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31.
Ying-You Lin Cheng-Hsiang Hsiao Yung-Hsiang Hsu Chin-Cheng Lee Hsiang-Jung Tsai Ming-Jeng Pan 《台湾医志》2006,105(11):911-917
BACKGROUND/PURPOSE: Bartonella henselaeis the causative agent of cat scratch disease (CSD), manifesting as fever and acute regional lymphadenopathy. Although serologic testing is the reference method for diagnosis, successful use of immunohistochemical (IHC) stain of regional lymph nodes for the diagnosis of CSD has been reported. To determine the characterization and diagnostic potential of IHC in lymphadenopathy of CSD, lymph nodes were excised from patients with suspected CSD for further evaluation. METHODS: Polyclonal antibody-based IHC studies were performed for the detection of B. henselae. Between January 2001 and December 2004, the reference laboratory of the Center for Disease Control, Taiwan, received a total of 377 sera from 352 reported suspected CSD cases. Twenty-three formalin-fixed paraffin-embedded lymph nodes from 16 patients and two skin biopsies from two patients suspected of having CSD were included in this study. Nine of them were serologically confirmed to have CSD and the others were seronegative but suspected to have CSD by the attending physicians. Seven lymph node specimens were obtained from tuberculosis patients for comparison. RESULTS: We demonstrated that the microorganisms existed in the cytoplasm of histiocytes within the granulomatous lesions in nine lymph nodes and one skin biopsy. Among the nine lymph nodes with IHC (+) stains, three were seronegative. On the other hand, three cases were IHC (+) and six cases were IHC (-) among nine seronegative patients. In addition, two seronegative patients with skin biopsy showed one IHC (+) and one IHC (-). CONCLUSION: IHC can contribute to the etiologic diagnosis of B. henselaelymphadenopathy when serology and molecular techniques are not available. 相似文献
32.
Chih-Hsien Chang Kuo-Hsien Fan Te-Jung Chen Wei-Chun Hsu Mei-Ling Jan Tung-Hu Tsai Pan-Fu Kao Chieh-Fu Chen Ying-Kai Fu Te-Wei Lee 《台湾医志》2004,103(11):876-881
BACKGROUND AND PURPOSE: Fluorine-18-2-deoxy-D-glucose (18F-FDG) has been used in the clinic as a diagnostic radiotracer for monitoring many kinds of tumors, but its value for monitoring fibrosarcoma is not well established. METHODS: In this study, the uptake of 18F-FDG in a fibrosarcoma-bearing mouse model was evaluated using the high resolution positron emission tomography (PET) system microPET. Tumor cells were implanted in 3 FVB/N mice, and static microPET scanning was performed on day 1, 7, 12 and 15 after implantation. A dynamic microPET image was scanned on day 12 to determine the 18F-FDG uptake in 3 other tumor-bearing mice. Time-activity curves were plotted by drawing regions of interest in the tumor, liver, kidneys and muscles. The mice were sacrificed after dynamic microPET imaging and whole-body autoradiography (WBAR) was performed. For biodistribution study, 9 tumor-bearing mice, 3 per experimental group, were studied at 3 time points and the results were compared with the static microPET images. RESULTS: MicroPET images suggested that 18F-FDG could be used to monitor the growth of tumors 7 days after implantation. Dynamic scans of 18F-FDG uptake reached a plateau in the tumor after 20 minutes on day 12 after implantation. Both microPET and WBAR revealed evidence of tumor necrosis. The results of biodistribution and WBAR agreed with those from microPET images. CONCLUSION: MicroPET was useful for monitoring the growth of fibrosarcoma and determination of the maximal uptake time point of 18F-FDG in tumors in this tumor-bearing mouse model. 相似文献
33.
Jen Te Hsu Chi Ming Chu Shih Tai Chang Hui Wen Cheng Nye Jan Cheng Wan-Ching Ho Chang Min Chung 《Circulation journal》2006,70(12):1611-1616
BACKGROUND: This study investigated the utility of the alveolar - arterial oxygen pressure difference (AaDO (2)) in predicting the short-term prognosis of acute pulmonary embolism (PE). METHODS AND RESULTS: This study retrospectively enrolled 114 consecutive patients with acute PE, diagnosed by either spiral computed tomography or high probability ventilation - perfusion lung scans. During the first 24 h of admission, all patients had initial artery blood gas collected under room air. Patient exclusion criteria were chronic lung disease, septic emboli, and moderate and low probability lung scans. Patients were assigned to 2 groups based on either 30-day death or a 30-day composite event. Receiver operating characteristic analyses was used to determine the AaDO(2) cut-off value for predicting primary and composite endpoints. Statistical analysis demonstrated significant differences in AaDO(2) between the 30-day composite endpoint group and the 30-day composite event-free survival group (p=0.012). The AaDO(2) had a strong trend between the 30-day death group and the survival group (p=0.062). The best cut-off value for AaDO(2) was 53 mmHg and using this, the positive predictive value for 30-day death was 25% and the negative predictive value was 92%. For the 30-day composite endpoint, the positive predictive value for AaDO(2) was 35%, and the negative predictive value was 84%. In this study, thrombocytopenia was also an indicator of poor prognosis for patients with acute PE. CONCLUSION: The AaDO(2) measurement is a highly useful and simple measurement for predicting short-term prognosis in patients with acute PE. It has high negative predictive value and moderate positive predictive value for 30-day death and 30-day composite event. Aggressive thrombolytic treatment strategies should be considered for patients with an initial poor prognostic parameter (ie, AaDO(2) >or=53 mmHg). 相似文献
34.
Prognostic significance of caspase-3 expression in primary resected esophageal squamous cell carcinoma. 总被引:18,自引:0,他引:18
Jiun-Yi Hsia Chih-Yi Chen Jung-Ta Chen Chung-Ping Hsu Sen-Ei Shai Shyh-Sheng Yang Cheng-Yen Chuang Pei-Yen Wang Jen Miaw 《European journal of surgical oncology》2003,29(1):44-48
AIMS: The present study retrospectively examines the expression of caspase-3 in primary resected esophageal squamous cell carcinoma (ESCC) and the correlation between the outcome of patients and the expression of proteins. METHODS: Immunohistochemistry and Western blot analyses were used to analyse the expression of caspase-3 in 40 archival specimens of patients with primary resected ESCC. RESULTS: According to our cut-off point of the staining for caspase-3, 24 (60%) cases were positive and 16 (40%) negative. Caspase-3 expression correlated with a significant favorable prognosis in primary resected ESCC (P=0.02). A multivariate analysis of clinical and biological factors indicated that stage, tumor differentiation, and caspase-3 expression were independent prognostic factors. CONCLUSIONS: Caspase-3 expression might be a good and new prognostic indicator for primary resected ESCC. 相似文献
35.
C H Kao S J Wang W Y Lin C Y Hsu S Q Liao S H Yeh 《Nuclear medicine communications》1992,13(10):764-766
This study, evaluating the effects of hyperthyroidism (HT) in oesophageal motility, depended on an oesophageal radionuclide transit test. A modified standard method was used to calculate: (a) total mean transit time (MTT), (b) residual fraction (RF) and (c) retrograde index (RI) in a supine position. Eighteen untreated patients with HT and 25 normal volunteers (NV) with a similar age distribution were included in this study. The results showed that oesophageal motility in patients with HT was worse than in the normal controls (P < 0.05 by Student's t-test). The correlation of MTT, RF and RI with size and function of thyroid glands in the patients with HT were calculated to explain the effects of HT in oesophageal motility. The results showed that neither the size nor the function of the thyroid glands in HT affected oesophageal motility. 相似文献
36.
Diffuse pulmonary hemorrhage leading to death is a syndrome which may develop in leptospirosis, but its pathophysiology is not well documented. We report an autopsy case of leptospirosis. A healthy 41-year-old man presented with low back myalgia, dry cough and fever for 4 days and a normal chest X-ray on admission. Acute respiratory failure developed hours later. Profuse bloody fluid appeared in the endotracheal tube immediately after intubation. Chest X-ray showed whiteness across all lung fields. He died of persistent shock 16 h after the onset of acute respiratory failure. Autopsy revealed diffuse pulmonary hemorrhage with hyaline-membrane formation, myocarditis, interstitial nephritis and hepatitis. Silver stain of lung and kidney tissue demonstrated leptospires. Immunohistochemical staining showed inducible nitric oxide synthase in alveolar macrophages. Immunofluorescein staining showed immunoglobulin in alveolar septum and alveolar space. This case suggests that hemorrhagic diffuse alveolar damage with persistent shock is related to over-production of nitric oxide and immunoglobulin deposition in fatal leptospirosis. 相似文献
37.
James A. Case Bai Ling Hsu Timothy M. Bateman S. James Cullom 《Journal of nuclear cardiology》2007,14(3):324-333
Background High-quality attenuation maps are critical for attenuation correction of myocardial perfusion single photon emission computed
tomography studies. The filtered backprojection (FBP) approach can introduce errors, especially with low-count transmission
data. We present a new method for attenuation map reconstruction and examine its performance in phantom and patient data.
Methods and Results The Bayesian iterative transmission gradient algorithm incorporates a spatially varying gamma prior function that preferentially
weights estimated attenuation coefficients toward the soft-tissue value while allowing data-driven solutions for lung and
bone regions. The performance with attenuation-corrected technetium 99m sestamibi clinical images was evaluated in phantom
studies and in 50 low-likelihood patients grouped by body mass index (BMI). The algorithm converged in 15 iterations in the
phantom studies. For the clinical studies, soft-tissue estimates had significantly greater uniformity of mediastinal coefficients
(mean SD, 0.005 cm−1 vs 0.011 cm−1; P<.0001). The accuracy and uniformity of the Bayesian iterative transmission gradient algorithm were independent of BMI, whereas
both declined at higher BMI values with FBP. Attenuation-corrected perfusion images showed improvement in myocardial wall
variability (4.8% to 4.1%, P=.02) for all BMI groups with the new method compared with FBP.
Conclusion This new method for attenuation map reconstruction provides rapidly converging and accurate attenuation maps over a wide spectrum
of patient BMI values and significantly improves attenuation-corrected perfusion images. 相似文献
38.
Ming-Shian Tsai Wen-Hsi Lin Wen-Ming Hsu Hong-Shiee Lai Po-Huang Lee Wei-Jao Chen 《Journal of gastrointestinal surgery》2008,12(12):2191-2195
Background/aims Surgical resection of choledochal cysts (CC) has become standard treatment. However, surgery is not universally recommended
in early infancy and/or asymptomatic patients. In order to investigate the optimal timing of CC excision, we analyzed clinicopathological
data and surgical results from different age groups.
Material and methods This retrospective review included 107 patients (77 females, 30 males) who underwent CC resection at the National Taiwan University
Hospital between January 1988 and December 2005. Patient demographic, clinical, and surgical data were collected and analyzed.
Results The patients were divided into three groups according to age at the time of surgery: <1 year old (group I, n = 26), 1−16 years old (group II, n = 48), and >16 years old (group III, n = 33). About two thirds of the patients in group I had jaundice, while abdominal pain related to inflammation was the commonest
symptom in groups II and III. Group I suffered significantly fewer surgical complications and less severe liver fibrosis than
groups II or III.
Conclusion CC surgery in infancy and in asymptomatic patients is safe and may prevent the complications of this condition. The results
support a recommendation for early excision. 相似文献
39.
40.
Intestinal schistosomiasis japonica: CT-pathologic correlation 总被引:1,自引:0,他引:1
Lee RC; Chiang JH; Chou YH; Rubesin SE; Wu HP; Jeng WC; Hsu CC; Tiu CM; Chang T 《Radiology》1994,193(2):539