rhonchi or whistles often preceded wheezes. Seventeen of the 20 patients with BHR completed 3 years of follow-up. Of these, 14 had recurrent episodes of wheezing and shortness of breath, and 3 were well. Six of the eight adenosine-negative patients completed 3 years of follow-up and had no symptoms of BHR. CONCLUSIONS: Acoustic BPT is a technically feasible test for the detection of BHR in young infants. CWD provides an earlier detection of wheeze than stethoscope auscultation. In our group of infants, a positive acoustic BPT result had high correlation with symptoms compatible with BHR over the next 3 years. 相似文献
29.
30.
Karine Petitprez Jean-Marie Grzych Christine Pierrot Claude Godin André Capron Jamal Khalife 《Parasitology research》1997,84(1):38-40
Genes encoding the heavy and light chains of an anti-idiotype antibody (AB2) mimicking a protective oligosaccharide of Schistosoma mansoni were cloned and expressed as a single-chain Fv fragment. The expression in a functional state was tested using the AB1. A
specific binding between sFv and AB1 was observed. Immunization with the recombinant AB2 indicates its capacity to elicit
anti-S. mansoni antibodies.
Received: 28 April 1997 / Accepted: 24 June 1997 相似文献