全文获取类型
收费全文 | 5189篇 |
免费 | 237篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 151篇 |
妇产科学 | 40篇 |
基础医学 | 564篇 |
口腔科学 | 140篇 |
临床医学 | 360篇 |
内科学 | 1287篇 |
皮肤病学 | 34篇 |
神经病学 | 269篇 |
特种医学 | 405篇 |
外科学 | 1128篇 |
综合类 | 16篇 |
预防医学 | 160篇 |
眼科学 | 38篇 |
药学 | 310篇 |
中国医学 | 7篇 |
肿瘤学 | 541篇 |
出版年
2023年 | 37篇 |
2022年 | 77篇 |
2021年 | 125篇 |
2020年 | 72篇 |
2019年 | 90篇 |
2018年 | 124篇 |
2017年 | 82篇 |
2016年 | 110篇 |
2015年 | 102篇 |
2014年 | 138篇 |
2013年 | 175篇 |
2012年 | 261篇 |
2011年 | 289篇 |
2010年 | 199篇 |
2009年 | 170篇 |
2008年 | 261篇 |
2007年 | 313篇 |
2006年 | 311篇 |
2005年 | 266篇 |
2004年 | 303篇 |
2003年 | 283篇 |
2002年 | 287篇 |
2001年 | 114篇 |
2000年 | 104篇 |
1999年 | 100篇 |
1998年 | 72篇 |
1997年 | 61篇 |
1996年 | 50篇 |
1995年 | 43篇 |
1994年 | 49篇 |
1993年 | 34篇 |
1992年 | 67篇 |
1991年 | 67篇 |
1990年 | 60篇 |
1989年 | 63篇 |
1988年 | 56篇 |
1987年 | 56篇 |
1986年 | 54篇 |
1985年 | 45篇 |
1984年 | 42篇 |
1983年 | 21篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1979年 | 29篇 |
1978年 | 17篇 |
1977年 | 20篇 |
1974年 | 14篇 |
1972年 | 14篇 |
1968年 | 13篇 |
1966年 | 12篇 |
排序方式: 共有5471条查询结果,搜索用时 0 毫秒
51.
Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells. 总被引:5,自引:2,他引:3 下载免费PDF全文
52.
T Arimoto G Irie H Tsujii S Ito J Mizoe T Kamada M Miyamoto H Sirato 《Radiation Medicine》1984,2(3):205-209
In this paper a so-called "supralethal dose phenomenon" is reported. Two groups of patients, all of whom were carrying proved squamous cell carcinoma of the same clinical stage in their maxillary sinuses, were compared after radiotherapy in our department. The radiotherapies applied to the two groups were very similar in terms of fraction number, treatment period, dose distribution and immobilization technique, but differed in dose, i.e., 5,500 cGy for one group of 9 patients and 5,750 cGy for the other group of 20 patients. The five-year survival rates of the two groups were 8/9 and 10/20, respectively, and the difference was statistically significant (p less than 0.05). All patients were observed for at least five years. Except for tumor stage, the status of the patients in the two groups, including primary site of the tumor in the sinus, patients' age and cause of death for the failed cases, are also discussed in detail. 相似文献
53.
54.
BackgroundShoulder 36 (Sh-36) is an original quality of life measure for shoulder lesions with high reliability and validity; however, in some cases, especially in those with a Bankart lesion, we observed no improvement in Sh-36 during the postoperative follow-up. Sh-36 may be less effective for a certain shoulder lesion. This study aimed to compare the reliability, validity, and responsiveness of Sh-36 among different representative diagnoses of shoulder lesions.MethodsSh-36 and the Disability of the Arm, Shoulder and Hand (DASH) were measured in 192 patients with a Bankart lesion (Bankart group), rotator cuff tear (Cuff group), and SLAP lesion (SLAP group) who underwent arthroscopic surgery. Both measures were evaluated before surgery, and at 3, 6, 9, 12, 18, and 24 months postoperatively, and reliability, validity, and responsiveness of Sh-36 and the DASH were compared among the three groups.ResultsSignificant postoperative improvement was observed in the three groups (p < 0.0001) within 9 months. No marked improvement was observed after 9 months in the Bankart and SLAP groups due to the ceiling effect; however, most domains of Sh-36 increased continuously in the Cuff group during the whole follow-up period. Reliability and construct validity were sufficient in all the groups. The longitudinal validity was sufficient in most domains for the three groups; however, the standardized response mean in the Bankart group was lower than that in other two groups, indicating low responsiveness in this group because of the ceiling effect.ConclusionsSh-36 was a valid and reliable instrument in patients who have undergone arthroscopic shoulder surgery, especially for patient with a rotator cuff tear with high responsiveness. However, Sh-36 had lower standard response mean representing lower responsiveness in the Bankart group due to the ceiling effect and may not be ideal for longitudinal follow-up in patients with a Bankart lesion. 相似文献
55.
H Nakarai P J Chandler K Kano D L Morton R F Irie 《International archives of allergy and applied immunology》1990,91(3):323-328
Hanganutziu-Deicher (H-D) antigen is classified as a heterophile antigen and chemically defined as a glycoconjugate which contains N-glycolylneuraminic acid. H-D antigens are absent from normal human tissues, but can be expressed on a variety of human malignant cells, including melanoma. Natural anti-H-D antibodies have been detected in man with and without malignancies, but in this study when the level of antibody was compared between healthy adults and patients with melanoma, elevated anti-H-D antibody levels were found more frequently in melanoma patients for both IgM (p = 0.0001) and IgG (p = 0.0001). The present study was designed to evaluate the significance of the H-D antigen-antibody system in melanoma suppression. Sera from melanoma patients containing anti-H-D antibody reacted strongly to H-D antigen expressed on melanoma by means of flow cytometry. In a complement-dependent cytotoxicity assay this antibody killed melanoma cells in vitro. In vivo significance of the antibody was assessed by evaluating the relationship between the antibody levels and the clinical course in patients with stage II melanoma. Antibody levels were measured by enzyme-linked immunosorbent assay using a H-D glycoprotein antigen isolated from bovine erythrocytes. A significantly higher level of IgG (p = 0.0640) and IgM (p = 0.0644) anti-H-D antibody was demonstrated in those patients who were free of disease more than 5 years after surgery than in those who relapsed within 2 years. This study provides a rational basis for immunotherapy targeting H-D antigen in human melanoma. 相似文献
56.
Shigemi K Takahashi H Hashimoto S Nomi S Chihara E Kinoshita T Tanaka Y Miyazaki M 《Journal of anesthesia》1990,4(1):91-93
Finger arterial blood pressures determined by a newly developed sphygmomanometer, HEM-802F, were compared with arterial pressure obtained from direct measurement of the radial artery. An excellent correlation was found between the two methods (systolic: r = 0.93, diastolic: r = 0.91), although there was a large variability among individual subjects. The range of differences between them are from +32 to –13mmHg for systolic and +15 to –25mmHg for diastolic blood pressure measurement. HEM-802F underestimated systolic pressure (–4.0mmHg) and overestimated diastolic pressure (+6.7mmHg), compared with intra-arterial readings.The HEM-802F was useful for the non-invasive arterial pressure monitoring during general anesthesia.(Shigemi K, Takahashi H, Hashimoto S et al.: A comparative study of measurement of arterial blood pressure using HEM-802F and arterial cannulation. J Anesth 4: 91–93, 1990) 相似文献
57.
58.
Tomomi Nakagawa Kazuyoshi Shigehara Yuki Kato Shohei Kawaguchi Hiroki Nakata Taito Nakano Kouji Izumi Yoshifumi Kadono Atsushi Mizokami 《Journal of medical virology》2023,95(1):e28110
Although urine and bladder washing samples are commonly used for the cytological evaluation of the bladder mucosa, it has been unknown whether these samples are likely suitable to investigate human papillomavirus (HPV) prevalence in the urinary bladder. The present study aimed to elucidate the appropriateness of spontaneously voided urine or bladder washing in screening HPV infection in the urinary bladder. Urine and bladder washing samples were obtained from 201 patients who underwent transurethral bladder tumor resection. After extracting DNA from both samples, HPV-DNA was examined using a nested polymerase chain reaction with GP5+/6+ and MY09/11 primers. HPV genotyping was performed in the HPV-positive samples. In situ hybridization (ISH) was performed to observe the HPV-DNA localization in urothelial cells among cytological samples and paraffin-embedded tumor tissues in HPV-positive washing samples. HPV prevalence in urine and washing samples were 9.5% and 7.0%, respectively. High-risk HPV prevalence in urine and washing samples was 7.5% and 4.0%, respectively. The most common HPV type was HPV 16, followed by HPV 52 and HPV 18 in both samples. HPV type distribution in both samples was not in agreement (κ = −0.431). The ISH analysis revealed that HPV-DNA signal was observed in urothelial cells of five (55.7%) of nine detectable HPV-positive cytological samples. Six (66.7%) of nine HPV-positive cases had HPV-DNA signals in tumor tissue. The use of washing samples was likely applicable for investigating HPV prevalence in the urinary bladder. HPV-DNA detected in washing samples might be frequently derived from the urinary bladder. 相似文献
59.
Many clinical reports have described vocal cord paralysis after general anaesthesia. In most cases, paralysis was attributed
to tracheal tube insertion. In this report we describe one patient in whom gastric tube insertion was strongly suspected as
the cause of paralysis. The patient was a 47-yr-old man who underwent left hepatic lobectomy. Just after the operation he
complained of hoarseness and a diagnosis of complete right vocal cord paralysis was made, from which he recovered after eight
weeks. In this patient, insertion of the gastric tube seemed to have injured the anterior ramus of the right recurrent laryngeal
nerve directly. Although there have been several reports of vocal cord paralysis induced by gastric tubes, none has noted
such an acute onset and direct nerve injury. Therefore we would like to report this rare case and elucidate the mechanism
of vocal cord paralysis. Careful attention should be paid in inserting a gastric tube to patients under general anaesthesia
and, sometimes, the use of the soft tube may be indicated.
Plusieurs publications portent sur la paralysie des cordes vocales après une anesthésie générale. Dans la plupart des cas,
on attribue la paralysie à l’insertion du tube endotrachéal. Ce compte-rendu se rapporte à un cas où l’insertion d’une sonde
gastrique est fortement mise en cause dans l’étiologie de la paralysie. Un patient de 47 ans subit une hépatectomie. Immédiatement
après l’intervention, il se plaint de raucité de la voix et une paralysie de la corde vocale droite est diagnostiquée. La
récupération s’effectue en huit semaines. Chez ce patient, la sonde gastrique semble avoir endommagé directement le rameau
antérieur du nerf récurrent laryngé. Bien que plusieurs observations identiques de paralysie des cordes vocales provoquée
par une sonde gastrique aient été publiées, aucune ne rapporte un début aussi soudain avec lésion nerveuse directe. Nous décrivons
ici ce cas rare et tenterons d’expliquer le mécanisme de la paralyse de la corde vocale. Il faut être très prudent lorsqu’on
insère un tube gastrique sous anesthésie générale et il est parfois préférable d’utiliser un tube mou. 相似文献
60.
Pseudolesions of the liver possibly caused by focal rib compression: analysis based on hemodynamic change 总被引:2,自引:0,他引:2
Yoshimitsu K Honda H Kuroiwa T Irie H Tajima T Jimi M Masuda K 《AJR. American journal of roentgenology》1999,172(3):645-649
OBJECTIVE: The purpose of this study is to show and analyze the CT appearance of pseudolesions of the liver caused by rib compression and to discuss the possible mechanism on the basis of findings of incremental dynamic CT, CT during arterial portography, and CT hepatic arteriography. CONCLUSION: Focal compression of the liver caused by curved ribs can cause transient focal diminishment of portal venous perfusion without significantly altering hepatic arterial perfusion. Such diminishment may be observed as low-density areas on the early phase of incremental dynamic CT. 相似文献